The H19 Long non-coding RNA in cancer initiation, progression and metastasis – a proposed unifying theory

The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo, down-regulated at birth and then reappears in tumors. Its role in tumor initiation and progression has long been a subject of controversy, although accumulating data suggest that H19 is one of the major genes in can...

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Bibliographic Details
Published in:	Molecular cancer Vol. 14; no. 1; p. 184
Main Authors:	Raveh, Eli, Matouk, Imad J., Gilon, Michal, Hochberg, Abraham
Format:	Journal Article
Language:	English
Published:	London BioMed Central 04.11.2015 BioMed Central Ltd Springer Nature B.V
Subjects:	Analysis Animals Biomedical and Life Sciences Biomedicine Cancer Research Carcinogenesis Care and treatment Cell cycle Chromosomes Disease Progression Epithelial-Mesenchymal Transition - genetics Epithelial-Mesenchymal Transition - physiology Gastric cancer Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Genetic aspects Genomic Instability - genetics Humans Hypoxia Metabolism Metastasis Mutation Oncology Proteins Review Risk factors RNA, Long Noncoding - genetics RNA, Long Noncoding - physiology Stem cell research Tumorigenesis H19 miR-675 let-7 miR-200 Tumorigenesis Proliferation Differentiation EMT MET Genomic instability
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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