Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI

In the past decade, it has become possible to use the nuclear (proton, 1 H) signal of the hydrogen atoms in water for noninvasive assessment of functional and physiological parameters with magnetic resonance imaging (MRI). Here we show that it is possible to produce pH-sensitive MRI contrast by expl...

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Bibliographic Details
Published in:	Nature medicine Vol. 9; no. 8; pp. 1085 - 1090
Main Authors:	Zhou, Jinyuan, Payen, Jean-Francois, Wilson, David A, Traystman, Richard J, van Zijl, Peter C M
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.08.2003 Nature Publishing Group
Subjects:	Animals Biomedical and Life Sciences Biomedicine Brain - anatomy & histology Cancer Research Hydrogen Hydrogen-Ion Concentration Infectious Diseases Ischemia - metabolism Magnetic Resonance Imaging - methods Metabolic Diseases Molecular Medicine Neurosciences Peptides Peptides - chemistry Physiology Proteins - chemistry Protons Rats Rats, Sprague-Dawley Spectroscopy technical-report Water - chemistry
ISSN:	1078-8956, 1546-170X
Online Access:	Get full text
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