The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient depletion, functional RNAi screening and inhibitor treatment. We found that ccRCC cells are highly sensitive to the dep...

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Bibliographic Details
Published in:	Oncogene Vol. 37; no. 40; pp. 5435 - 5450
Main Authors:	Miess, Heike, Dankworth, Beatrice, Gouw, Arvin M., Rosenfeldt, Mathias, Schmitz, Werner, Jiang, Ming, Saunders, Becky, Howell, Michael, Downward, Julian, Felsher, Dean W., Peck, Barrie, Schulze, Almut
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.10.2018 Nature Publishing Group
Subjects:	13/106 13/51 38/77 38/89 631/337/505 631/67/589/1588/1351 64/60 82/58 82/80 Amino acids Apoptosis Basic Helix-Loop-Helix Transcription Factors - metabolism Cancer Cancer cells Carcinoma Carcinoma, Renal Cell - pathology Care and treatment Cell Biology Cell Death Cell Line, Tumor Cell Proliferation Clear cell-type renal cell carcinoma Cysteine Cystine Development and progression Enzyme regulation Enzymes Epithelial cells Fatty acids Ferroptosis Gene silencing Genes Genetic aspects Glutamine Glutathione Glutathione - metabolism Glutathione Peroxidase - metabolism Health aspects Human Genetics Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Internal Medicine Kidney cancer Kidney Neoplasms - pathology Lipid Metabolism Lipid Peroxidation Lipids Medical schools Medicine Medicine & Public Health Metabolism Mitochondria Myc protein Oncology Oxidation Oxidation-Reduction Oxidation-reduction reactions Oxidative metabolism Phosphorylation Renal cell carcinoma RNA interference RNA-mediated interference Tumors VHL protein
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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