MicroRNA delivery through nanoparticles

MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This revi...

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Vydáno v:Journal of controlled release Ročník 313; s. 80 - 95
Hlavní autoři: Lee, Sharon Wei Ling, Paoletti, Camilla, Campisi, Marco, Osaki, Tatsuya, Adriani, Giulia, Kamm, Roger D., Mattu, Clara, Chiono, Valeria
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 10.11.2019
Elsevier Science Publishers
Témata:
Animals
Biocompatible Materials - chemistry
Biomaterials
Delayed-Action Preparations - chemistry
engineering
etiology
Humans
Lipids - chemistry
Metal Nanoparticles - chemistry
microRNA
MicroRNA delivery and release
MicroRNAs - chemistry
Molecular Targeted Therapy
Nanocapsules - chemistry
nanocarriers
Nanoparticles
neoplasms
Neoplasms - genetics
Neoplasms - therapy
neurodegenerative diseases
Neurodegenerative Diseases - genetics
Neurodegenerative Diseases - therapy
Personalized medicine
Physicochemical characterization
Polymers - chemistry
Precision Medicine
Regeneration - genetics
Silicon Dioxide - chemistry
tissue repair
Transfection
Nanoparticles
MicroRNA delivery and release
Physicochemical characterization
Personalized medicine
Biomaterials
ISSN:0168-3659, 1873-4995, 1873-4995
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Shrnutí:MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
These authors equally contributed as first authors.
These authors equally contributed as last authors.
Present addresses.
ISSN:0168-3659
1873-4995
1873-4995
DOI:10.1016/j.jconrel.2019.10.007