H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer

Background H. pylori CagL-Y58/E59 increase gastric cancer risk by stronger binding with integrin to faciliate type IV secretory system (T4SS). H. pylori can secrete high temperature requirement A (HtrA) to mediate E-Cadherin cleavage for gastric epithelial junction disruption, so H. pylori CagL can...

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Vydáno v:	Journal of biomedical science Ročník 26; číslo 1; s. 4 - 8
Hlavní autoři:	Yeh, Yi-Chun, Kuo, Hsin-Yu, Chang, Wei-Lun, Yang, Hsiao-Bai, Lu, Cheng-Chan, Cheng, Hsiu-Chi, Wu, Ming-Shiang, Sheu, Bor-Shyang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 05.01.2019 BioMed Central Ltd Springer Nature B.V BMC
Témata:	Amino acid sequence Amino acid sequencing Amino acids Binding sites Biomedical and Life Sciences Biomedicine CagL Cancer Care and treatment Clinical outcomes Complications and side effects Development and progression Disruption Dyspepsia E-cadherin Endoscopy Epithelium Gastric cancer Gastroenterology Gene sequencing Genetic polymorphisms H. pylori Health risks Helicobacter infections Helicobacter pylori High temperature Histology HtrA Infections Kinases Leucine Mutation Peptic ulcers Polymerase chain reaction Proteins Risk Risk factors Stomach cancer Temperature requirements Type IV secretory system Ulcers Upgrading Taiwan HtrA Type IV secretory system CagL Gastric cancer H. pylori
ISSN:	1423-0127, 1021-7770, 1423-0127
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