Design and rationale of the Procalcitonin Antibiotic Consensus Trial (ProACT), a multicenter randomized trial of procalcitonin antibiotic guidance in lower respiratory tract infection

Background Overuse of antibiotics is a major public health problem, contributing to growing antibiotic resistance. Procalcitonin has been reported to be commonly elevated in bacterial, but not viral infection. Multiple European trials found procalcitonin-guided care reduced antibiotic use in lower r...

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Bibliographic Details
Published in:	BMC emergency medicine Vol. 17; no. 1; pp. 25 - 10
Main Authors:	Huang, David T., Angus, Derek C., Chang, Chung-Chou H., Doi, Yohei, Fine, Michael J., Kellum, John A., Peck-Palmer, Octavia M., Pike, Francis, Weissfeld, Lisa A., Yabes, Jonathan, Yealy, Donald M.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.08.2017 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Anti-bacterial agents Anti-Bacterial Agents - therapeutic use Antibiotic resistance Antibiotics Asthma Bacterial infections Biomarkers Biomarkers - blood Calcitonin - blood Calcitonin Gene-Related Peptide Chronic obstructive pulmonary disease Clinical decision making Clinical medicine Clinical trial Clinical trials Decision Making Drug resistance in microorganisms Drug therapy Emergency medical care Emergency Medicine Emergency Service, Hospital Enrollments Evidence-based medicine Female General emergency medicine Health aspects Hospitalization Humans Infections Male Medicine Medicine & Public Health Methods Methods (MeSH) Outcome and Process Assessment, Health Care Patients Physicians Pneumonia Practice Guidelines as Topic Procalcitonin Protein Precursors - blood Public health Research Design Respiratory tract diseases Respiratory tract infection Respiratory tract infections Respiratory Tract Infections - drug therapy Risk factors Study Protocol Treatment Outcome United States Ventilators Viral infections United States United States > US Respiratory tract infections Biomarkers Clinical trial Methods (MeSH) Anti-bacterial agents Procalcitonin
ISSN:	1471-227X, 1471-227X
Online Access:	Get full text
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