Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial
Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality i...
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| Vydané v: | Critical care (London, England) Ročník 19; číslo 1; s. 163 |
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| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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London
BioMed Central
15.04.2015
BioMed Central Ltd Springer Nature B.V |
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| ISSN: | 1364-8535, 1466-609X, 1364-8535, 1466-609X, 1366-609X |
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| Abstract | Introduction
Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition.
Methods
A prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired
t
test or the Wilcoxon signed-rank test.
Results
At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-α (from 11.3 to 2.3 pg/ml,
P
= 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml,
P
= 0.01) and a decrease in factor VIII levels (from 246 to 246%,
P
<0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%,
P
<0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%,
P
<0.01).
Conclusions
A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF.
Trial registrations
Trialregister.nl
NTR2262
, registered 26 March 2010 and Clinicaltrials.gov
NCT01143909
, registered 14 June 2010. |
|---|---|
| AbstractList | Introduction
Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition.
Methods
A prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired
t
test or the Wilcoxon signed-rank test.
Results
At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-α (from 11.3 to 2.3 pg/ml,
P
= 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml,
P
= 0.01) and a decrease in factor VIII levels (from 246 to 246%,
P
<0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%,
P
<0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%,
P
<0.01).
Conclusions
A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF.
Trial registrations
Trialregister.nl
NTR2262
, registered 26 March 2010 and Clinicaltrials.gov
NCT01143909
, registered 14 June 2010. Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition. Methods A prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired t test or the Wilcoxon signed-rank test. Results At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-[alpha] (from 11.3 to 2.3 pg/ml, P = 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml, P = 0.01) and a decrease in factor VIII levels (from 246 to 246%, P <0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%, P <0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%, P <0.01). Conclusions A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF. Trial registrations Trialregister.nl NTR2262, registered 26 March 2010 and Clinicaltrials.gov NCT01143909, registered 14 June 2010. Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition. A prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired t test or the Wilcoxon signed-rank test. At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-[alpha] (from 11.3 to 2.3 pg/ml, P = 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml, P = 0.01) and a decrease in factor VIII levels (from 246 to 246%, P <0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%, P <0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%, P <0.01). A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF. Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition. A prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired t test or the Wilcoxon signed-rank test. At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-α (from 11.3 to 2.3 pg/ml, P = 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml, P = 0.01) and a decrease in factor VIII levels (from 246 to 246%, P <0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%, P <0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%, P <0.01). A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF. Trialregister.nl NTR2262, registered 26 March 2010 and Clinicaltrials.gov NCT01143909, registered 14 June 2010. Abbreviations ADAMTS13: a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 APACHE IV score: acute physiology and chronic health evaluation IV score DIC: disseminated intravascular coagulation ELISA: enzyme-linked immunosorbent assay FFP: fresh frozen plasma ICU: intensive care unit IL-1: interleukin 1 IL-10: interleukin 10 IL-1RA: interleukin 1 receptor antagonist IL-1?: interleukin 1 beta IL-8: interleukin 8 INR: international normalized ratio IQR: interquartile range ISTH: International Society on Thrombosis and Haemostasis LMWH: low-molecular-weight heparin MCP-1: monocyte chemotactic protein 1 MIP-1A: macrophage inflammatory proteins 1A sCD40L: soluble CD40 ligand SD: standard deviation SOFA score: sequential organ failure assessment score TNF-?: tumor necrosis factor alpha TRALI: transfusion-related acute lung injury vWF: von Willebrand factor vWF: Risk factors and outcome of transfusion-related acute lung injury in the critically ill: a nested case-control study. Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study. Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition.INTRODUCTIONMuch controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have been well described, including acute lung injury. However, it is also suggested that a higher amount of FFP decreases mortality in trauma patients requiring a massive transfusion. Furthermore, FFP has an endothelial stabilizing effect in experimental models. We investigated the effect of fresh frozen plasma transfusion on systemic inflammation and endothelial condition.A prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired t test or the Wilcoxon signed-rank test.METHODSA prospective predefined substudy of a randomized trial in coagulopathic non-bleeding critically ill patients receiving a prophylactic transfusion of FFP (12 ml/kg) prior to an invasive procedure. Levels of inflammatory cytokines and markers of endothelial condition were measured in paired samples of 33 patients before and after transfusion. The statistical tests used were paired t test or the Wilcoxon signed-rank test.At baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-α (from 11.3 to 2.3 pg/ml, P = 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml, P = 0.01) and a decrease in factor VIII levels (from 246 to 246%, P <0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%, P <0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%, P <0.01).RESULTSAt baseline, systemic cytokine levels were mildly elevated in critically ill patients. FFP transfusion resulted in a decrease of levels of TNF-α (from 11.3 to 2.3 pg/ml, P = 0.01). Other cytokines were not affected. FFP also resulted in a decrease in systemic syndecan-1 levels (from 675 to 565 pg/ml, P = 0.01) and a decrease in factor VIII levels (from 246 to 246%, P <0.01), suggestive of an improved endothelial condition. This was associated with an increase in ADAMTS13 levels (from 24 to 32%, P <0.01) and a concomitant decrease in von Willebrand factor (vWF) levels (from 474 to 423%, P <0.01).A fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF.CONCLUSIONSA fixed dose of FFP transfusion in critically ill patients decreases syndecan-1 and factor VIII levels, suggesting a stabilized endothelial condition, possibly by increasing ADAMTS13, which is capable of cleaving vWF.Trialregister.nl NTR2262, registered 26 March 2010 and Clinicaltrials.gov NCT01143909, registered 14 June 2010.TRIAL REGISTRATIONSTrialregister.nl NTR2262, registered 26 March 2010 and Clinicaltrials.gov NCT01143909, registered 14 June 2010. |
| ArticleNumber | 163 |
| Audience | Academic |
| Author | Spoelstra - de Man, Angelique ME Arbous, Mendi S Beurskens, Charlotte JP Juffermans, Nicole P Straat, Marleen Müller, Marcella CA Meijers, Joost CM Vroom, Margreeth B |
| Author_xml | – sequence: 1 givenname: Marleen surname: Straat fullname: Straat, Marleen email: m.straat@amc.uva.nl organization: Department of Intensive Care Medicine, Academic Medical Center, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center – sequence: 2 givenname: Marcella CA surname: Müller fullname: Müller, Marcella CA organization: Department of Intensive Care Medicine, Academic Medical Center, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center – sequence: 3 givenname: Joost CM surname: Meijers fullname: Meijers, Joost CM organization: Department of Experimental Vascular Medicine, Academic Medical Center – sequence: 4 givenname: Mendi S surname: Arbous fullname: Arbous, Mendi S organization: Department of Intensive Care Medicine, Leiden University Medical Center – sequence: 5 givenname: Angelique ME surname: Spoelstra - de Man fullname: Spoelstra - de Man, Angelique ME organization: Department of Intensive Care Medicine, VU Medical Center – sequence: 6 givenname: Charlotte JP surname: Beurskens fullname: Beurskens, Charlotte JP organization: Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center – sequence: 7 givenname: Margreeth B surname: Vroom fullname: Vroom, Margreeth B organization: Department of Intensive Care Medicine, Academic Medical Center – sequence: 8 givenname: Nicole P surname: Juffermans fullname: Juffermans, Nicole P organization: Department of Intensive Care Medicine, Academic Medical Center, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25880761$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1055/s-0037-1616068 10.1111/j.1365-3083.2009.02278.x 10.1111/j.1537-2995.2011.03403.x 10.1186/1745-6215-12-266 10.1001/archsurg.2010.216 10.1097/SLA.0b013e318185a9ad 10.1016/j.injury.2010.12.015 10.1016/j.jss.2009.04.034 10.1371/journal.pone.0033403 10.1097/01.CCM.0000186745.53059.F0 10.1097/CCM.0b013e31825b8e20 10.1097/CCM.0b013e318168f89d 10.1097/SHK.0b013e31829f91fc 10.1016/j.jss.2010.04.049 10.1182/blood-2011-08-370932 10.1016/j.thromres.2005.12.006 10.1097/TA.0b013e3182a92514 10.1111/j.1537-2995.2010.02816.x 10.1309/AJCPH16YXJEFSHEO 10.1097/CCM.0b013e3181cc4d4b 10.1016/S0140-6736(12)62197-7 10.1111/j.1365-2141.2004.04972.x 10.1378/chest.101.6.1481 10.1182/blood-2009-02-204966 10.1111/trf.12422 10.1111/j.1537-2995.2010.02798.x 10.1213/ANE.0b013e318210385c 10.1378/chest.121.4.1262 10.1111/trf.12231 10.1111/j.1537-2995.2011.03247.x 10.1016/j.jcrc.2013.04.010 10.1182/blood-2006-04-017251 10.1111/trf.12040 10.1111/j.1537-2995.2004.04053.x |
| ContentType | Journal Article |
| Copyright | Straat et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated. COPYRIGHT 2015 BioMed Central Ltd. Copyright BioMed Central 2015 Straat et al.; licensee BioMed Central. 2015 |
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| Keywords | Abciximab Thrombotic Thrombocytopenic Purpura Massive Transfusion Fresh Freeze Plasma |
| Language | English |
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| References | LN Torres (828_CR38) 2013; 75 SR Ostrowski (828_CR25) 2013; 28 A Tinmouth (828_CR2) 2013; 53 K Wataha (828_CR37) 2013; 53 RJ Haywood-Watson (828_CR23) 2011; 6 B Sarani (828_CR12) 2008; 36 AP Vlaar (828_CR14) 2012; 40 SY Khan (828_CR31) 2006; 108 SJ Stanworth (828_CR1) 2011; 51 M Urner (828_CR33) 2012; 7 SI Dara (828_CR4) 2005; 33 PA Letourneau (828_CR15) 2010; 163 LM Brown (828_CR18) 2011; 71 RA Kozar (828_CR39) 2011; 112 J Steppan (828_CR24) 2011; 165 U Nienaber (828_CR21) 2011; 42 LA Chambers (828_CR19) 2011; 136 N Reiter (828_CR5) 2013; 60 C Narick (828_CR10) 2012; 52 JL Johnson (828_CR11) 2010; 145 FB Taylor Jr (828_CR29) 2001; 86 RC Bone (828_CR28) 1992; 101 AF Shorr (828_CR32) 2002; 121 O Gajic (828_CR7) 2004; 44 Z Peng (828_CR26) 2013; 40 B Nohe (828_CR36) 2003; 97 K Hayashida (828_CR22) 2009; 114 SO Schneider (828_CR34) 2009; 70 JL Sperry (828_CR41) 2008; 65 DF O'Shaughnessy (828_CR3) 2004; 126 A Doussau (828_CR20) 2014; 54 AP Vlaar (828_CR6) 2010; 38 G Li (828_CR9) 2011; 51 S Pati (828_CR35) 2011; 69 GA Watson (828_CR8) 2009; 67 MC Muller (828_CR27) 2011; 12 V Kostousov (828_CR30) 2006; 118 JB Holcomb (828_CR17) 2008; 248 AP Vlaar (828_CR16) 2013; 382 SA Arinsburg (828_CR42) 2012; 52 MA Borgman (828_CR40) 2007; 63 P Toy (828_CR13) 2012; 119 20599210 - J Surg Res. 2010 Oct;163(2):317-22 22196464 - Trials. 2011;12:266 20723173 - Transfusion. 2011 Feb;51(2):338-43 15198728 - Br J Haematol. 2004 Jul;126(1):11-28 23301978 - Transfusion. 2013 Jan;53 Suppl 1:80S-90S 19638625 - Blood. 2009 Oct 1;114(14):3033-43 20804532 - Transfusion. 2011 Jan;51(1):62-70 23731819 - J Crit Care. 2013 Oct;28(5):586-96 18379235 - Crit Care Med. 2008 Apr;36(4):1114-8 23651716 - Dan Med J. 2013 Apr;60(4):A4606 21346161 - Anesth Analg. 2011 Jun;112(6):1289-95 21814104 - J Trauma. 2011 Aug;71(2 Suppl 3):S358-63 23642914 - Lancet. 2013 Sep 14;382(9896):984-94 20035217 - Crit Care Med. 2010 Mar;38(3):771-8 20622621 - J Trauma. 2010 Jul;69 Suppl 1:S55-63 22438924 - PLoS One. 2012;7(3):e33403 19630915 - Scand J Immunol. 2009 Aug;70(2):101-5 24117772 - Transfusion. 2014 Apr;54(4):1114-24 19560161 - J Surg Res. 2011 Jan;165(1):136-41 19667872 - J Trauma. 2009 Aug;67(2):221-7; discussion 228-30 21392760 - Injury. 2011 Jul;42(7):697-701 22117051 - Blood. 2012 Feb 16;119(7):1757-67 22824931 - Crit Care Med. 2012 Oct;40(10):2813-20 22060800 - Transfusion. 2012 May;52(5):946-52 21846911 - Am J Clin Pathol. 2011 Sep;136(3):364-70 23807246 - Shock. 2013 Sep;40(3):195-202 15383020 - Transfusion. 2004 Oct;44(10):1468-74 16772606 - Blood. 2006 Oct 1;108(7):2455-62 16276195 - Crit Care Med. 2005 Nov;33(11):2667-71 18090009 - J Trauma. 2007 Oct;63(4):805-13 20956766 - Arch Surg. 2010 Oct;145(10):973-7 23672421 - Transfusion. 2013 Oct;53(10):2222-9 1600757 - Chest. 1992 Jun;101(6):1481-3 21762464 - Transfusion. 2012 Jan;52(1):160-5 21886795 - PLoS One. 2011;6(8):e23530 11816725 - Thromb Haemost. 2001 Nov;86(5):1327-30 12818969 - Anesth Analg. 2003 Jul;97(1):216-21, table of contents 19001962 - J Trauma. 2008 Nov;65(5):986-93 24158192 - J Trauma Acute Care Surg. 2013 Nov;75(5):759-66 11948062 - Chest. 2002 Apr;121(4):1262-8 16430944 - Thromb Res. 2006;118(6):723-31 18791365 - Ann Surg. 2008 Sep;248(3):447-58 |
| References_xml | – volume: 86 start-page: 1327 year: 2001 ident: 828_CR29 publication-title: Thromb Haemost doi: 10.1055/s-0037-1616068 – volume: 70 start-page: 101 year: 2009 ident: 828_CR34 publication-title: Scand J Immunol doi: 10.1111/j.1365-3083.2009.02278.x – volume: 52 start-page: 946 year: 2012 ident: 828_CR42 publication-title: Transfusion doi: 10.1111/j.1537-2995.2011.03403.x – volume: 12 start-page: 266 year: 2011 ident: 828_CR27 publication-title: Trials doi: 10.1186/1745-6215-12-266 – volume: 145 start-page: 973 year: 2010 ident: 828_CR11 publication-title: Arch Surg doi: 10.1001/archsurg.2010.216 – volume: 60 start-page: A4606 year: 2013 ident: 828_CR5 publication-title: Dan Med J – volume: 248 start-page: 447 year: 2008 ident: 828_CR17 publication-title: Ann Surg doi: 10.1097/SLA.0b013e318185a9ad – volume: 69 start-page: S55 year: 2011 ident: 828_CR35 publication-title: J Trauma – volume: 42 start-page: 697 year: 2011 ident: 828_CR21 publication-title: Injury doi: 10.1016/j.injury.2010.12.015 – volume: 165 start-page: 136 year: 2011 ident: 828_CR24 publication-title: J Surg Res doi: 10.1016/j.jss.2009.04.034 – volume: 7 year: 2012 ident: 828_CR33 publication-title: PLoS One doi: 10.1371/journal.pone.0033403 – volume: 33 start-page: 2667 year: 2005 ident: 828_CR4 publication-title: Crit Care Med doi: 10.1097/01.CCM.0000186745.53059.F0 – volume: 40 start-page: 2813 year: 2012 ident: 828_CR14 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e31825b8e20 – volume: 36 start-page: 1114 year: 2008 ident: 828_CR12 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e318168f89d – volume: 40 start-page: 195 year: 2013 ident: 828_CR26 publication-title: Shock doi: 10.1097/SHK.0b013e31829f91fc – volume: 63 start-page: 805 year: 2007 ident: 828_CR40 publication-title: J Trauma – volume: 163 start-page: 317 year: 2010 ident: 828_CR15 publication-title: J Surg Res doi: 10.1016/j.jss.2010.04.049 – volume: 119 start-page: 1757 year: 2012 ident: 828_CR13 publication-title: Blood doi: 10.1182/blood-2011-08-370932 – volume: 118 start-page: 723 year: 2006 ident: 828_CR30 publication-title: Thromb Res doi: 10.1016/j.thromres.2005.12.006 – volume: 75 start-page: 759 year: 2013 ident: 828_CR38 publication-title: J Trauma Acute Care Surg doi: 10.1097/TA.0b013e3182a92514 – volume: 51 start-page: 338 year: 2011 ident: 828_CR9 publication-title: Transfusion doi: 10.1111/j.1537-2995.2010.02816.x – volume: 67 start-page: 221 year: 2009 ident: 828_CR8 publication-title: J Trauma – volume: 136 start-page: 364 year: 2011 ident: 828_CR19 publication-title: Am J Clin Pathol doi: 10.1309/AJCPH16YXJEFSHEO – volume: 38 start-page: 771 year: 2010 ident: 828_CR6 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e3181cc4d4b – volume: 382 start-page: 984 year: 2013 ident: 828_CR16 publication-title: Lancet doi: 10.1016/S0140-6736(12)62197-7 – volume: 126 start-page: 11 year: 2004 ident: 828_CR3 publication-title: Br J Haematol doi: 10.1111/j.1365-2141.2004.04972.x – volume: 101 start-page: 1481 year: 1992 ident: 828_CR28 publication-title: Chest doi: 10.1378/chest.101.6.1481 – volume: 114 start-page: 3033 year: 2009 ident: 828_CR22 publication-title: Blood doi: 10.1182/blood-2009-02-204966 – volume: 54 start-page: 1114 year: 2014 ident: 828_CR20 publication-title: Transfusion doi: 10.1111/trf.12422 – volume: 51 start-page: 62 year: 2011 ident: 828_CR1 publication-title: Transfusion doi: 10.1111/j.1537-2995.2010.02798.x – volume: 112 start-page: 1289 year: 2011 ident: 828_CR39 publication-title: Anesth Analg doi: 10.1213/ANE.0b013e318210385c – volume: 121 start-page: 1262 year: 2002 ident: 828_CR32 publication-title: Chest doi: 10.1378/chest.121.4.1262 – volume: 97 start-page: 216 year: 2003 ident: 828_CR36 publication-title: Anesth Analg – volume: 6 year: 2011 ident: 828_CR23 publication-title: PLoS One – volume: 65 start-page: 986 year: 2008 ident: 828_CR41 publication-title: J Trauma – volume: 53 start-page: 2222 year: 2013 ident: 828_CR2 publication-title: Transfusion doi: 10.1111/trf.12231 – volume: 52 start-page: 160 year: 2012 ident: 828_CR10 publication-title: Transfusion doi: 10.1111/j.1537-2995.2011.03247.x – volume: 28 start-page: 586 year: 2013 ident: 828_CR25 publication-title: J Crit Care doi: 10.1016/j.jcrc.2013.04.010 – volume: 108 start-page: 2455 year: 2006 ident: 828_CR31 publication-title: Blood doi: 10.1182/blood-2006-04-017251 – volume: 53 start-page: 80S year: 2013 ident: 828_CR37 publication-title: Transfusion doi: 10.1111/trf.12040 – volume: 44 start-page: 1468 year: 2004 ident: 828_CR7 publication-title: Transfusion doi: 10.1111/j.1537-2995.2004.04053.x – volume: 71 start-page: S358 year: 2011 ident: 828_CR18 publication-title: J Trauma – reference: 18090009 - J Trauma. 2007 Oct;63(4):805-13 – reference: 20804532 - Transfusion. 2011 Jan;51(1):62-70 – reference: 16772606 - Blood. 2006 Oct 1;108(7):2455-62 – reference: 19638625 - Blood. 2009 Oct 1;114(14):3033-43 – reference: 22060800 - Transfusion. 2012 May;52(5):946-52 – reference: 23642914 - Lancet. 2013 Sep 14;382(9896):984-94 – reference: 24158192 - J Trauma Acute Care Surg. 2013 Nov;75(5):759-66 – reference: 18379235 - Crit Care Med. 2008 Apr;36(4):1114-8 – reference: 20599210 - J Surg Res. 2010 Oct;163(2):317-22 – reference: 24117772 - Transfusion. 2014 Apr;54(4):1114-24 – reference: 21814104 - J Trauma. 2011 Aug;71(2 Suppl 3):S358-63 – reference: 20956766 - Arch Surg. 2010 Oct;145(10):973-7 – reference: 19630915 - Scand J Immunol. 2009 Aug;70(2):101-5 – reference: 21762464 - Transfusion. 2012 Jan;52(1):160-5 – reference: 23731819 - J Crit Care. 2013 Oct;28(5):586-96 – reference: 22438924 - PLoS One. 2012;7(3):e33403 – reference: 15198728 - Br J Haematol. 2004 Jul;126(1):11-28 – reference: 23807246 - Shock. 2013 Sep;40(3):195-202 – reference: 21346161 - Anesth Analg. 2011 Jun;112(6):1289-95 – reference: 23651716 - Dan Med J. 2013 Apr;60(4):A4606 – reference: 23301978 - Transfusion. 2013 Jan;53 Suppl 1:80S-90S – reference: 18791365 - Ann Surg. 2008 Sep;248(3):447-58 – reference: 19667872 - J Trauma. 2009 Aug;67(2):221-7; discussion 228-30 – reference: 22824931 - Crit Care Med. 2012 Oct;40(10):2813-20 – reference: 21846911 - Am J Clin Pathol. 2011 Sep;136(3):364-70 – reference: 23672421 - Transfusion. 2013 Oct;53(10):2222-9 – reference: 16276195 - Crit Care Med. 2005 Nov;33(11):2667-71 – reference: 20035217 - Crit Care Med. 2010 Mar;38(3):771-8 – reference: 21392760 - Injury. 2011 Jul;42(7):697-701 – reference: 15383020 - Transfusion. 2004 Oct;44(10):1468-74 – reference: 21886795 - PLoS One. 2011;6(8):e23530 – reference: 11816725 - Thromb Haemost. 2001 Nov;86(5):1327-30 – reference: 1600757 - Chest. 1992 Jun;101(6):1481-3 – reference: 20622621 - J Trauma. 2010 Jul;69 Suppl 1:S55-63 – reference: 22196464 - Trials. 2011;12:266 – reference: 20723173 - Transfusion. 2011 Feb;51(2):338-43 – reference: 11948062 - Chest. 2002 Apr;121(4):1262-8 – reference: 16430944 - Thromb Res. 2006;118(6):723-31 – reference: 12818969 - Anesth Analg. 2003 Jul;97(1):216-21, table of contents – reference: 19560161 - J Surg Res. 2011 Jan;165(1):136-41 – reference: 19001962 - J Trauma. 2008 Nov;65(5):986-93 – reference: 22117051 - Blood. 2012 Feb 16;119(7):1757-67 |
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Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects... Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects of FFP have... Introduction Much controversy exists on the effect of a fresh frozen plasma (FFP) transfusion on systemic inflammation and endothelial damage. Adverse effects... Abbreviations ADAMTS13: a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 APACHE IV score: acute physiology and chronic health... |
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| SubjectTerms | Acute respiratory distress syndrome Analysis Blood coagulation factor VIII Blood Component Transfusion - methods Blood products Care and treatment Critical care Critical Care Medicine Critical Illness - therapy Cytokines Emergency Medicine Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Evidence-based medicine Health aspects Health risk assessment Heart surgery Humans Inflammation Inflammation - complications Inflammation - etiology Intensive Intensive care Intensive Care Units - utilization International Normalized Ratio Ligands Medicine & Public Health Mortality Multiple organ dysfunction syndrome Netherlands Patients Permeability Plasma Plasma - drug effects Plasma - metabolism Prospective Studies Risk factors Trauma Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF Von Willebrand factor |
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| Title | Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial |
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