Identification of a cell of origin for human prostate cancer

Luminal cells are believed to be the cells of origin for human prostate cancer, because the disease is characterized by luminal cell expansion and the absence of basal cells. Yet functional studies addressing the origin of human prostate cancer have not previously been reported because of a lack of...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 329; H. 5991; S. 568
Hauptverfasser:	Goldstein, Andrew S, Huang, Jiaoti, Guo, Changyong, Garraway, Isla P, Witte, Owen N
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.07.2010
Schlagworte:	Animals Biomarkers, Tumor - metabolism Cell Separation Cell Transformation, Neoplastic Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium - pathology Flow Cytometry Humans Keratins - analysis Male Mice Mice, Inbred NOD Mice, SCID Prostate - cytology Prostate - metabolism Prostate - pathology Prostatic Intraepithelial Neoplasia - metabolism Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-akt - metabolism Receptors, Androgen - metabolism Trans-Activators - metabolism Transcriptional Regulator ERG Transduction, Genetic
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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