Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment

High-dose isoniazid is recommended to treat multidrug-resistant tuberculosis (MDR TB). Among 958 MDR TB isolates identified in France during 2008-2022, 93.1% exhibited high-level isoniazid resistance, and molecular testing showed limited diagnostic accuracy in predicting resistance. Clinicians shoul...

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Bibliographic Details
Published in:	Emerging infectious diseases Vol. 31; no. 3; pp. 633 - 636
Main Authors:	Gerussi, Valentina, Petersen, Tania, Bonnet, Isabelle, Aubry, Alexandra, Bachir, Marwa, Gyde, Esther, Morel, Florence, Poignon, Corentin, Rached, Brigitte, Pourcher, Valérie, Rioux, Christophe, Vallois, Dorothée, Veziris, Nicolas, Robert, Jérôme, Guglielmetti, Lorenzo
Format:	Journal Article
Language:	English
Published:	United States U.S. National Center for Infectious Diseases 01.03.2025 Centers for Disease Control and Prevention
Subjects:	Accuracy Adult Antitubercular Agents - administration & dosage Antitubercular Agents - therapeutic use bacteria Clinical trials Dosage and administration Drug dosages Drug resistance Drug Resistance, Multiple, Bacterial Drug therapy Evaluation of High-Dose Isoniazid in Multidrug-Resistant Tuberculosis Treatment Female France - epidemiology Humans Infectious diseases inhA Isoniazid Isoniazid - administration & dosage Isoniazid - pharmacology Isoniazid - therapeutic use Male MDR TB Microbial Sensitivity Tests Middle Aged Multidrug resistant organisms Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Patient outcomes Research Letter respiratory infections Toxicity Tuberculosis tuberculosis and other mycobacteria Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology France Italy Paris France SCR isoniazid bacteria drug susceptibility testing respiratory infections inhA phenotypic mutation genotypic antimicrobial resistance hepatotoxicity tuberculosis and other mycobacteria MDR TB katG
ISSN:	1080-6040, 1080-6059, 1080-6059
Online Access:	Get full text
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