Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all

The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, a...

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Veröffentlicht in:Radiation oncology (London, England) Jg. 10; H. 1; S. 165
Hauptverfasser: Oei, Arlene L., Vriend, Lianne E. M., Crezee, Johannes, Franken, Nicolaas A. P., Krawczyk, Przemek M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 07.08.2015
BioMed Central Ltd
Springer Nature B.V
Schlagworte:
Animals
Antineoplastic Agents - pharmacology
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Chemotherapy
Clinical Radiation Oncology
DNA
DNA damage
DNA Damage - drug effects
DNA Damage - physiology
DNA repair
DNA Repair - physiology
Drug resistance
Genetic aspects
Health aspects
Humans
Hyperthermia, Induced
Imaging
Ionizing radiation
Mediation
Neoplasms - therapy
Oncology
Radiology
Radiotherapy
Chemotherapy
Hyperthermia
DNA repair
DNA damage
ISSN:1748-717X, 1748-717X
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Zusammenfassung:The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, anti-cancer treatments based on inflicting DNA damage can benefit from inhibition of DNA repair. Hyperthermia – treatment at elevated temperature – considerably affects DNA repair, among other cellular processes, and can thus sensitize (cancer) cells to DNA damaging agents. This effect has been known and clinically applied for many decades, but how heat inhibits DNA repair and which pathways are targeted has not been fully elucidated. In this review we attempt to summarize the known effects of hyperthermia on DNA repair pathways relevant in clinical treatment of cancer. Furthermore, we outline the relationships between the effects of heat on DNA repair and sensitization of cells to various DNA damaging agents.
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ISSN:1748-717X
1748-717X
DOI:10.1186/s13014-015-0462-0