Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis
Background Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years. Methods We performed a systematic review and meta-analysis of studies on neurosarco...
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| Vydáno v: | BMC neurology Ročník 16; číslo 1; s. 220 |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
London
BioMed Central
15.11.2016
BioMed Central Ltd Springer Nature B.V |
| Témata: | |
| ISSN: | 1471-2377, 1471-2377 |
| On-line přístup: | Získat plný text |
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| Abstract | Background
Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years.
Methods
We performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases. Studies describing one specific neurological presentation were excluded.
Results
We identified 29 articles describing 1088 patients diagnosed between 1965 and 2015. Neurosarcoidosis occurred in 5% of patients with systemic sarcoidosis. Mean age at presentation was 43 years and neurological symptoms were the first clinical manifestation of sarcoidosis in 52%. The most commonly reported feature of neurosarcoidosis was cranial neuropathy in 55%, with the facial and optic nerve most commonly affected, followed by headache in 32%. Pleiocytosis and elevated CSF protein were found in 58 and 63%. MRI of the brain showed abnormalities in 70%. Chest X-ray, chest CT, or gallium-67-scintigraphy showed findings consistent with sarcoidosis in 60%, 70% and 69%, respectively. First line therapy with corticosteroids was initiated in 434 of 539 patients (81%). Second and third line therapy was started in 27 and 9%. Outcome consisted of complete remission in 27%, incomplete remission in 32%, stable disease in 24%, deterioration in 6% and death in 5%.
Conclusion
Neurosarcoidosis has a heterogeneous clinical presentation and the diagnosis can be difficult because of low sensitivity of ancillary investigations. New treatments have emerged, but nevertheless one third of patients do not respond to treatment. Prospective cohort studies and RCTs on treatment are urgently needed. |
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| AbstractList | Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years.
We performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases. Studies describing one specific neurological presentation were excluded.
We identified 29 articles describing 1088 patients diagnosed between 1965 and 2015. Neurosarcoidosis occurred in 5% of patients with systemic sarcoidosis. Mean age at presentation was 43 years and neurological symptoms were the first clinical manifestation of sarcoidosis in 52%. The most commonly reported feature of neurosarcoidosis was cranial neuropathy in 55%, with the facial and optic nerve most commonly affected, followed by headache in 32%. Pleiocytosis and elevated CSF protein were found in 58 and 63%. MRI of the brain showed abnormalities in 70%. Chest X-ray, chest CT, or gallium-67-scintigraphy showed findings consistent with sarcoidosis in 60%, 70% and 69%, respectively. First line therapy with corticosteroids was initiated in 434 of 539 patients (81%). Second and third line therapy was started in 27 and 9%. Outcome consisted of complete remission in 27%, incomplete remission in 32%, stable disease in 24%, deterioration in 6% and death in 5%.
Neurosarcoidosis has a heterogeneous clinical presentation and the diagnosis can be difficult because of low sensitivity of ancillary investigations. New treatments have emerged, but nevertheless one third of patients do not respond to treatment. Prospective cohort studies and RCTs on treatment are urgently needed. Background Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years. Methods We performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases. Studies describing one specific neurological presentation were excluded. Results We identified 29 articles describing 1088 patients diagnosed between 1965 and 2015. Neurosarcoidosis occurred in 5% of patients with systemic sarcoidosis. Mean age at presentation was 43 years and neurological symptoms were the first clinical manifestation of sarcoidosis in 52%. The most commonly reported feature of neurosarcoidosis was cranial neuropathy in 55%, with the facial and optic nerve most commonly affected, followed by headache in 32%. Pleiocytosis and elevated CSF protein were found in 58 and 63%. MRI of the brain showed abnormalities in 70%. Chest X-ray, chest CT, or gallium-67-scintigraphy showed findings consistent with sarcoidosis in 60%, 70% and 69%, respectively. First line therapy with corticosteroids was initiated in 434 of 539 patients (81%). Second and third line therapy was started in 27 and 9%. Outcome consisted of complete remission in 27%, incomplete remission in 32%, stable disease in 24%, deterioration in 6% and death in 5%. Conclusion Neurosarcoidosis has a heterogeneous clinical presentation and the diagnosis can be difficult because of low sensitivity of ancillary investigations. New treatments have emerged, but nevertheless one third of patients do not respond to treatment. Prospective cohort studies and RCTs on treatment are urgently needed. BACKGROUNDNeurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years.METHODSWe performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases. Studies describing one specific neurological presentation were excluded.RESULTSWe identified 29 articles describing 1088 patients diagnosed between 1965 and 2015. Neurosarcoidosis occurred in 5% of patients with systemic sarcoidosis. Mean age at presentation was 43 years and neurological symptoms were the first clinical manifestation of sarcoidosis in 52%. The most commonly reported feature of neurosarcoidosis was cranial neuropathy in 55%, with the facial and optic nerve most commonly affected, followed by headache in 32%. Pleiocytosis and elevated CSF protein were found in 58 and 63%. MRI of the brain showed abnormalities in 70%. Chest X-ray, chest CT, or gallium-67-scintigraphy showed findings consistent with sarcoidosis in 60%, 70% and 69%, respectively. First line therapy with corticosteroids was initiated in 434 of 539 patients (81%). Second and third line therapy was started in 27 and 9%. Outcome consisted of complete remission in 27%, incomplete remission in 32%, stable disease in 24%, deterioration in 6% and death in 5%.CONCLUSIONNeurosarcoidosis has a heterogeneous clinical presentation and the diagnosis can be difficult because of low sensitivity of ancillary investigations. New treatments have emerged, but nevertheless one third of patients do not respond to treatment. Prospective cohort studies and RCTs on treatment are urgently needed. Background Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients with neurosarcoidosis over the last 35 years. Methods We performed a systematic review and meta-analysis of studies on neurosarcoidosis published between 1980 and 2016. Studies were included if they reported at least 5 cases. Studies describing one specific neurological presentation were excluded. Results We identified 29 articles describing 1088 patients diagnosed between 1965 and 2015. Neurosarcoidosis occurred in 5% of patients with systemic sarcoidosis. Mean age at presentation was 43 years and neurological symptoms were the first clinical manifestation of sarcoidosis in 52%. The most commonly reported feature of neurosarcoidosis was cranial neuropathy in 55%, with the facial and optic nerve most commonly affected, followed by headache in 32%. Pleiocytosis and elevated CSF protein were found in 58 and 63%. MRI of the brain showed abnormalities in 70%. Chest X-ray, chest CT, or gallium-67-scintigraphy showed findings consistent with sarcoidosis in 60%, 70% and 69%, respectively. First line therapy with corticosteroids was initiated in 434 of 539 patients (81%). Second and third line therapy was started in 27 and 9%. Outcome consisted of complete remission in 27%, incomplete remission in 32%, stable disease in 24%, deterioration in 6% and death in 5%. Conclusion Neurosarcoidosis has a heterogeneous clinical presentation and the diagnosis can be difficult because of low sensitivity of ancillary investigations. New treatments have emerged, but nevertheless one third of patients do not respond to treatment. Prospective cohort studies and RCTs on treatment are urgently needed. |
| ArticleNumber | 220 |
| Audience | Academic |
| Author | Fritz, Daan van de Beek, Diederik Brouwer, Matthijs C. |
| Author_xml | – sequence: 1 givenname: Daan surname: Fritz fullname: Fritz, Daan organization: Department of Neurology, Academic Medical Centre, Amsterdam Neuroscience – sequence: 2 givenname: Diederik surname: van de Beek fullname: van de Beek, Diederik organization: Department of Neurology, Academic Medical Centre, Amsterdam Neuroscience – sequence: 3 givenname: Matthijs C. surname: Brouwer fullname: Brouwer, Matthijs C. email: m.c.brouwer@amc.uva.nl organization: Department of Neurology, Academic Medical Centre, Amsterdam Neuroscience |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27846819$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1378/chest.112.1.220 10.1159/000366199 10.1164/rccm.200603-402OC 10.1093/qjmed/92.2.103 10.1111/j.1600-0420.2004.00348.x 10.1097/NRL.0b013e3182704d04 10.1056/NEJMra071714 10.3174/ajnr.A1470 10.1136/jnnp.2008.151977 10.1001/jama.289.24.3300 10.1097/MD.0000000000003277 10.1212/WNL.57.5.927 10.1093/qjmed/hcp042 10.1016/S0140-6736(14)60720-0 10.1001/archinte.1997.00440370104011 10.1159/000076534 10.1097/WCO.0b013e3283608459 10.1007/s00415-010-5623-3 10.1055/s-0034-1390387 10.1007/s00415-005-0043-5 10.1097/MAO.0000000000000501 10.1016/S0035-3787(05)85176-8 10.1111/j.1600-0404.1986.tb03277.x 10.1001/archneur.1985.04060080095022 10.5152/npa.2015.7318 10.1016/S1474-4422(04)00805-1 10.1016/j.semarthrit.2004.07.011 10.1056/NEJMra1104650 10.1007/s11940-013-0242-9 10.1097/00005792-199009000-00001 10.1016/j.ejim.2011.08.019 |
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| Keywords | Systematic review Auto-immune disease Neurosarcoidosis Clinical neurology Systemic disease Meta-analysis |
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| References | VA Briner (741_CR21) 1998; 128 RK Allen (741_CR6) 2003; 20 K Nozaki (741_CR3) 2013; 15 S Marangoni (741_CR9) 2006; 253 S Pawate (741_CR29) 2009; 102 SE Leonhard (741_CR36) 2016; 95 JO Tavee (741_CR10) 2014; 20 RP Baughman (741_CR41) 2006; 174 EE Lower (741_CR19) 1997; 157 OP Sharma (741_CR20) 1997; 112 D Ferriby (741_CR23) 2001; 57 JH Stone (741_CR39) 2012; 366 A Karouache (741_CR26) 2005; 161 P Pavese (741_CR22) 1999; 28 S Wegener (741_CR35) 2015; 73 C Chapelon (741_CR16) 1990; 69 A Radziwill (741_CR18) 1995; 66 V Oksanen (741_CR14) 1986; 73 A Zouaoui (741_CR17) 1992; 19 RC Chen (741_CR15) 1989; 26 ML Carlson (741_CR33) 2015; 36 G Gozubatik-Celik (741_CR34) 2015; 52 R Shah (741_CR30) 2009; 30 JP Zajicek (741_CR8) 1999; 92 R Elkin (741_CR11) 1985; 67 KW Thomas (741_CR2) 2003; 289 A Dispenzieri (741_CR37) 2013; 27 TS Spencer (741_CR27) 2005; 34 K Heuser (741_CR24) 2004; 82 E Hoitsma (741_CR5) 2004; 3 B Pentland (741_CR12) 1985; 56 BM Segal (741_CR4) 2013; 26 HF Petereit (741_CR40) 2010; 257 C Kellinghaus (741_CR25) 2004; 51 FG Joseph (741_CR28) 2009; 80 J Gascon-Bayarri (741_CR31) 2011; 22 MC Iannuzzi (741_CR1) 2007; 357 K Nozaki (741_CR32) 2012; 18 T Kamisawa (741_CR38) 2015; 385 SP Agnihotri (741_CR7) 2014; 34 BJ Stern (741_CR13) 1985; 42 |
| References_xml | – volume: 112 start-page: 220 issue: 1 year: 1997 ident: 741_CR20 publication-title: Chest doi: 10.1378/chest.112.1.220 – volume: 73 start-page: 71 issue: 1–2 year: 2015 ident: 741_CR35 publication-title: Eur Neurol doi: 10.1159/000366199 – volume: 174 start-page: 795 issue: 7 year: 2006 ident: 741_CR41 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200603-402OC – volume: 20 start-page: 118 issue: 2 year: 2003 ident: 741_CR6 publication-title: Sarcoidosis Vasc Diffuse Lung Dis – volume: 92 start-page: 103 issue: 2 year: 1999 ident: 741_CR8 publication-title: QJM doi: 10.1093/qjmed/92.2.103 – volume: 128 start-page: 799 issue: 21 year: 1998 ident: 741_CR21 publication-title: Schweiz Med Wochenschr – volume: 82 start-page: 723 issue: 6 year: 2004 ident: 741_CR24 publication-title: Acta Ophthalmol Scand doi: 10.1111/j.1600-0420.2004.00348.x – volume: 18 start-page: 373 issue: 6 year: 2012 ident: 741_CR32 publication-title: Neurologist doi: 10.1097/NRL.0b013e3182704d04 – volume: 357 start-page: 2153 issue: 21 year: 2007 ident: 741_CR1 publication-title: N Engl J Med doi: 10.1056/NEJMra071714 – volume: 66 start-page: 915 issue: 12 year: 1995 ident: 741_CR18 publication-title: Nervenarzt – volume: 30 start-page: 953 issue: 5 year: 2009 ident: 741_CR30 publication-title: AJNR Am J Neuroradiol doi: 10.3174/ajnr.A1470 – volume: 80 start-page: 297 issue: 3 year: 2009 ident: 741_CR28 publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.2008.151977 – volume: 289 start-page: 3300 issue: 24 year: 2003 ident: 741_CR2 publication-title: JAMA doi: 10.1001/jama.289.24.3300 – volume: 95 issue: 14 year: 2016 ident: 741_CR36 publication-title: Medicine (Baltimore) doi: 10.1097/MD.0000000000003277 – volume: 28 start-page: 168 issue: 4 year: 1999 ident: 741_CR22 publication-title: Presse Med – volume: 19 start-page: 271 issue: 4 year: 1992 ident: 741_CR17 publication-title: J Neuroradiol – volume: 57 start-page: 927 issue: 5 year: 2001 ident: 741_CR23 publication-title: Neurology doi: 10.1212/WNL.57.5.927 – volume: 102 start-page: 449 issue: 7 year: 2009 ident: 741_CR29 publication-title: QJM doi: 10.1093/qjmed/hcp042 – volume: 385 start-page: 1460 issue: 9976 year: 2015 ident: 741_CR38 publication-title: Lancet doi: 10.1016/S0140-6736(14)60720-0 – volume: 26 start-page: 99 year: 1989 ident: 741_CR15 publication-title: Clin Exp Neurol – volume: 157 start-page: 1864 issue: 16 year: 1997 ident: 741_CR19 publication-title: Arch Intern Med doi: 10.1001/archinte.1997.00440370104011 – volume: 51 start-page: 84 issue: 2 year: 2004 ident: 741_CR25 publication-title: Eur Neurol doi: 10.1159/000076534 – volume: 26 start-page: 307 issue: 3 year: 2013 ident: 741_CR4 publication-title: Curr Opin Neurol doi: 10.1097/WCO.0b013e3283608459 – volume: 257 start-page: 1855 issue: 11 year: 2010 ident: 741_CR40 publication-title: J Neurol doi: 10.1007/s00415-010-5623-3 – volume: 34 start-page: 386 issue: 4 year: 2014 ident: 741_CR7 publication-title: Semin Neurol doi: 10.1055/s-0034-1390387 – volume: 253 start-page: 488 issue: 4 year: 2006 ident: 741_CR9 publication-title: J Neurol doi: 10.1007/s00415-005-0043-5 – volume: 20 start-page: 545 issue: 3 year: 2014 ident: 741_CR10 publication-title: Neurol Systemic Dis – volume: 36 start-page: 156 issue: 1 year: 2015 ident: 741_CR33 publication-title: Otol Neurotol doi: 10.1097/MAO.0000000000000501 – volume: 161 start-page: 1091 issue: 11 year: 2005 ident: 741_CR26 publication-title: Rev Neurol doi: 10.1016/S0035-3787(05)85176-8 – volume: 73 start-page: 283 issue: 3 year: 1986 ident: 741_CR14 publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.1986.tb03277.x – volume: 67 start-page: 943 issue: 23 year: 1985 ident: 741_CR11 publication-title: S Afr Med J – volume: 42 start-page: 909 issue: 9 year: 1985 ident: 741_CR13 publication-title: Arch Neurol doi: 10.1001/archneur.1985.04060080095022 – volume: 52 start-page: 102 issue: 1 year: 2015 ident: 741_CR34 publication-title: Noropsikiyatri Arsivi doi: 10.5152/npa.2015.7318 – volume: 27 start-page: 1242 issue: 12 year: 2013 ident: 741_CR37 publication-title: Oncology (Williston Park) – volume: 3 start-page: 397 issue: 7 year: 2004 ident: 741_CR5 publication-title: Lancet Neurol doi: 10.1016/S1474-4422(04)00805-1 – volume: 34 start-page: 649 issue: 4 year: 2005 ident: 741_CR27 publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2004.07.011 – volume: 366 start-page: 539 issue: 6 year: 2012 ident: 741_CR39 publication-title: N Engl J Med doi: 10.1056/NEJMra1104650 – volume: 15 start-page: 492 issue: 4 year: 2013 ident: 741_CR3 publication-title: Curr Treat Options Neurol doi: 10.1007/s11940-013-0242-9 – volume: 56 start-page: 457 issue: 220 year: 1985 ident: 741_CR12 publication-title: Q J Med – volume: 69 start-page: 261 issue: 5 year: 1990 ident: 741_CR16 publication-title: Medicine (Baltimore) doi: 10.1097/00005792-199009000-00001 – volume: 22 start-page: e125 issue: 6 year: 2011 ident: 741_CR31 publication-title: Eur J Intern Med doi: 10.1016/j.ejim.2011.08.019 |
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| Snippet | Background
Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome... Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome of patients... Background Neurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome... BACKGROUNDNeurosarcoidosis is a rare variant of sarcoidosis and is only described in small cohort studies. We define clinical features, treatment and outcome... |
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| SubjectTerms | Adult Care and treatment Central Nervous System Diseases CT imaging Demyelinating diseases Diagnosis Humans Magnetic resonance imaging Medicine Medicine & Public Health Neurochemistry Neurology Neurosurgery Patient outcomes Research Article Sarcoidosis |
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| Title | Clinical features, treatment and outcome in neurosarcoidosis: systematic review and meta-analysis |
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