New loci associated with kidney function and chronic kidney disease

Caroline Fox and colleagues report results of a large genome-wide association meta-analysis and replication study for indices of renal function. Their work identifies 13 new loci associated with renal function and 7 loci associated with creatinine production and secretion. Chronic kidney disease (CK...

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Vydáno v:	Nature genetics Ročník 42; číslo 5; s. 376 - 384
Hlavní autoři:	Böger, Carsten A, Fuchsberger, Christian, Olden, Matthias, Glazer, Nicole L, Parsa, Afshin, Gao, Xiaoyi, Yang, Qiong, O'Connell, Jeffrey R, Li, Man, Tanaka, Toshiko, Isaacs, Aaron, Ketkar, Shamika, Dehghan, Abbas, Teumer, Alexander, Paré, Guillaume, Atkinson, Elizabeth J, Zeller, Tanja, Lohman, Kurt, Cornelis, Marilyn C, Probst-Hensch, Nicole M, Kronenberg, Florian, Tönjes, Anke, Hayward, Caroline, Aspelund, Thor, Eiriksdottir, Gudny, Rampersaud, Evadnie, Mitchell, Braxton D, Singleton, Andrew, Giallauria, Francesco, Metter, Jeffrey, de Boer, Ian H, Haritunians, Talin, Lumley, Thomas, Siscovick, David, Zillikens, M Carola, Oostra, Ben A, Feitosa, Mary, Province, Michael, de Andrade, Mariza, Turner, Stephen T, Schillert, Arne, Ziegler, Andreas, Schnabel, Renate B, Wilde, Sandra, Munzel, Thomas F, Leak, Tennille S, Klopp, Norman, Meisinger, Christa, Wichmann, H-Erich, Koenig, Wolfgang, Zgaga, Lina, Zemunik, Tatijana, Kolcic, Ivana, Hu, Frank B, Igl, Wilmar, Zaboli, Ghazal, Campbell, Harry, Ellinghaus, David, Aulchenko, Yurii S, Felix, Janine F, Rivadeneira, Fernando, Hofman, Albert, Imboden, Medea, Nitsch, Dorothea, Brandstätter, Anita, Stumvoll, Michael, Campbell, Susan, Endlich, Karlhans, Völzke, Henry, Nauck, Matthias, Völker, Uwe, Polasek, Ozren, Vitart, Veronique, Badola, Sunita, Parker, Alexander N, Ridker, Paul M, Blankenberg, Stefan, Liu, Yongmei, Curhan, Gary C, Franke, Andre, Paulweber, Bernhard, Prokopenko, Inga, Wang, Wei, Gudnason, Vilmundur, Shuldiner, Alan R, Coresh, Josef, Schmidt, Reinhold, Ferrucci, Luigi, Shlipak, Michael G, van Duijn, Cornelia M, Borecki, Ingrid, Gyllensten, Ulf, Wilson, James F, Witteman, Jacqueline C, Pramstaller, Peter P, Rettig, Rainer, Hastie, Nick, Kao, W H, Heid, Iris M, Fox, Caroline S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.05.2010 Nature Publishing Group
Témata:	631/208/205/2138 631/208/457/649 692/699/1585/104 Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cohort Studies Creatinine - blood Cystatin C - genetics Demographic aspects Diet Economic aspects Europe Fundamental and applied biological sciences. Psychology Gene Function Gene loci Genetic aspects Genetic Markers - genetics Genetic susceptibility Genetic variation Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Glomerular Filtration Rate Human Genetics Humans Kidney - physiology Kidney diseases Kidney Failure, Chronic - ethnology Kidney Failure, Chronic - genetics Kidneys Medical sciences MEDICIN MEDICINE Models, Genetic Mortality Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Population studies Public health Renal failure Renal function Risk Factors Solute transport Statistical methods Urinary system involvement in other diseases. Miscellaneous Europe United States Kidney disease Urinary system disease Urinary system Renal failure Chronic kidney disease Locus Kidney
ISSN:	1061-4036, 1546-1718, 1546-1718
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Shrnutí:	Caroline Fox and colleagues report results of a large genome-wide association meta-analysis and replication study for indices of renal function. Their work identifies 13 new loci associated with renal function and 7 loci associated with creatinine production and secretion. Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m 2 ; n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide–significant loci ( P < 5 × 10 −8 ) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9 ) and 7 loci suspected to affect creatinine production and secretion ( CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3 ). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/ng.568