Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial

Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality i...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 19; no. 1; p. 163
Main Authors:	Straat, Marleen, Müller, Marcella CA, Meijers, Joost CM, Arbous, Mendi S, Spoelstra - de Man, Angelique ME, Beurskens, Charlotte JP, Vroom, Margreeth B, Juffermans, Nicole P
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.04.2015 BioMed Central Ltd Springer Nature B.V
Subjects:	Acute respiratory distress syndrome Analysis Blood coagulation factor VIII Blood Component Transfusion - methods Blood products Care and treatment Critical care Critical Care Medicine Critical Illness - therapy Cytokines Emergency Medicine Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Evidence-based medicine Health aspects Health risk assessment Heart surgery Humans Inflammation Inflammation - complications Inflammation - etiology Intensive Intensive care Intensive Care Units - utilization International Normalized Ratio Ligands Medicine & Public Health Mortality Multiple organ dysfunction syndrome Netherlands Patients Permeability Plasma Plasma - drug effects Plasma - metabolism Prospective Studies Risk factors Trauma Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF Von Willebrand factor Netherlands Abciximab Thrombotic Thrombocytopenic Purpura Massive Transfusion Fresh Freeze Plasma
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X
Online Access:	Get full text
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