MOG antibody seropositivity in a patient with encephalitis: beyond the classical syndrome

Background The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or opti...

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Vydané v:	BMC neurology Ročník 17; číslo 1; s. 190 - 6
Hlavní autori:	Mariotto, Sara, Monaco, Salvatore, Peschl, Patrick, Coledan, Ilaria, Mazzi, Romualdo, Höftberger, Romana, Reindl, Markus, Ferrari, Sergio
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London BioMed Central 05.10.2017 BioMed Central Ltd Springer Nature B.V BMC
Predmet:	Adult Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-abs) Ataxia Autoantibodies Autoantibodies - blood Autoimmune diseases Care and treatment Case Report Case studies Causes of Central nervous system Cerebrospinal fluid Consciousness Consortia Cortex Demyelinating diseases Diagnosis Encephalitis Encephalitis - immunology Family medical history Fever Genetic aspects Humans Immunoglobulins Immunoglobulins, Intravenous - administration & dosage Inflammation Intravenous administration Magnetic Resonance Imaging Male Medicine Medicine & Public Health Multiple sclerosis Myelin Myelin proteins Myelin-Oligodendrocyte Glycoprotein - immunology Myelitis Nervous system Neuritis Neurochemistry Neuroimaging Neurology Neurosurgery NMR Nuclear magnetic resonance Oligodendrocyte-myelin glycoprotein Optic neuritis Optic Neuritis - etiology Patients Pediatrics Physiological aspects Prognosis Substantia alba Italy Austria Anti-myelin oligodendrocyte glycoprotein antibodies (MOG-abs) Autoimmune diseases Encephalitis
ISSN:	1471-2377, 1471-2377
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Shrnutí:	Background The presence of circulating anti-myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) has been described in sera of patients with different inflammatory conditions of the central nervous system. In adults the core clinical feature is usually characterised by acute myelitis and/or optic neuritis. We here report an atypical case with serum and cerebrospinal fluid MOG-Abs and a clinical picture suggestive for acute encephalitis. Case presentation A 31-year-old Indian man presented with altered mental status, slight fever, and ataxia. Brain magnetic resonance imaging noted a widespread involvement of the white matter associated with slight cortical and subcortical damage in absence of contrast enhancement. An extensive infectious screening resulted negative while autoimmune analysis revealed the presence of MOG-Abs, detected with live cell-based assay. After treatment with intravenous immunoglobulins a marked and prompt clinical and radiological improvement was observed. Conclusions To date, several areas of uncertainty still remain regarding clinical features and prognosis of subjects with MOG-Abs. The description of atypical cases is crucial, since recognition of this condition leads to prompt treatment and better prognosis, as in the case here reported.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	1471-2377 1471-2377
DOI:	10.1186/s12883-017-0971-6