Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing
Background Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the...
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| Vydané v: | BMC gastroenterology Ročník 15; číslo 1; s. 100 |
|---|---|
| Hlavní autori: | , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
BioMed Central
11.08.2015
BioMed Central Ltd Springer Nature B.V |
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| ISSN: | 1471-230X, 1471-230X |
| On-line prístup: | Získať plný text |
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| Abstract | Background
Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity.
Methods
Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m
2
) and 33 obese subjects (BMI ≥25 kg/m
2
) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis.
Results
T-RFLP analysis showed significantly reduced numbers of
Bacteroidetes
and a higher
Firmicutes
to
Bacteroidetes
ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese:
Blautia hydrogenotorophica
,
Coprococcus catus
,
Eubacterium ventriosum
,
Ruminococcus bromii
,
Ruminococcus obeum
; non-obese:
Bacteroides faecichinchillae
,
Bacteroides thetaiotaomicron
,
Blautia wexlerae
,
Clostridium bolteae
,
Flavonifractor plautii
).
Conclusion
Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. |
|---|---|
| AbstractList | Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity.BACKGROUNDObesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity.Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m(2)) and 33 obese subjects (BMI ≥25 kg/m(2)) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis.METHODSStool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m(2)) and 33 obese subjects (BMI ≥25 kg/m(2)) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis.T-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica, Coprococcus catus, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum; non-obese: Bacteroides faecichinchillae, Bacteroides thetaiotaomicron, Blautia wexlerae, Clostridium bolteae, Flavonifractor plautii).RESULTST-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica, Coprococcus catus, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum; non-obese: Bacteroides faecichinchillae, Bacteroides thetaiotaomicron, Blautia wexlerae, Clostridium bolteae, Flavonifractor plautii).Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity.CONCLUSIONGut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. Background Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity. Methods Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m 2 ) and 33 obese subjects (BMI ≥25 kg/m 2 ) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis. Results T-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica , Coprococcus catus , Eubacterium ventriosum , Ruminococcus bromii , Ruminococcus obeum ; non-obese: Bacteroides faecichinchillae , Bacteroides thetaiotaomicron , Blautia wexlerae , Clostridium bolteae , Flavonifractor plautii ). Conclusion Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity. Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m.sup.2) and 33 obese subjects (BMI [greater than or equai to]25 kg/m.sup.2) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis. T-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica, Coprococcus catus, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum; non-obese: Bacteroides faecichinchillae, Bacteroides thetaiotaomicron, Blautia wexlerae, Clostridium bolteae, Flavonifractor plautii). Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. Background Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity. Methods Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m2) and 33 obese subjects (BMI ≥25 kg/m2) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis. Results T-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica, Coprococcus catus, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum; non-obese: Bacteroides faecichinchillae, Bacteroides thetaiotaomicron, Blautia wexlerae, Clostridium bolteae, Flavonifractor plautii). Conclusion Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity. Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m(2)) and 33 obese subjects (BMI ≥25 kg/m(2)) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis. T-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica, Coprococcus catus, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum; non-obese: Bacteroides faecichinchillae, Bacteroides thetaiotaomicron, Blautia wexlerae, Clostridium bolteae, Flavonifractor plautii). Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. Background Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has recently attracted the attention of many researchers. Although the gut microbiota was long thought to contribute to obesity, the exact association remains largely unknown. We examined the human gut microbiota composition in a Japanese population in order to determine its relationship to obesity. Methods Stool samples from 23 non-obese subjects (body mass index [BMI] <20 kg/m.sup.2) and 33 obese subjects (BMI [greater than or equai to]25 kg/m.sup.2) were collected and DNA was extracted prior to colonoscopy. After terminal restriction fragment length polymorphism (T-RFLP) analysis, samples from 10 subjects (4 non-obese and 6 obese) were selected and subjected to next-generation sequencing for species-level analysis. Results T-RFLP analysis showed significantly reduced numbers of Bacteroidetes and a higher Firmicutes to Bacteroidetes ratio in obese subjects compared with non-obese subjects. Bacterial diversity was significantly greater in obese subjects compared with non-obese subjects. Next-generation sequencing revealed that obese and non-obese subjects had different gut microbiota compositions and that certain bacterial species were significantly associated with each group (obese: Blautia hydrogenotorophica, Coprococcus catus, Eubacterium ventriosum, Ruminococcus bromii, Ruminococcus obeum; non-obese: Bacteroides faecichinchillae, Bacteroides thetaiotaomicron, Blautia wexlerae, Clostridium bolteae, Flavonifractor plautii). Conclusion Gut microbial properties differ between obese and non-obese subjects in Japan, suggesting that gut microbiota composition is related to obesity. Keywords: Obesity, Microbiota, T-RFLP, Next-generation sequencing |
| ArticleNumber | 100 |
| Audience | Academic |
| Author | Tanaka, Junichiro Takei, Yoshiyuki Moritani, Isao Ito, Masaaki Sugimoto, Kazushi Oya, Yumi Kasai, Chika Tameda, Masahiko Shiraki, Katsuya Takase, Kojiro Inoue, Hidekazu |
| Author_xml | – sequence: 1 givenname: Chika surname: Kasai fullname: Kasai, Chika organization: Department of Gastroenterology, Mie Prefectural General Medical Center – sequence: 2 givenname: Kazushi surname: Sugimoto fullname: Sugimoto, Kazushi email: kazushi@clin.medic.mie-u.ac.jp organization: Department of Molecular and Laboratory Medicine, Mie University School of Medicine, Department of Gastroenterology and Hepatology, Mie University School of Medicine – sequence: 3 givenname: Isao surname: Moritani fullname: Moritani, Isao organization: Department of Gastroenterology, Mie Prefectural General Medical Center – sequence: 4 givenname: Junichiro surname: Tanaka fullname: Tanaka, Junichiro organization: Department of Gastroenterology, Mie Prefectural General Medical Center – sequence: 5 givenname: Yumi surname: Oya fullname: Oya, Yumi organization: Department of Gastroenterology, Mie Prefectural General Medical Center – sequence: 6 givenname: Hidekazu surname: Inoue fullname: Inoue, Hidekazu organization: Department of Gastroenterology, Mie Prefectural General Medical Center – sequence: 7 givenname: Masahiko surname: Tameda fullname: Tameda, Masahiko organization: Department of Molecular and Laboratory Medicine, Mie University School of Medicine, Department of Gastroenterology and Hepatology, Mie University School of Medicine – sequence: 8 givenname: Katsuya surname: Shiraki fullname: Shiraki, Katsuya organization: Department of Gastroenterology and Hepatology, Mie University School of Medicine – sequence: 9 givenname: Masaaki surname: Ito fullname: Ito, Masaaki organization: Department of Cardiology and Nephrology – sequence: 10 givenname: Yoshiyuki surname: Takei fullname: Takei, Yoshiyuki organization: Department of Gastroenterology and Hepatology, Mie University School of Medicine – sequence: 11 givenname: Kojiro surname: Takase fullname: Takase, Kojiro organization: Department of Gastroenterology, Mie Prefectural General Medical Center |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26261039$$D View this record in MEDLINE/PubMed |
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Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and... Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and obesity has... Background Obesity has become one of the most serious social problems in developed countries, including Japan. The relationship between the gut microbiota and... |
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| SubjectTerms | Adult Asian People Bacteroidetes - genetics Bacteroidetes - isolation & purification Body Mass Index Care and treatment Colonoscopy Comparative analysis DNA, Bacterial - analysis Feces - microbiology Female Firmicutes - genetics Firmicutes - isolation & purification Gastroenterology Gastrointestinal Microbiome - genetics Gastrointestinal Tract - microbiology Genetic aspects Genetic polymorphisms Hepatology Humans Internal Medicine Japan Male Medicine Medicine & Public Health Microbiota (Symbiotic organisms) Middle Aged Obesity Obesity - microbiology Patient outcomes Polymorphism, Restriction Fragment Length Research Article Sequence Analysis, DNA - methods |
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| Title | Comparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing |
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