Exosome–transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression

Background Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communication, the role of exosomal lncRNA PTENP1 in bladder cancer (BC) remains unclear. Me...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Molecular cancer Ročník 17; číslo 1; s. 143 - 13
Hlavní autoři: Zheng, Rui, Du, Mulong, Wang, Xiaowei, Xu, Weidong, Liang, Jiayuan, Wang, Wenying, Lv, Qiang, Qin, Chao, Chu, Haiyan, Wang, Meilin, Yuan, Lin, Qian, Jing, Zhang, Zhengdong
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 03.10.2018
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Animal research
Apoptosis
Biomarker
Biomarkers
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Cancer
Cancer patients
Cancer Research
Carcinogenesis
Care and treatment
Cell growth
Cell interactions
Communication
Development and progression
Exosomes
Gene expression
Genetic aspects
Health aspects
Medical prognosis
miRNA
Non-coding RNA
Oncology
Phenotypes
Plasma
Progression
Proteins
PTEN protein
PTENP1
Stem cells
Tumors
United States
China
United States > US
Progression
Biomarker
Exosomes
Bladder cancer
PTENP1
ISSN:1476-4598, 1476-4598
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Background Extracellular communication within the tumor microenvironment plays a critical role in tumor progression. Although exosomes can package into long non-coding RNAs (lncRNAs) to mediate extracellular communication, the role of exosomal lncRNA PTENP1 in bladder cancer (BC) remains unclear. Method We detected PTENP1 expression between patients with BC and healthy controls; the expression occurred in tissues and exosomes from plasma. We assessed the diagnostic accuracy by the receiver operating characteristic curve (ROC) and the area under curve (AUC). Cell phenotypes and animal experiments were performed to determine the effect of exosomal PTENP1 . Results PTENP1 was significantly reduced in BC tissues and in exosomes from plasma of patients with BC ( P  < 0.05). We found that PTENP1 was mainly wrapped by exosomes. Exosomal PTENP1 could distinguish patients with BC from healthy controls (AUC = 0.743; 95% confidence interval (CI) = 0.645–0.840). Normal cells secreted exosomal PTENP1 and transmitted it to BC cells, thus inhibiting the biological malignant behavior of BC cells by increasing cell apoptosis and reducing the ability to invade and migrate ( P  < 0.05). Exosomal PTENP1 could suppress tumor growth in vivo. Furthermore, exosomal PTENP1 mediated the expression of PTEN by competitively binding to microRNA-17. Conclusion Exosomal PTENP1 is a promising novel biomarker that can be used for the clinical detection of BC. Exosomes derived from normal cells transfer PTENP1 to BC cells, which reduce the progression of BC both in vitro and in vivo and suggest that exosomal PTENP1 participates in normal-cell-to-bladder-cell communication during the carcinogenesis of BC.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-018-0880-3