A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis
Background Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dy...
Uloženo v:
| Vydáno v: | Systematic reviews Ročník 7; číslo 1; s. 241 - 12 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
BioMed Central
20.12.2018
Springer Nature B.V BMC |
| Témata: | |
| ISSN: | 2046-4053, 2046-4053 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Background
Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation.
Methods
EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported.
Results
Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54–72%) and good (94–100%) using the Downs and Black checklist.
Conclusions
There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. |
|---|---|
| AbstractList | Background Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation. Methods EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported. Results Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54–72%) and good (94–100%) using the Downs and Black checklist. Conclusions There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation.BACKGROUNDChronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation.EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported.METHODSEMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported.Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54-72%) and good (94-100%) using the Downs and Black checklist.RESULTSSeven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54-72%) and good (94-100%) using the Downs and Black checklist.There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME.CONCLUSIONSThere is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. Abstract Background Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation. Methods EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported. Results Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54–72%) and good (94–100%) using the Downs and Black checklist. Conclusions There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation. EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported. Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54-72%) and good (94-100%) using the Downs and Black checklist. There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. Background Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous constellation of symptoms. The aetiology of this condition remains unknown; however, it has been previously suggested that enteric dysbiosis is implicated in the pathogenesis of CFS/ME. This review examines the evidence currently available for the presence of abnormal microbial ecology in CFS/ME in comparison to healthy controls, with one exception being probiotic-supplemented CFS/ME patients, and whether the composition of the microbiome plays a role in symptom causation. Methods EMBASE, Medline (via EBSCOhost), Pubmed and Scopus were systematically searched from 1994 to March 2018. All studies that investigated the gut microbiome composition of CFS/ME patients were initially included prior to the application of specific exclusion criteria. The association between these findings and patient-centred outcomes (fatigue, quality of life, gastrointestinal symptoms, psychological wellbeing) are also reported. Results Seven studies that met the inclusion criteria were included in the review. The microbiome composition of CFS/ME patients was compared with healthy controls, with the exception of one study that compared to probiotic-supplemented CFS/ME patients. Differences were reported in each study; however, only three were considered statistically significant, and the findings across all studies were inconsistent. The quality of the studies included in this review scored between poor (< 54%), fair (54–72%) and good (94–100%) using the Downs and Black checklist. Conclusions There is currently insufficient evidence for enteric dysbiosis playing a significant role in the pathomechanism of CFS/ME. Recommendations for future research in this field include the use of consistent criteria for the diagnosis of CFS/ME, reduction of confounding variables by controlling factors that influence microbiome composition prior to sample collection and including more severe cases of CFS/ME. |
| ArticleNumber | 241 |
| Author | Eaton, N. Cabanas, H. Corbitt, M. Du Preez, S. Staines, D. Marshall-Gradisnik, S. |
| Author_xml | – sequence: 1 givenname: S. orcidid: 0000-0002-9693-8858 surname: Du Preez fullname: Du Preez, S. email: ncned@griffith.edu.au organization: National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, School of Medical Science, Griffith University – sequence: 2 givenname: M. surname: Corbitt fullname: Corbitt, M. organization: National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University – sequence: 3 givenname: H. surname: Cabanas fullname: Cabanas, H. organization: National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, School of Medical Science, Griffith University – sequence: 4 givenname: N. surname: Eaton fullname: Eaton, N. organization: National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, School of Medical Science, Griffith University – sequence: 5 givenname: D. surname: Staines fullname: Staines, D. organization: National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, School of Medical Science, Griffith University – sequence: 6 givenname: S. surname: Marshall-Gradisnik fullname: Marshall-Gradisnik, S. organization: National Centre for Neuroimmunology and Emerging Diseases, Menzies Health Institute, Griffith University, School of Medical Science, Griffith University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30572962$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kk1v1DAQhiNUREvpD-CCInHhEmrHH7EvSFXFR6VKXOCK5TiTrFeJvdhJq_33zJIW2krgi62Z9300M56XxVGIAYriNSXvKVXyPFMmOasIVRXRRFfkWXFSEy4rTgQ7evA-Ls5y3hI8UhBK5IvimBHR1FrWJ8WPizLv8wyTnb0rE9x4uC1jX0KYIWGk2-fWx-xz6UPpNikGDPYoHhZAZ-hSnOB82ttxwAQEB7uNHeO0h9HPPr8qnvd2zHB2d58W3z99_Hb5pbr--vnq8uK6cpKwubJdy3qqreg1c9DKnsmOKQ1aaK25lZpqKRgnoLiCRrGm62VDa8FZ3TvCO3ZaXK3cLtqt2SU_2bQ30XrzOxDTYGzCDkcwvOlAN61urWgQLVqNBEeVcrwDLjSyPqys3dJO0DkcRbLjI-jjTPAbM8QbIxmpa10j4N0dIMWfC-TZTD47GEcbIC7Z1BTbUkKog_TtE-k2LingqFAllVDYpEDVm4cV_Snl_htR0KwCl2LOCXrj_IyfFA8F-tFQYg47Y9adMbgz5rAzhqCTPnHew__nqVdPRm0YIP0t-t-mX6hK05M |
| CitedBy_id | crossref_primary_10_1186_s12967_020_02665_6 crossref_primary_10_3390_jcm10204786 crossref_primary_10_3389_fimmu_2021_628741 crossref_primary_10_1111_apha_14122 crossref_primary_10_1097_CM9_0000000000002846 crossref_primary_10_1136_bmjopen_2022_061419 crossref_primary_10_3389_fimmu_2024_1352744 crossref_primary_10_1016_j_pnpbp_2020_109976 crossref_primary_10_1186_s12967_023_04227_y crossref_primary_10_1016_j_phrs_2021_105465 crossref_primary_10_3389_fmicb_2023_1190894 crossref_primary_10_1186_s12883_019_1433_0 crossref_primary_10_3389_fncel_2021_673217 crossref_primary_10_1038_s41396_021_00998_8 crossref_primary_10_3390_biom11020284 crossref_primary_10_1016_j_msard_2022_103639 crossref_primary_10_1371_journal_pone_0273855 crossref_primary_10_1186_s12967_019_1797_3 crossref_primary_10_3389_fphys_2021_716520 crossref_primary_10_3390_jcm10215077 crossref_primary_10_1186_s12967_025_06527_x crossref_primary_10_1038_s41598_024_53784_9 crossref_primary_10_1016_j_chom_2023_01_004 crossref_primary_10_1016_j_molmed_2024_02_003 crossref_primary_10_1093_oxfimm_iqad003 crossref_primary_10_12688_f1000research_20510_1 crossref_primary_10_1016_j_autneu_2024_103198 crossref_primary_10_1186_s12967_020_02585_5 crossref_primary_10_1038_s41598_020_66833_w |
| Cites_doi | 10.1300/J092v12n01_03 10.1186/s12967-017-1293-6 10.1007/s11306-016-1145-z 10.4049/jimmunol.1203100 10.1016/j.anaerobe.2013.06.002 10.1186/s13099-018-0230-4 10.1128/JCM.36.4.995-998.1998 10.7326/0003-4819-108-3-387 10.1177/1756283X13482996 10.1016/j.clinthera.2016.04.038 10.1038/nature15766 10.1186/1471-2458-11-402 10.1371/journal.pone.0145453 10.1186/s40168-017-0261-y 10.1016/j.jad.2006.08.021 10.7326/0003-4819-121-12-199412150-00009 10.1126/science.1223490 10.2147/CLEP.S96797 10.1111/j.1365-2796.2011.02428.x 10.1176/appi.ajp.160.2.221 10.1053/j.gastro.2009.01.072 10.1016/j.jad.2012.02.023 10.1093/ije/dym018 10.1300/J092v11n01_02 10.1038/nrg3182 10.1016/j.tim.2012.05.003 10.1111/j.1600-0404.2007.00840.x 10.3390/nu4081095 10.1186/s40168-016-0171-4 10.1136/jech.52.6.377 10.7717/peerj.4282 10.1186/1472-6963-11-217 10.3389/fphys.2017.00088 10.1186/1477-7525-12-64 10.1007/s12602-018-9397-8 10.1186/s13073-016-0294-z 10.1128/JCM.42.3.1220-1223.2004 10.1111/jhn.12435 10.1371/journal.pone.0016952 10.1016/j.cell.2014.03.011 10.3129/i08-001 10.1186/1757-4749-1-6 |
| ContentType | Journal Article |
| Copyright | The Author(s). 2018 Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s). 2018 – notice: Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. KB0 M0S M1P NAPCQ PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM DOA |
| DOI | 10.1186/s13643-018-0909-0 |
| DatabaseName | Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & allied health premium. Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Database (Alumni Edition) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7RV name: Nursing & Allied Health Database url: https://search.proquest.com/nahs sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2046-4053 |
| EndPage | 12 |
| ExternalDocumentID | oai_doaj_org_article_47de97b9ba574a65b9c04c188c4de459 PMC6302292 30572962 10_1186_s13643_018_0909_0 |
| Genre | Research Support, Non-U.S. Gov't Systematic Review Journal Article |
| GroupedDBID | 0R~ 53G 5VS 7RV 7X7 88E 8AO 8FI 8FJ AAFWJ AAJSJ AASML ABDBF ABUWG ACGFS ACUHS ADBBV ADRAZ ADUKV AFKRA AFPKN AHBYD AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AOIJS BAWUL BCNDV BENPR BFQNJ BKEYQ BMC BPHCQ BVXVI C6C CCPQU DIK EBLON EBS ECGQY EJD FYUFA GROUPED_DOAJ H13 HMCUK HYE IAO IHR INH ITC KQ8 M1P M48 M~E NAPCQ OK1 PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO RBZ ROL RPM RSV SMD SOJ UKHRP AAYXX AFFHD CITATION ALIPV CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 5PM |
| ID | FETCH-LOGICAL-c603t-adb3f19a5f93ceb6f36d389e959994a691965340e848e7837df67125432fc04d3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 32 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000454166200003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2046-4053 |
| IngestDate | Fri Oct 03 12:51:54 EDT 2025 Tue Nov 04 01:57:53 EST 2025 Thu Oct 02 09:27:48 EDT 2025 Tue Oct 21 12:46:23 EDT 2025 Thu Apr 03 07:10:01 EDT 2025 Sat Nov 29 03:10:44 EST 2025 Tue Nov 18 20:44:38 EST 2025 Sat Sep 06 07:20:31 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Systematic review Dysbiosis Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) Microbiome |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c603t-adb3f19a5f93ceb6f36d389e959994a691965340e848e7837df67125432fc04d3 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0000-0002-9693-8858 |
| OpenAccessLink | https://doaj.org/article/47de97b9ba574a65b9c04c188c4de459 |
| PMID | 30572962 |
| PQID | 2168581255 |
| PQPubID | 2040188 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_47de97b9ba574a65b9c04c188c4de459 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6302292 proquest_miscellaneous_2159985582 proquest_journals_2168581255 pubmed_primary_30572962 crossref_citationtrail_10_1186_s13643_018_0909_0 crossref_primary_10_1186_s13643_018_0909_0 springer_journals_10_1186_s13643_018_0909_0 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-12-20 |
| PublicationDateYYYYMMDD | 2018-12-20 |
| PublicationDate_xml | – month: 12 year: 2018 text: 2018-12-20 day: 20 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Systematic reviews |
| PublicationTitleAbbrev | Syst Rev |
| PublicationTitleAlternate | Syst Rev |
| PublicationYear | 2018 |
| Publisher | BioMed Central Springer Nature B.V BMC |
| Publisher_xml | – name: BioMed Central – name: Springer Nature B.V – name: BMC |
| References | Y Belkaid (909_CR10) 2014; 157 M Frémont (909_CR25) 2013; 22 LV Hooper (909_CR12) 2012; 336 CM Guinane (909_CR15) 2013; 6 M Maes (909_CR19) 2012; 141 BI Brown (909_CR30) 2014; 20 SM Collin (909_CR36) 2011; 11 MC Panelli (909_CR1) 2017; 15 JJ Verweij (909_CR42) 2004; 42 BM Carruthers (909_CR3) 2011; 270 JR Sheedy (909_CR23) 2009; 23 K Brown (909_CR43) 2012; 4 909_CR4 LC Nacul (909_CR44) 2011; 11 AV Rao (909_CR26) 2009; 1 909_CR8 GP Holmes (909_CR29) 1988; 108 U Morgan f (909_CR41) 1998; 36 GA Preidis (909_CR35) 2009; 136 N Kamada (909_CR11) 2013; 190 909_CR38 P Hooper (909_CR21) 2008; 43 909_CR22 M Maes (909_CR31) 2007; 99 S Sanderson (909_CR46) 2007; 36 BM Carruthers (909_CR6) 2003; 11 909_CR24 A Collatz (909_CR39) 2016; 38 N Campagnolo (909_CR32) 2017; 30 K Fukuda (909_CR5) 1994; 121 K Forslund (909_CR34) 2015; 528 Y Momozawa (909_CR40) 2011; 6 SC Johnston (909_CR2) 2014; 12 SH Downs (909_CR20) 1998; 52 M Maes (909_CR18) 2007; 28 VB Wyller (909_CR16) 2007; 115 D Nagy-Szakal (909_CR45) 2017; 5 I Cho (909_CR13) 2012; 13 SC Johnston (909_CR37) 2016; 8 A Langdon (909_CR14) 2016; 8 M Candela (909_CR9) 2012; 20 N Afari (909_CR17) 2003; 160 LA Jason (909_CR7) 2004; 12 909_CR27 J Lawrence (909_CR33) 2016; 297 909_CR28 |
| References_xml | – volume: 12 start-page: 37 year: 2004 ident: 909_CR7 publication-title: Journal of Chronic Fatigue Syndrome doi: 10.1300/J092v12n01_03 – volume: 15 start-page: 192 year: 2017 ident: 909_CR1 publication-title: J Transl Med doi: 10.1186/s12967-017-1293-6 – ident: 909_CR24 doi: 10.1007/s11306-016-1145-z – volume: 190 start-page: 1389 year: 2013 ident: 909_CR11 publication-title: J Immunol doi: 10.4049/jimmunol.1203100 – volume: 22 start-page: 50 year: 2013 ident: 909_CR25 publication-title: Anaerobe doi: 10.1016/j.anaerobe.2013.06.002 – ident: 909_CR8 doi: 10.1186/s13099-018-0230-4 – volume: 28 start-page: 739 year: 2007 ident: 909_CR18 publication-title: Neuroendocrinol Lett – volume: 36 start-page: 995 year: 1998 ident: 909_CR41 publication-title: J Clin Microbiol doi: 10.1128/JCM.36.4.995-998.1998 – volume: 108 start-page: 387 year: 1988 ident: 909_CR29 publication-title: Ann Intern Med doi: 10.7326/0003-4819-108-3-387 – volume: 6 start-page: 295 year: 2013 ident: 909_CR15 publication-title: Therap Adv Gastroenterol doi: 10.1177/1756283X13482996 – volume: 38 start-page: 1263 year: 2016 ident: 909_CR39 publication-title: Clin Ther doi: 10.1016/j.clinthera.2016.04.038 – volume: 528 start-page: 262 year: 2015 ident: 909_CR34 publication-title: Nature doi: 10.1038/nature15766 – volume: 11 start-page: 402 year: 2011 ident: 909_CR44 publication-title: BMC Public Health doi: 10.1186/1471-2458-11-402 – ident: 909_CR22 doi: 10.1371/journal.pone.0145453 – volume: 5 start-page: 44 year: 2017 ident: 909_CR45 publication-title: Microbiome doi: 10.1186/s40168-017-0261-y – volume: 99 start-page: 237 year: 2007 ident: 909_CR31 publication-title: J Affect Disord doi: 10.1016/j.jad.2006.08.021 – volume: 121 start-page: 953 year: 1994 ident: 909_CR5 publication-title: Ann Intern Med doi: 10.7326/0003-4819-121-12-199412150-00009 – volume: 23 start-page: 621 year: 2009 ident: 909_CR23 publication-title: In Vivo – volume: 336 start-page: 1268 year: 2012 ident: 909_CR12 publication-title: Science doi: 10.1126/science.1223490 – volume: 8 start-page: 97 year: 2016 ident: 909_CR37 publication-title: Clin Epidemiol doi: 10.2147/CLEP.S96797 – volume: 270 start-page: 327 year: 2011 ident: 909_CR3 publication-title: J Intern Med doi: 10.1111/j.1365-2796.2011.02428.x – volume: 160 start-page: 221 year: 2003 ident: 909_CR17 publication-title: AJP doi: 10.1176/appi.ajp.160.2.221 – volume: 20 start-page: 29 year: 2014 ident: 909_CR30 publication-title: Altern Ther Health Med – volume: 136 start-page: 2015 year: 2009 ident: 909_CR35 publication-title: Gastroenterology doi: 10.1053/j.gastro.2009.01.072 – volume: 141 start-page: 55 year: 2012 ident: 909_CR19 publication-title: J Affect Disord doi: 10.1016/j.jad.2012.02.023 – volume: 36 start-page: 666 year: 2007 ident: 909_CR46 publication-title: Int J Epidemiol doi: 10.1093/ije/dym018 – volume: 11 start-page: 7 year: 2003 ident: 909_CR6 publication-title: Journal of Chronic Fatigue Syndrome. doi: 10.1300/J092v11n01_02 – volume: 13 start-page: 260 year: 2012 ident: 909_CR13 publication-title: Nat Rev Genet doi: 10.1038/nrg3182 – volume: 20 start-page: 385 year: 2012 ident: 909_CR9 publication-title: Trends Microbiol doi: 10.1016/j.tim.2012.05.003 – volume: 115 start-page: 7 year: 2007 ident: 909_CR16 publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.2007.00840.x – volume: 4 start-page: 1095 year: 2012 ident: 909_CR43 publication-title: Nutrients doi: 10.3390/nu4081095 – ident: 909_CR27 doi: 10.1186/s40168-016-0171-4 – volume: 52 start-page: 377 year: 1998 ident: 909_CR20 publication-title: J Epidemiol Community Health doi: 10.1136/jech.52.6.377 – ident: 909_CR28 doi: 10.7717/peerj.4282 – volume: 297 start-page: 24 year: 2016 ident: 909_CR33 publication-title: Pharmaceutical Journal – volume: 11 start-page: 217 year: 2011 ident: 909_CR36 publication-title: BMC Health Serv Res doi: 10.1186/1472-6963-11-217 – ident: 909_CR38 doi: 10.3389/fphys.2017.00088 – volume: 12 start-page: 64 year: 2014 ident: 909_CR2 publication-title: Health Qual Life Outcomes doi: 10.1186/1477-7525-12-64 – ident: 909_CR4 doi: 10.1007/s12602-018-9397-8 – volume: 8 start-page: 39 year: 2016 ident: 909_CR14 publication-title: Genome Medicine doi: 10.1186/s13073-016-0294-z – volume: 42 start-page: 1220 year: 2004 ident: 909_CR42 publication-title: J Clin Microbiol doi: 10.1128/JCM.42.3.1220-1223.2004 – volume: 30 start-page: 247 year: 2017 ident: 909_CR32 publication-title: J Hum Nutr Diet doi: 10.1111/jhn.12435 – volume: 6 year: 2011 ident: 909_CR40 publication-title: PLoS One doi: 10.1371/journal.pone.0016952 – volume: 157 start-page: 121 year: 2014 ident: 909_CR10 publication-title: Cell doi: 10.1016/j.cell.2014.03.011 – volume: 43 start-page: 180 year: 2008 ident: 909_CR21 publication-title: Can J Ophthalmol doi: 10.3129/i08-001 – volume: 1 start-page: 6 year: 2009 ident: 909_CR26 publication-title: Gut Pathog doi: 10.1186/1757-4749-1-6 |
| SSID | ssj0000650106 |
| Score | 2.3240535 |
| SecondaryResourceType | review_article |
| Snippet | Background
Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a... Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a heterogeneous... Background Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to a... Abstract Background Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is an illness characterised by profound and pervasive fatigue in addition to... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 241 |
| SubjectTerms | Bacteria Biomedicine Chronic fatigue syndrome Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) Chronic illnesses Dietary Supplements Dysbiosis Ecosystems Encephalomyelitis Epidemiology Evidence-based medicine Fatigue Syndrome, Chronic - physiopathology Feces Gastroenterology Gastrointestinal Microbiome Health care Health Sciences Humans Medicine Medicine & Public Health Microbiome Microbiota Nutrition research Patient-centered care Probiotics Quality of life Quality of Life - psychology Statistics for Life Sciences Systematic review |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jb9QwFLagIMSFHRooyEicQNEkcbydUEFUXKg4gDQnrHhrR5omw6RTaf4972UbDUsvXGM7sv12P_t7hLzhXEnmLE-DxxJm0sZUF7xIrc1ZVUXrY3RdsQl5eqrmc_11OHBrh2uVo07sFLVvHJ6Rz4ockdLBHPP3q58pVo3C7OpQQuMmuYVls5HP5VxOZyzofkDIMyQzcyVmbc7ABEP8jDl_TAvsmaMOtf9vruafNyZ_S5t21ujk_v-u4wG5N_ih9LhnnIfkRqgfkTtfhkz7Y_LjmO5Anmn_wIU2kSKEJ6hO6retXTTtoqWLmroeYZdG6Hy2CXSEQZhdbKslqFaK6mN1Xi2bi23A-3btE_L95NO3j5_ToRZD6kTGLtPKWxZzXfGomQtWRCY8-DpBc_Awy0poRCZkZRZUqYKEqNdHIXN8aV9El5WePSUHdVOHQ0I1ll-HX1jBZBm5V8x6DWGNswq0TSYTko0kMW4AKsd6GUvTBSxKmJ6KBqhokIomS8jbaciqR-m4rvMHpPPUEQG2uw_N-swM8mpK6YOWVtuKS1getxpW4XKlXOlDyXVCjkbymkHqW7OjbUJeT80gr5iEqerQbLAP7JgCESkS8qxnqmkmoHsh1hHQIvfYbW-q-y314rzDBBcMnDENI9-NjLmb1j934vn1i3hB7hYoKXkBuvSIHFyuN-Elue2ugE3WrzpR-wUPQDFZ priority: 102 providerName: ProQuest – databaseName: SpringerLink Contemporary dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagIMSFdyFQkJE4gaImcfw6FkTFhQqJh3rCil_tStuk2nSR9t8z4zyqhYIE13gc2eOZ8YzH_oaQV5wryZzlefBYwkzamOuKV7m1JWuaaH2MLhWbkEdH6vhYfxrfcffTbfcpJZksdVJrJfb7ksHuCaEvpuvxRP86ucERbAZD9M_f5oMV9DkgzhkzmFf23NqDElT_Vf7l79ckf8mVpi3o8O5_Df4euTN6nPRgEJH75FpoH5BbH8ec-kPy_YBewjnT4SkL7SJFsE4wktRvervo-kVPFy11A5YujUB8sg50AjzYP9s0SzCiFA3F-Wmz7M42AW_W9Y_I18P3X959yMeqC7kTBbvIG29ZLHXDo2YuWBGZ8ODVBM3Bl6wboRGDkNVFULUKEuJbH4Us8U19FV1Re7ZLdtquDU8I1VhoHX5hBZN15F4x6zUEMM4qsCuFzEgxrYNxIyQ5VsZYmhSaKGEGvhngm0G-mSIjr-cu5wMex9-I3-LizoQIpZ0-dKsTM2qmqaUPWlptGy5hetxqmIUrlXK1DzXXGdmbRMOM-t2bqkTcfpg1z8jLuRk0E9MtTRu6NdIAxxQoQ5WRx4MkzSMBKwtRjYAWuSVjW0PdbmkXpwn9WzBwuzT0fDNJ2uWw_siJp_9E_YzcrlBUywqM6B7ZuVitw3Ny0_0AqVm9SOr2E_sXJus priority: 102 providerName: Springer Nature |
| Title | A systematic review of enteric dysbiosis in chronic fatigue syndrome/myalgic encephalomyelitis |
| URI | https://link.springer.com/article/10.1186/s13643-018-0909-0 https://www.ncbi.nlm.nih.gov/pubmed/30572962 https://www.proquest.com/docview/2168581255 https://www.proquest.com/docview/2159985582 https://pubmed.ncbi.nlm.nih.gov/PMC6302292 https://doaj.org/article/47de97b9ba574a65b9c04c188c4de459 |
| Volume | 7 |
| WOSCitedRecordID | wos000454166200003&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: Open Access: BioMedCentral Open Access Titles customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: RBZ dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: DOA dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: M~E dateStart: 20120101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: 7X7 dateStart: 20140101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: 7RV dateStart: 20140101 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: BENPR dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: PIMPY dateStart: 20140101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLink Contemporary customDbUrl: eissn: 2046-4053 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650106 issn: 2046-4053 databaseCode: RSV dateStart: 20121201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagIMQF8WZLWRmJEyjaJI5fxxa1gkNXqwWq5YIVv-hK26RqupX23zOTZLddnhcukRzbkTMvz2jsbwh5w7mSzFmeBI8lzKSNic55nlibsbKM1sfo2mITcjxWs5me3Cj1hWfCOnjgjnCjQvqgpdW25LIoBbfapYXLlHKFDwVvr-6lUt8IpjobzDHY6dOYmRKjJmOw-ULkjNl-TAhsbUQtXv_vnMxfz0r-lDBt96Gjh-RB70DS_W7hj8itUD0m9477FPkT8m2fXqMz0-5mCq0jRexNsHnUrxo7r5t5Q-cVdR00Lo0w-Psy0DV-wehsVS7AJlLU-_PTclGfrQIelGueki9Hh5_ff0j6IgqJEym7TEpvWcx0yaNmLlgRmfDgpATNwTUEgmqEFGRFGlShgoRw1UchM7win0egtGfPyE5VV-EFoRrrpsMnrGCyiNwrZr2GeMRZBWYilQOSrilqXI8wjoUuFqaNNJQwHRMMMMEgE0w6IG83U847eI2_DT5ANm0GIjJ2-wLkxfTyYv4lLwOyt2ay6dW1MXmGMPzw13xAXm-6QdEwe1JWoV7iGKCYAtnOB-R5JxOblYDRhCBFQI_ckpatpW73VPPTFsxbMPCiNMx8t5ar62X9kRK7_4MSL8n9HNUhy8FU7pGdy4tleEXuuisQposhuS2nJ_icyfaphuTOweF4Mh22mgatycfjyVdoTT-d_ACooCrQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1JbxMxFLZKiigXdkqggJHgAhplZjwe2weEylI1ahPlUKRyqRlvbaR0JmQaUP4Uv5HnWRKFpbceuMaeke18b5v3_D2EXlLKGdGKBtb4FmZMuUDENA6UikiWOWWc01WzCTYc8uNjMdpAP9u7ML6sstWJlaI2hfbfyHtx5JnSwRzTd9Nvge8a5bOrbQuNGhYHdvEDQrbybf8j_L-v4njv09GH_aDpKhDoNCQXQWYUcZHIqBNEW5U6khqw2lZQ8JWSLBWeY48koeUJtwziN-NSFvk747HTYWIIvPca2kwA7GEHbY76g9GX5Vcd7_BAkNWkTyOe9sqIgNGHiN1XGfhExJoBrPoE_M25_bNG87dEbWX_9m7_byd3B91qPG28W4vGXbRh83voxqCpJbiPTnbxisYa11d4cOGwJykF44DNolTjohyXeJxjXXMIYweTT-cWt0QPvfNFNgHjgb2CnJ5lk-J8YX1FYfkAfb6S3T1EnbzI7SOEhW8wD69QKWGJo4YTZQQEblpx0Kch66KwhYDUDRW77wgykVVIxlNZo0YCaqRHjQy76PXykWnNQ3LZ5PceV8uJnkK8-qGYncpGI8mEGSuYEiqjDLZHlYBd6IhznRibUNFFOy2cZKPXSrnCUhe9WA6DRvJppiy3xdzPgRPjoATiLtquQbxcCVgXiOZSGGFr8F5b6vpIPj6rWM9TAu6mgCfftIKwWtY_T-Lx5Zt4jrb2jwaH8rA_PHiCbsZeSqMYLMcO6lzM5vYpuq6_A2RmzxpBx-jrVUvILzrLjdA |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Zb9QwELagoIoX7kJKASPxBIo2iePYfizHCgSsKi71CSu-2pW2yWqzW2n_PTM5tlooSIjXeBzZ45nxjMf-hpDnnEvBrOGxd1jCTJgQq4xnsTEpK8tgXAi2LTYhJhN5fKyO-jqnzXDbfUhJdm8aEKWpWo7mLnQqLotRkzLYSSEMxtQ9nu5fJddyCGTwTtfnL983hyzof0DM02czL-25tR-1sP2X-Zq_X5n8JW_abkfjW_89kdvkZu-J0sNOdO6QK766S3Y_9bn2e-THIb2AeabdExdaB4ognmA8qVs3Zlo304ZOK2o7jF0agPhk5ekAhDA6W5czMK4UDcj8tJzVZ2uPN-6a--Tb-O3X1-_ivhpDbIuELePSGRZSVfKgmPWmCKxw4O14xcHHzMtCITYhyxMvc-kFxL0uFCLFt_ZZsEnu2B7ZqerKPyRUYQF2-IUpmMgDd5IZpyCwsUaCvUlERJJhTbTtocqxYsZMtyGLLHTHNw1808g3nUTkxabLvMPp-BvxK1zoDSFCbLcf6sWJ7jVW58J5JYwyJRcwPW4UzMKmUtrc-ZyriBwMYqJ7vW90liKeP8yaR-TZphk0FtMwZeXrFdIAxyQoSRaRB51UbUYC1heinQJaxJa8bQ11u6Wanrao4AUDd0xBz5eD1F0M64-c2P8n6qdk9-jNWH98P_nwiNzIUGrTDOzsAdlZLlb-Mbluz0GAFk9aLfwJpGYysw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+systematic+review+of+enteric+dysbiosis+in+chronic+fatigue+syndrome%2Fmyalgic+encephalomyelitis&rft.jtitle=Systematic+reviews&rft.au=Du+Preez%2C+S.&rft.au=Corbitt%2C+M.&rft.au=Cabanas%2C+H.&rft.au=Eaton%2C+N.&rft.date=2018-12-20&rft.issn=2046-4053&rft.eissn=2046-4053&rft.volume=7&rft.issue=1&rft_id=info:doi/10.1186%2Fs13643-018-0909-0&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s13643_018_0909_0 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2046-4053&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2046-4053&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2046-4053&client=summon |