Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Muscarinic Designer Receptors Exclusively Activated by Designer Drugs (DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation in genetically specified cell-types in vivo . Here we compare the pharmacokinetics, off-target effects and efficacy of CNO, clozapine (CLZ) and...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 4522
Main Authors:	Jendryka, Martin, Palchaudhuri, Monika, Ursu, Daniel, van der Veen, Bastiaan, Liss, Birgit, Kätzel, Dennis, Nissen, Wiebke, Pekcec, Anton
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.03.2019 Nature Publishing Group
Subjects:	14/19 631/378/2649/2150 64/60 692/4017 82/80 96/106 Acetylcholine receptors (muscarinic) Animals Bioavailability Cell activation Cells, Cultured Cerebrospinal fluid Clozapine Clozapine - analogs & derivatives Clozapine - analysis Clozapine - metabolism Clozapine - pharmacokinetics Drug dosages Half-Life Humanities and Social Sciences Ligands Male Metabolites Mice Mice, Inbred C57BL multidisciplinary Neurons - cytology Neurons - metabolism Pharmacodynamics Pharmacokinetics Piperazines - analysis Piperazines - metabolism Piperazines - pharmacokinetics Plasma Proteins Rats Rats, Sprague-Dawley Science Science (multidisciplinary)
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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