Characteristics of diffuse retinal nerve fiber layer defects in red-free photographs as observed in optical coherence tomography en face images

Backgroud To determine whether diffuse retinal nerve fiber layer (RNFL) defects, identified on red-free fundus photographs, could be identified on optical coherence tomography (OCT) en face structural images and to evaluate which factors are related to the different recognition patterns on en face i...

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Bibliographic Details
Published in:BMC ophthalmology Vol. 20; no. 1; pp. 16 - 7
Main Authors: Lim, Abegaile Bartolome, Park, Ji-Hye, Jung, Jae Hoon, Yoo, Chungkwon, Kim, Yong Yeon
Format: Journal Article
Language:English
Published: London BioMed Central 08.01.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Subjects:
Adult
Age
Aged
Aged, 80 and over
Comparative analysis
Cross-Sectional Studies
Defects
Diagnostic imaging
Diffuse RNFL defect
En face image
Eye
Face
Female
Fluorescein Angiography
Glaucoma
Glaucoma, Open-Angle - diagnosis
Gonioscopy
Humans
Intraocular Pressure - physiology
Localized RNFL defect
Male
Medical equipment industry
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Nerve Fibers - pathology
OCT angiography
Open-angle glaucoma
Ophthalmology
Optics
Pattern recognition
Photography
Photography - methods
Receptive field
Red-free fundus photograph
Regression analysis
Research Article
Retina
Retinal Ganglion Cells - pathology
Retrospective Studies
Statistical analysis
Tomography
Tomography, Optical Coherence
Tonometry, Ocular
Visual Acuity - physiology
United States
Diffuse RNFL defect
OCT angiography
En face image
Red-free fundus photograph
Localized RNFL defect
ISSN:1471-2415, 1471-2415
Online Access:Get full text
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Description
Summary:Backgroud To determine whether diffuse retinal nerve fiber layer (RNFL) defects, identified on red-free fundus photographs, could be identified on optical coherence tomography (OCT) en face structural images and to evaluate which factors are related to the different recognition patterns on en face images. Methods This retrospective, cross-sectional study included open-angle glaucoma eyes with diffuse RNFL defects in the inferior hemifield, identified in red-free photographs. The corresponding OCT en face structural images were divided into 3 groups: (1) no defect, (2) localized defect, and (3) diffuse defect. We compared the demographic and clinical ocular characteristics among the groups. Results A total of 209 eyes from 157 patients were included. The distribution of OCT en face images was: no defect, 25 eyes (11.96%); localized defect, 106 eyes (50.72%); diffuse defect, 78 eyes (37.32%). Logistic regression analysis revealed that eyes with greater mean deviation ( P  = 0.004) and thicker inferior RNFL ( P  = 0.008) would be included in the no defect and localized defect groups based on OCT en face images, rather than in the diffuse defect group. Conclusion Around half of diffuse RNFL defects identified in the red-free photographs appeared as localized defects in OCT en face images. Mild glaucomatous damage was related to no defect and localized defect groups, classified based on the OCT en face images, in eyes with diffuse photographic RNFL defects. OCT en face images may be helpful in further assessing diffuse RNFL defects seen in red-free photographs in eyes with open-angle glaucoma.
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ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-019-1302-z