RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

Background Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived exosomes have been demonstrated to prevent memory deficits in the animal model of Alzheimer’s disease (AD). However, the intravenously...

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Bibliographic Details
Published in:	Immunity & ageing Vol. 16; no. 1; pp. 10 - 12
Main Authors:	Cui, Guo-hong, Guo, Hai-dong, Li, Han, Zhai, Yu, Gong, Zhang-bin, Wu, Jing, Liu, Jian-sheng, Dong, You-rong, Hou, Shuang-xing, Liu, Jian-ren
Format:	Journal Article
Language:	English
Published:	London BioMed Central 13.05.2019 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Advertising executives Aging Alzheimer's disease Amyloid precursor protein Animal cognition Animal models Antibodies Astrocytes Biomedical and Life Sciences Biomedical materials Biomedicine Bone marrow Brain Central nervous system Chemokines Clinical Nutrition Cognitive ability Cytokines Dementia Diagnosis Exosomes Genetic engineering Geriatrics/Gerontology Health care reform Hippocampus Immunology Inflammation Inflammatory cytokine Interleukin 10 Interleukin 13 Interleukin 4 Interleukin 6 Ischemia Laboratory animals Memory Mesenchymal stem cells Mesenchyme Messenger RNA MicroRNA mRNA Novels Peptides Presenilin 1 Proteins Public Health Quantum dots Rabies Risk factors RNA Rodents Stem cell transplantation Stem cells Target marketing Targeting Transgenic animals Transgenic mice Tumor necrosis factor-α United States > US Alzheimer’s disease Targeting Inflammatory cytokine Exosomes Mesenchymal stem cells
ISSN:	1742-4933, 1742-4933
Online Access:	Get full text
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