Bevacizumab and paclitaxel–carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial

Platinum-based chemotherapy doublets are a standard of care for women with ovarian cancer recurring 6 months after completion of initial therapy. In this study, we aimed to explore the roles of secondary surgical cytoreduction and bevacizumab in this population, and report the results of the bevaciz...

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Bibliographic Details
Published in:	The lancet oncology Vol. 18; no. 6; pp. 779 - 791
Main Authors:	Coleman, Robert L, Brady, Mark F, Herzog, Thomas J, Sabbatini, Paul, Armstrong, Deborah K, Walker, Joan L, Kim, Byoung-Gie, Fujiwara, Keiichi, Tewari, Krishnansu S, O'Malley, David M, Davidson, Susan A, Rubin, Stephen C, DiSilvestro, Paul, Basen-Engquist, Karen, Huang, Helen, Chan, John K, Spirtos, Nick M, Ashfaq, Raheela, Mannel, Robert S
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2017 Elsevier Limited
Subjects:	Adult Aged Aged, 80 and over Angiogenesis Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Bevacizumab - administration & dosage Bevacizumab - adverse effects Cancer therapies Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Carcinoma, Ovarian Epithelial Chemotherapy Clinical trials Cytoreduction Surgical Procedures Disease-Free Survival Fallopian tube Fallopian Tube Neoplasms - therapy Fatigue Female Genital cancers Gynecological cancer Hematology, Oncology and Palliative Medicine Humans Immunotherapy Malignancy Middle Aged Monoclonal antibodies Motivation Myelodysplastic syndrome Neoplasm Recurrence, Local - therapy Neoplasms, Glandular and Epithelial - therapy Neutropenia Oncology Ovarian cancer Ovarian Neoplasms - therapy Paclitaxel Paclitaxel - administration & dosage Paclitaxel - adverse effects Patients Peritoneal Neoplasms - therapy Peritoneum Platinum Proteinuria Sensitivity analysis Studies Surgery Survival Survival Rate Targeted cancer therapy Toxicity Young Adult
ISSN:	1470-2045, 1474-5488, 1474-5488
Online Access:	Get full text
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