A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin
A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromo...
Gespeichert in:
| Veröffentlicht in: | Journal of toxicology Jg. 2019; H. 2019; S. 1 - 14 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Cairo, Egypt
Hindawi Publishing Corporation
2019
Hindawi John Wiley & Sons, Inc Wiley |
| Schlagworte: | |
| ISSN: | 1687-8191, 1687-8205 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested. |
|---|---|
| AbstractList | A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested. A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract ( Mangifera indica ) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested. A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract ( ) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested. A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested. |
| Audience | Academic |
| Author | Hirka, Gábor Endres, John R. Béres, Erzsébet Glávits, Róbert Szakonyiné, Ilona Pasics Reddeman, Robin A. Clewell, Amy Vértesi, Adél |
| AuthorAffiliation | 1 AIBMR Life Sciences, Inc., 2800 E. Madison St., Suite 202, Seattle, WA 98373, USA 2 TOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, Hungary |
| AuthorAffiliation_xml | – name: 1 AIBMR Life Sciences, Inc., 2800 E. Madison St., Suite 202, Seattle, WA 98373, USA – name: 2 TOXI-COOP Zrt., Magyar Jakobinusok Tere 4/B, H-1122 Budapest, Hungary |
| Author_xml | – sequence: 1 fullname: Szakonyiné, Ilona Pasics – sequence: 2 fullname: Vértesi, Adél – sequence: 3 fullname: Hirka, Gábor – sequence: 4 fullname: Clewell, Amy – sequence: 5 fullname: Endres, John R. – sequence: 6 fullname: Glávits, Róbert – sequence: 7 fullname: Reddeman, Robin A. – sequence: 8 fullname: Béres, Erzsébet |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31467524$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkk1vEzEQhleoiH7AjTOyhCoVQVqPP9cXpCgKUKmIS67I8nrtraONXXY3pfx7vE3SkgqEfLA1fub1zPg9Lg5iiq4oXgM-B-D8gmBQF0wKioE_K45AlHJSEswPdmdQcFgc9_0SY8Gwki-KQwpMSE7YUfF9ihbpLtjUpiZY06L5rWnXZggpouTRVxObhK6c8Wh-N3TGDuhsjAXvOoNCrHPOOzRLcTAhhtgggU_RDgjxZfHcm7Z3r7b7SbH4NF_Mvkyuvn2-nE2vJlZgNkyU9cAqUlcWKJNQ8drLugbCauwdSEzGqCwZcMxrWlLqbAWVA6iwNALoSXG5ka2TWeqbLqxM90snE_R9IHWNNt0QbOu09FYShQWWTjDOykqVUnkqvaCUE-my1seN1s26WrnaupjbbvdE929iuNZNutVCKEWxygJnW4Eu_Vi7ftCr0FvXtia6tO41ISUFLLkc0bdP0GVadzFPKlOS5QIxLx-pxuQGQvRp_IhRVE8FxipPBnimzv9C5VW7Vf7e6HzI8b2EN382-tDhzhsZ-LABbJf6vnP-AQGsR-vp0Xp6a72Mkye4DcO9kXIhof1X0vtN0nX2kvkZ_vfEtmSXGefNIw2K5InR3-P-7Po |
| CitedBy_id | crossref_primary_10_1016_j_sjbs_2020_11_037 crossref_primary_10_1016_j_brainresbull_2025_111520 crossref_primary_10_1007_s43450_022_00297_z crossref_primary_10_1016_j_biopha_2024_117174 crossref_primary_10_3390_toxics13050409 crossref_primary_10_1007_s11696_022_02654_7 crossref_primary_10_1155_2020_6275625 crossref_primary_10_1016_j_pce_2022_103232 crossref_primary_10_1016_j_jep_2021_114100 crossref_primary_10_1016_j_mrgentox_2020_503251 crossref_primary_10_1002_masy_202200115 crossref_primary_10_3390_antiox10020299 crossref_primary_10_2147_NSA_S525423 crossref_primary_10_1002_prp2_70163 crossref_primary_10_1016_j_jep_2020_112996 crossref_primary_10_1155_2022_9089360 crossref_primary_10_3390_life13071589 crossref_primary_10_3390_biom11010079 crossref_primary_10_17495_easdl_2024_12_34_6_485 crossref_primary_10_3390_nano11010132 crossref_primary_10_7759_cureus_65751 crossref_primary_10_1016_j_fct_2021_111997 crossref_primary_10_1016_j_phrs_2022_106283 crossref_primary_10_1016_j_ejphar_2025_177354 crossref_primary_10_1007_s00210_023_02682_4 crossref_primary_10_1007_s11101_022_09812_5 crossref_primary_10_2903_sp_efsa_2020_EN_1783 crossref_primary_10_1002_masy_202100276 crossref_primary_10_1016_j_eujim_2020_101062 crossref_primary_10_1155_2021_1401945 crossref_primary_10_1016_j_eujim_2019_101011 crossref_primary_10_3390_v17070873 crossref_primary_10_1093_nutrit_nuae214 crossref_primary_10_1155_2022_1304839 crossref_primary_10_1080_10408398_2020_1771678 crossref_primary_10_1111_ijfs_14910 crossref_primary_10_3390_foods9050665 crossref_primary_10_1186_s40816_025_00395_0 |
| Cites_doi | 10.1080/01480540802432551 10.1016/j.jaim.2017.04.006 10.1016/j.fct.2007.05.029 10.1016/j.fct.2006.05.009 10.1016/0378-5173(90)90201-E 10.1177/1091581817751142 10.1007/bf00401402 10.5504/BBEQ.2011.0099 10.1002/1520-6866(2001)21:2<175::AID-TCM6>3.0.CO;2-V 10.1111/j.1753-4887.1997.tb01580.x 10.4103/0973-7847.65325 10.1136/jmg.13.2.103 10.1155/2014/691574 10.1155/2018/8143582 10.1016/j.fct.2012.06.032 10.1016/0027-5107(85)90111-3 |
| ContentType | Journal Article |
| Copyright | Copyright © 2019 Robin A. Reddeman et al. COPYRIGHT 2019 John Wiley & Sons, Inc. Copyright © 2019 Robin A. Reddeman et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2019 Robin A. Reddeman et al. 2019 |
| Copyright_xml | – notice: Copyright © 2019 Robin A. Reddeman et al. – notice: COPYRIGHT 2019 John Wiley & Sons, Inc. – notice: Copyright © 2019 Robin A. Reddeman et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 – notice: Copyright © 2019 Robin A. Reddeman et al. 2019 |
| DBID | ADJCN AHFXO RHU RHW RHX AAYXX CITATION NPM 7ST 7U7 8FE 8FG ABJCF ABUWG AEUYN AFKRA ATCPS AZQEC BENPR BGLVJ BHPHI C1K CCPQU CWDGH DWQXO GNUQQ HCIFZ L6V M7S PATMY PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY SOI 7X8 5PM DOA |
| DOI | 10.1155/2019/4763015 |
| DatabaseName | الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete Hindawi Publishing Complete Hindawi Publishing Subscription Journals Hindawi Publishing Open Access CrossRef PubMed Environment Abstracts Toxicology Abstracts ProQuest SciTech Collection ProQuest Technology Collection ProQuest Materials Science & Engineering ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Agricultural & Environmental Science & Pollution Managment ProQuest Central Essentials ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College Middle East & Africa Database ProQuest Central ProQuest Central Student SciTech Premium Collection ProQuest Engineering Collection Engineering Database Environmental Science Database ProQuest Central Premium ProQuest One Academic ProQuest Publicly Available Content ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Download PDF from ProQuest Environmental Science Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student Technology Collection ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Engineering Collection Middle East & Africa Database Natural Science Collection ProQuest Central Korea Agricultural & Environmental Science Collection ProQuest Central (New) Engineering Collection Engineering Database Toxicology Abstracts ProQuest One Academic Eastern Edition ProQuest Technology Collection ProQuest SciTech Collection Environmental Science Collection ProQuest One Academic UKI Edition Materials Science & Engineering Collection Environmental Science Database ProQuest One Academic Environment Abstracts ProQuest One Academic (New) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database CrossRef PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: RHX name: Hindawi Publishing Open Access url: http://www.hindawi.com/journals/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Public Health |
| EISSN | 1687-8205 |
| Editor | Upham, Brad |
| Editor_xml | – sequence: 1 givenname: Brad surname: Upham fullname: Upham, Brad |
| EndPage | 14 |
| ExternalDocumentID | oai_doaj_org_article_7fc7290607e64548b9879f37f633527e PMC6699309 A600917815 31467524 10_1155_2019_4763015 1192227 |
| Genre | Journal Article |
| GeographicLocations | Hungary France Spain Asia United States--US Germany |
| GeographicLocations_xml | – name: Spain – name: France – name: Hungary – name: Asia – name: Germany – name: United States--US |
| GrantInformation_xml | – fundername: Nektium Pharma SL, Spain |
| GroupedDBID | --- 0R~ 188 24P 2UF 2WC 4.4 53G 5VS 7XC 8FE 8FG 8FH 8R4 8R5 AAFWJ AAMMB ABDBF ABJCF ABUWG ACCMX ACIWK ACPRK ACUHS ADBBV ADJCN ADRAZ AEFGJ AEUYN AFKRA AFPKN AFRAH AGXDD AHFXO AIDQK AIDYY ALMA_UNASSIGNED_HOLDINGS AOIJS ATCPS BAWUL BCNDV BENPR BGLVJ BHPHI BPHCQ CCPQU CWDGH DIK E3Z EBD EBS EJD ESX GROUPED_DOAJ GX1 H13 HCIFZ HYE IAO IEA IHR IL9 INH INR ITC KQ8 L6V M48 M7S O5R O5S OK1 PATMY PGMZT PHGZM PHGZT PIMPY PQGLB PQQKQ PROAC PTHSS PUEGO PYCSY Q2X RHU RNS RPM TR2 TUS UZ5 ~8M 3V. AAJEY M~E RHW RHX AAYXX AFFHD ALUQN CITATION CEFSP CNMHZ NPM 7ST 7U7 AZQEC C1K DWQXO GNUQQ PKEHL PQEST PQUKI PRINS SOI 7X8 5PM |
| ID | FETCH-LOGICAL-c604t-9cf14b2dbc13471b5df7dd124d0fe170234717841505d3833ecb1be11b07a613 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 38 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000481938600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1687-8191 |
| IngestDate | Tue Oct 14 18:54:24 EDT 2025 Tue Nov 04 02:01:12 EST 2025 Wed Oct 01 12:52:01 EDT 2025 Sun Jul 13 04:58:23 EDT 2025 Tue Nov 11 10:55:49 EST 2025 Tue Nov 04 18:19:38 EST 2025 Wed Feb 19 02:34:10 EST 2025 Tue Nov 18 22:32:48 EST 2025 Sat Nov 29 02:56:25 EST 2025 Sun Jun 02 19:16:24 EDT 2024 Thu Sep 25 15:04:05 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2019 |
| Language | English |
| License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c604t-9cf14b2dbc13471b5df7dd124d0fe170234717841505d3833ecb1be11b07a613 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Academic Editor: Brad Upham |
| ORCID | 0000-0002-9044-673X 0000-0002-2582-2778 0000-0002-7333-1383 |
| OpenAccessLink | https://doaj.org/article/7fc7290607e64548b9879f37f633527e |
| PMID | 31467524 |
| PQID | 2274645058 |
| PQPubID | 237777 |
| PageCount | 14 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_7fc7290607e64548b9879f37f633527e pubmedcentral_primary_oai_pubmedcentral_nih_gov_6699309 proquest_miscellaneous_2283107579 proquest_journals_2274645058 gale_infotracmisc_A600917815 gale_infotracacademiconefile_A600917815 pubmed_primary_31467524 crossref_primary_10_1155_2019_4763015 crossref_citationtrail_10_1155_2019_4763015 hindawi_primary_10_1155_2019_4763015 emarefa_primary_1192227 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-00-00 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – year: 2019 text: 2019-00-00 |
| PublicationDecade | 2010 |
| PublicationPlace | Cairo, Egypt |
| PublicationPlace_xml | – name: Cairo, Egypt – name: Egypt – name: New York |
| PublicationTitle | Journal of toxicology |
| PublicationTitleAlternate | J Toxicol |
| PublicationYear | 2019 |
| Publisher | Hindawi Publishing Corporation Hindawi John Wiley & Sons, Inc Wiley |
| Publisher_xml | – name: Hindawi Publishing Corporation – name: Hindawi – name: John Wiley & Sons, Inc – name: Wiley |
| References | 22 (16) 2008 28 (26) 1998 29 (35) 2014 (11) 1998 (19) 2016 (3) 2009; 2 30 31 10 12 13 (34) 2013 (14) 2015; 35 (20) 1998 (23) 1983; 1 (24) 2016 (15) 1997 (25) 1998 1 2 4 5 6 7 8 9 (27) 2008 (17) 1998 |
| References_xml | – year: 1998 ident: 26 – year: 1997 ident: 15 – ident: 8 doi: 10.1080/01480540802432551 – ident: 5 doi: 10.1016/j.jaim.2017.04.006 – year: 1998 ident: 17 – ident: 9 doi: 10.1016/j.fct.2007.05.029 – ident: 7 doi: 10.1016/j.fct.2006.05.009 – ident: 31 doi: 10.1016/0378-5173(90)90201-E – start-page: L142/1 year: 2008 ident: 16 publication-title: Official Journal of the European Union: Brussels – year: 1998 ident: 25 – year: 1998 ident: 11 – ident: 12 doi: 10.1177/1091581817751142 – start-page: 717 volume-title: Chapter 18. Reproductive system and mammary gland year: 2013 ident: 34 – year: 1998 ident: 20 – year: 2016 ident: 24 – ident: 28 doi: 10.1007/bf00401402 – year: 2008 ident: 27 – ident: 2 doi: 10.5504/BBEQ.2011.0099 – volume: 2 start-page: 199 issue: 3 year: 2009 ident: 3 publication-title: Academic Journal of Plant Sciences – ident: 29 doi: 10.1002/1520-6866(2001)21:2<175::AID-TCM6>3.0.CO;2-V – ident: 30 doi: 10.1111/j.1753-4887.1997.tb01580.x – year: 2016 ident: 19 – ident: 1 doi: 10.4103/0973-7847.65325 – volume: 35 start-page: 208 issue: 2 year: 2015 ident: 14 publication-title: International Journal of Toxicology – ident: 22 doi: 10.1136/jmg.13.2.103 – ident: 10 doi: 10.1155/2014/691574 – volume: 1 start-page: 64 year: 1983 ident: 23 publication-title: Clin Cytogen Bull – ident: 13 doi: 10.1155/2018/8143582 – year: 2014 ident: 35 – ident: 6 doi: 10.1016/j.fct.2012.06.032 – ident: 4 doi: 10.1016/0027-5107(85)90111-3 |
| SSID | ssj0064097 |
| Score | 2.3204575 |
| Snippet | A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence... A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract ( Mangifera indica ) containing 60% mangiferin (MLE). No... A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract ( ) containing 60% mangiferin (MLE). No evidence of genotoxicity... |
| SourceID | doaj pubmedcentral proquest gale pubmed crossref hindawi emarefa |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1 |
| SubjectTerms | Biocompatibility Chromosome aberrations Councils Experiments Genotoxicity In vitro methods and tests In vivo methods and tests Laboratories Leaves Mangifera indica Mangoes Mutation Pharmaceuticals Plant extracts Sodium Studies Test methods Toxicity Toxicity testing Toxicology |
| SummonAdditionalLinks | – databaseName: Hindawi Publishing Open Access dbid: RHX link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3di9QwEA96KAgifltdJcIdKlJM2zRpHlfZ4x70ENmHfZGQr94VpJXbPb0_35k2rfZU9K1NpuRjZjIzTeYXQvaVqPOidCbNchtS7g1PlfLwlFeBB2WtZa6_bEIeH1ebjfoYQZK2v2_hg7WD8DxTbzjoAcNk8qtVicL76WgzLrgCIZswrhKgLxh_jOfbL307szw9QH-fhWvg3UwL8vVTDIW_N39yOC-fm_zFEB3eJreiB0mXA8vvkCuhvUtuDr_f6JBVdI98XtJ1d9G4cWmjqwnVm3Y1_WDak46-D6amq4sdJkrRl1iG51wMxW1sZ15RRK4aLpCggh3QkaBp75P14Wr97iiNNymkTjC-S5WrM25zbx1mjma29LX0Hky7Z3XIJNhtKMUdSPCHPMSsRXA2syHLLJMGDP4Dstd2bXhEaDDCY3IuC4XlIjDkJc8z422eSxFCQl6Pk6xdRBnHyy6-6D7aKEuNLNGRJQk5mKi_Dugaf6F7i_yaaBATuy8AOdFRxbSsnUTweiYDwpRVVlVS1YWsBeaVSejaw8jtn22Bfwv9TsgL5L5GncY5NzE1AYaM6Fh6CV4hhLUVdmQxowRddLPq_Sg__xjOYhQuHZeMrYZ-4C4zK6uEPJ-qsQE8BteG7hxp8F44WUoFgxlkcWqoQJtX5jwhcials0mb17TNaQ8oLgR4qUw9_r_ePyE38HX4D7Uge7uz8_CUXHPfds327Fmvmj8AWaYsyQ priority: 102 providerName: Hindawi Publishing – databaseName: Engineering Database dbid: M7S link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3daxQxEA9aFQTx27p6SoQWFVma_Uo2T3LKFR-0CN5DXyTka9sF2W3vrto_35nd7LYrfjz4drcZSCaZTGaSmd8QsiN5lWaF1XGSGh_nTuexlA5-paXPvTTGMNsVmxAHB-XhofwcLtzWIaxy0ImdonatxTvyvRTcJ57DeV2-PTmNsWoUvq6GEhpXyTVESUi70L0vgybmiOWEDheHjYSOyRD4XhTg8ydyL4fNxbAg7qUjqUPu79JzNfzXo6a-cYw-8o_6d5borwGVl06o_Tv_y9tdcjvYpnTeC9M9csU398mt_mKP9vlKD8jXOV2257UdlCZdjHjhtK3oJ90ctfSj1xVdnG8wBYu-wm8YQaMpPpBb_ZoiJlZfmoJytksHgrp5SJb7i-X7D3Go0RBbzvJNLG2V5CZ1xmJOamIKVwnnwGhwrPKJAIsAvuLbJnDnwBvOvDWJ8UlimNBgSjwiW03b-MeEes0dpv0yn5mce4ZSkqeJdgamh3sfkTfDKikb8MuxjMY31fkxRaFwTVVY04jsjtQnPW7HH-je4YKPNIi23X1oV0cqbF4lKisQFp8JjwBopZGlkFUmKo4ZawKGth3E5aIvsJxh3BF5ieKjUFvgnOuQ9AAsI-6WmoO9CQ5ziQOZTShhl9tJ804QwH-wMxskTAVltFYX4hWRF2MzdoABdo1vz5AGK86JQkhgphfmsaMMT9MizSMiJmI-mbRpS1Mfd1DlnIP9y-STvw_rKbmJTPQ3WzOytVmd-Wfkuv2-qder592e_glzXU2k priority: 102 providerName: ProQuest |
| Title | A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin |
| URI | https://search.emarefa.net/detail/BIM-1192227 https://dx.doi.org/10.1155/2019/4763015 https://www.ncbi.nlm.nih.gov/pubmed/31467524 https://www.proquest.com/docview/2274645058 https://www.proquest.com/docview/2283107579 https://pubmed.ncbi.nlm.nih.gov/PMC6699309 https://doaj.org/article/7fc7290607e64548b9879f37f633527e |
| Volume | 2019 |
| WOSCitedRecordID | wos000481938600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: DOA dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: M7S dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database (subscripiton) customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: PATMY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Middle East & Africa Database customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: CWDGH dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/middleeastafrica providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central - New (Subscription) customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVWIB databaseName: Wiley Online Library Open Access customDbUrl: eissn: 1687-8205 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0064097 issn: 1687-8191 databaseCode: 24P dateStart: 20090101 isFulltext: true titleUrlDefault: https://authorservices.wiley.com/open-science/open-access/browse-journals.html providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3di9QwEA96Kggifltdlwh3qBzl0q-kedyTPU7wluXch_VBSr7qFaSVuz29P9-Zpq1bUe7FtzYZyMdMkplk5jeE7EpexklmVBjF2oWpVWkopYWvOHepk1prZtpkE2KxyNdrudxK9YU-YR4e2E_cgSiNQEhyJhyCT-UajGRZJqLkGC0kHO6-oPX0xpTfgzmiOKGpxWEJoUnSu7xnGVj7kTxIYVkxTIW7dRi1mP1tYK6CfzXs0XfO0Dr-Wf1NB_3TlXLrbDp6QO53SiWd-cE8JDdc_Yjc8zdy1AcaPSZfZnTVXFWm3-3ofAD6pk1JT1T9taEfnSrp_GqDsVP0LZah64ui-LJt1DuKYFY-pwTlbI_2BFX9hKyO5qv3x2GXXCE0nKWbUJoySnVstcFg0khnthTWwmlvWekiAUc5lOKjJKhIFszYxBkdaRdFmgkFOsBTslM3tXtOqFPcYrwuc4lOuWPI3jSOlNVxLLhzAdnvJ7kwHfA45r_4VrQGSJYVyJKiY0lA9gbq7x5w4x90h8ivgQZhstsCEJ6iE57iOuEJyLOO27_bApUX-h2QN8j9Apc5zrnqohVgyAiYVcxAUQRLN8eOTEaUsDzNqHq3k59rhjPphavodpGLAvqBD88sywPyeqjGBtAzrnbNJdJgqjiRCQmD8bI4NJTgMZjFaUDESEpHkzauqauzFmOcc1BcmXzxP2b5JbmLQ_UXVxOyszm_dK_IbfNjU12cT8lNsc6n5NbhfLE8nbbLeIoeuJ-gbPnhZPkZ_k6P178Auj9ERA |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3JbtNAdFQKCCTEvgQCDFKjgpAV2xnPZA4IBUjVqmmERA69oNFsbi0huyQpLR_FP_KetzaI5dQDN3vmybP4rTNvIWRD8jQeJFYHUWx8wJxmgZQOnuKhZ14aY0JbFpsQ0-lwf19-XCM_mlgYdKtseGLJqF1h8Yy8H4P5xBnI6-Hbo68BVo3C29WmhEaFFrv--wmYbIs3Ox_g__bieGs8e78d1FUFAstDtgykTSNmYmcsRlFGJnGpcA7EnAtTHwmQYdCKt3EwlgP7beCtiYyPIhMKDcIPPnuJXGbI_EtPwU8N4-eYOgrtOw50i3ZQ42efJH0Qs7LPgJZDrL97TgKWhQLKaGAN77oVDFcP0SQ_yX6n-P7qv3lOIG7d-s-28ja5WWvedFSRyh2y5vO75EZ1bEmraKx75POIzorTzDYigY7bbOi0SOmezg8KOvE6pePTJQaY0ZfYhv5BmuL1v9WvKGb8qgpvUB72aAOQ5ffJ7CIW-ICs50XuHxHqNXcY1Bz6gWHch0gDLI60M_A3uPcd8rpBCmXr7OxYJOSLKq20JFGIQqpGoQ7ptdBHVVaSP8C9Q_xqYTCXeNlQzA9UzZqUSK3ApP-h8JjebWjkUMh0IFKO8XgCpvawxs6zscAugHl3yCZiq0JeiHuu65AOWDJmFVMj0KYl7A9OpLsCCTzMrnRv1Pj-j-V0G4RWNatdqDNs7pAXbTcOgO6DuS-OEQbr6YlESFhMRTvtQAPUFZKYdYhYoaqVTVvtybPDMhE756Ddh_Lx36f1nFzbnu1N1GRnuvuEXMcFVWd4XbK-nB_7p-SK_bbMFvNnJTuhRF0wzf0EwquoBw |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3bbtMw1BobICTE_VIoYKRVA6GoSZrY9QNCHWvFtFFVqA97QZZv2SqhZLQdG5_G33FO4mQr4vK0B94a-6j2cc7VORdCNgXL4l5qVBDF2gWJVUkghIVfcd8lTmitQ1M2m-Djcf_gQEzWyI86FwbDKmuZWApqWxi8I-_G4D6xBPR1v5v5sIjJzujd8dcAO0jhl9a6nUZFInvu-ym4b4u3uzvwrjtxPBpO338IfIeBwLAwWQbCZFGiY6sNZlRGOrUZtxZUng0zF3HQZzCKX-ZgXQu-XM8ZHWkXRTrkChQh_O0VssHBxgDm2tgejiefajXAsJAUensMuBi9ojrqPk27oHRFNwHODrEb7wV9WLYNKHODFTyrRk1cO0IH_XT2OzP412jOC-pxdPs_Ptg75Ja3yemgYqK7ZM3l98jN6kKTVnla98nnAZ0WZzNTKws6bOqk0yKjH1V-WNB9pzI6PFti6hl9hWMYOaQoBgYY9ZpiLbCqJQdlYYfWALP8AZleBoIPyXpe5O4xoU4xi-nOoevphLkQuSOJI2U1vBnmXIu8qQlEGl-3HduHfJGl_5amEslJenJqkU4DfVzVK_kD3DbSWgODVcbLgWJ-KL3QkjwzHNsBhNxh4be-Fn0ush7PGGbqcdjaI0-p52uBxwD7bpEtpFyJUhLPXPlkD0AZ643JAdjZAs4HN9JegQTpZlamNz3t_wOddk3c0gvhhTyn7BZ52UzjAhhYmLviBGGw0x5PuQBkKj5qFuqhFZHGSYvwFQ5bObTVmXx2VJZoZwzs_lA8-fu2XpDrwGpyf3e895TcQHyqy702WV_OT9wzctV8W84W8-detlAiL5npfgKRzbIY |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+Toxicological+Evaluation+of+Mango+Leaf+Extract+%28+Mangifera+indica+%29+Containing+60%25+Mangiferin&rft.jtitle=Journal+of+toxicology&rft.au=Reddeman%2C+Robin+A&rft.au=Gl%C3%A1vits%2C+R%C3%B3bert&rft.au=Endres%2C+John+R&rft.au=Clewell%2C+Amy+E&rft.date=2019&rft.issn=1687-8191&rft.volume=2019&rft.spage=4763015&rft_id=info:doi/10.1155%2F2019%2F4763015&rft_id=info%3Apmid%2F31467524&rft.externalDocID=31467524 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1687-8191&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1687-8191&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1687-8191&client=summon |