CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA

Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by t...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Molecular cancer Ročník 14; číslo 1; s. 155
Hlavní autoři:	Conigliaro, Alice, Costa, Viviana, Lo Dico, Alessia, Saieva, Laura, Buccheri, Simona, Dieli, Francesco, Manno, Mauro, Raccosta, Samuele, Mancone, Carmine, Tripodi, Marco, De Leo, Giacomo, Alessandro, Riccardo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 14.08.2015 BioMed Central Ltd Springer Nature B.V
Témata:	Analysis Biomedical and Life Sciences Biomedicine Cancer cells Cancer Research Cell Adhesion Cell Line, Tumor Development and progression Endothelial Cells - metabolism Endothelium Exosomes - metabolism Genetic aspects Human Umbilical Vein Endothelial Cells - metabolism Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Metastasis Oncology Phenotype Physiological aspects RNA RNA, Long Noncoding - genetics Thy-1 Antigens - metabolism United Kingdom CD90+ liver cancer cells Angiogenesis Long-non-coding RNA H19 Exosomes
ISSN:	1476-4598, 1476-4598
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. Methods Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments. Results Exosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Conclusions Our data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma.
AbstractList	Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. Methods Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments. Results Exosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Conclusions Our data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments. Exosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Our data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. Methods Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments. Results Exosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Conclusions Our data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. BACKGROUNDCD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes.METHODSExosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments.RESULTSExosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells.CONCLUSIONSOur data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments. Exosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Our data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro models, already described as CD90+ liver cancer stem cells, our aim was to study their interaction with endothelial cells mediated by the release of exosomes. Methods Exosomes were isolated and characterized from both liver CD90+ cells and hepatoma cell lines. Endothelial cells were treated with exosomes, as well as transfected with a plasmid containing the full length sequence of the long non-coding RNA (lncRNA) H19. Molecular and functional analyses were done to characterize the endothelial phenotype after treatments. Results Exosomes released by CD90+ cancer cells, but not by parental hepatoma cells, modulated endothelial cells, promoting angiogenic phenotype and cell-to-cell adhesion. LncRNA profiling revealed that CD90+ cells were enriched in lncRNA H19, and released this through exosomes. Experiments of gain and loss of function of H19 showed that this LncRNA plays an important role in the exosome-mediated phenotype of endothelial cells. Conclusions Our data indicate a new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenesis. Moreover, we suggest the lncRNA H19 as a putative therapeutic target in hepatocellular carcinoma. Keywords: Exosomes, Long-non-coding RNA H19, CD90+ liver cancer cells, Angiogenesis
ArticleNumber	155
Audience	Academic
Author	Buccheri, Simona Conigliaro, Alice Tripodi, Marco Manno, Mauro Lo Dico, Alessia Dieli, Francesco Mancone, Carmine De Leo, Giacomo Costa, Viviana Raccosta, Samuele Alessandro, Riccardo Saieva, Laura
Author_xml	– sequence: 1 givenname: Alice surname: Conigliaro fullname: Conigliaro, Alice email: alice.conigliaro@uniroma1.it organization: Dipartimento di Biotecnologie Cellulari ed Ematologia, Sapienza University of Rome – sequence: 2 givenname: Viviana surname: Costa fullname: Costa, Viviana organization: Laboratory of Tissue Engineering - Innovative Technology Platforms for Tissue Engineering (PON01-00829), Rizzoli Orthopedic Institute – sequence: 3 givenname: Alessia surname: Lo Dico fullname: Lo Dico, Alessia organization: Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo – sequence: 4 givenname: Laura surname: Saieva fullname: Saieva, Laura organization: Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo – sequence: 5 givenname: Simona surname: Buccheri fullname: Buccheri, Simona organization: Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo, Servizio di Diabetologia, Dipartimento per la cura e lo studio della patologie addominali e dei trapianti addominali – sequence: 6 givenname: Francesco surname: Dieli fullname: Dieli, Francesco organization: Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo – sequence: 7 givenname: Mauro surname: Manno fullname: Manno, Mauro organization: Institute of Biophysics, National Research Council of Italy – sequence: 8 givenname: Samuele surname: Raccosta fullname: Raccosta, Samuele organization: Institute of Biophysics, National Research Council of Italy – sequence: 9 givenname: Carmine surname: Mancone fullname: Mancone, Carmine organization: Dipartimento di Biotecnologie Cellulari ed Ematologia, Sapienza University of Rome, National Institute for Infectious Diseases L. Spallanzani – sequence: 10 givenname: Marco surname: Tripodi fullname: Tripodi, Marco organization: National Institute for Infectious Diseases L. Spallanzani, Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Biotecnologie Cellulari ed Ematologia, Sapienza University of Rome – sequence: 11 givenname: Giacomo surname: De Leo fullname: De Leo, Giacomo organization: Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo – sequence: 12 givenname: Riccardo surname: Alessandro fullname: Alessandro, Riccardo email: riccardo.alessandro@unipa.it organization: Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo, Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council of Italy
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26272696$$D View this record in MEDLINE/PubMed
BookMark	eNp9ktuKFDEQhhtZcQ_6AN5IwBtBek3SOfWNMIyHFRYF0euQSVfPZEknY9K9zL69aWddZxeVXFRIff9fVKVOq6MQA1TVc4LPCVHiTSa0ZU2NCa8xo6LePapOCJOiZrxVRwf34-o05yuMiVSSPamOqaCSilacVGn5rsWvkXfXkJA1wc4BvM9oiN3kzQgIQhfHDXhn_K8U2m4gxPFmC2jcpDitNyUCSuDBZECxR7CLOQ6QkY1hNC64sEYXpEU-2K-fF0-rx73xGZ7dxrPq-4f335YX9eWXj5-Wi8vaCtyMddNJgJ53FmgjRU-t5BKMkSvBrCWtaOXK4I5arpiAjnd91ym74rRfSVDKyuaserv33U6rAYpPGJPxepvcYNKNjsbp-5ngNnodrzXjjVCYFINXtwYp_pggj3pweZ6ACRCnrInErOGU8xl9-QC9ilMKpb1CKSwYlbj5Q62NB-1CH0tdO5vqBWeEKdW2vFDnf6HK6WBwZaLQu_J-T_DisNG7Dn__cgHIHrAp5pygv0MI1vMm6f0m6bJJet4kvSsa-UBj3WhGF-dZOf9fJd0rc6kS1pAOZvFP0U8Nn93n
CitedBy_id	crossref_primary_10_1038_s41575_021_00508_3 crossref_primary_10_3389_fonc_2020_617837 crossref_primary_10_2147_IJN_S247210 crossref_primary_10_3892_mmr_2019_9856 crossref_primary_10_1186_s12964_022_00968_3 crossref_primary_10_1016_j_bbrc_2025_152257 crossref_primary_10_1038_s41420_022_00993_8 crossref_primary_10_1136_gutjnl_2019_318279 crossref_primary_10_1038_s41374_021_00723_1 crossref_primary_10_1038_s41417_020_00269_2 crossref_primary_10_1016_j_ijbiomac_2023_127061 crossref_primary_10_1177_0300060520934297 crossref_primary_10_3389_fimmu_2018_02270 crossref_primary_10_1002_jcb_27813 crossref_primary_10_1007_s10787_024_01487_y crossref_primary_10_1002_ctm2_70429 crossref_primary_10_1007_s00018_016_2346_3 crossref_primary_10_1016_j_talanta_2025_128095 crossref_primary_10_3390_cancers13112651 crossref_primary_10_1016_j_jhep_2021_12_005 crossref_primary_10_3390_cancers13040847 crossref_primary_10_1016_j_biopha_2018_03_148 crossref_primary_10_1097_MOL_0000000000000336 crossref_primary_10_1155_2019_9258075 crossref_primary_10_3390_cancers15010005 crossref_primary_10_1186_s12967_020_02426_5 crossref_primary_10_4251_wjgo_v15_i5_731 crossref_primary_10_3390_ijms19123742 crossref_primary_10_3390_ijms21155432 crossref_primary_10_1210_jc_2019_00536 crossref_primary_10_1016_j_suronc_2017_04_005 crossref_primary_10_1002_iub_2182 crossref_primary_10_1007_s12013_024_01423_5 crossref_primary_10_1016_j_canlet_2020_11_006 crossref_primary_10_3389_fonc_2019_00869 crossref_primary_10_1016_j_omtn_2023_07_009 crossref_primary_10_1016_j_prp_2024_155214 crossref_primary_10_1016_j_yexcr_2023_113621 crossref_primary_10_1038_s41392_021_00779_x crossref_primary_10_1016_j_omtn_2020_11_021 crossref_primary_10_1158_2326_6066_CIR_21_0258 crossref_primary_10_1186_s12964_018_0315_1 crossref_primary_10_1038_s41389_020_00274_y crossref_primary_10_1186_s12943_018_0831_z crossref_primary_10_3748_wjg_v25_i35_5283 crossref_primary_10_3390_diseases5010011 crossref_primary_10_1155_2021_3710372 crossref_primary_10_1186_s13045_019_0806_6 crossref_primary_10_34172_apb_2024_022 crossref_primary_10_3892_ijmm_2018_3383 crossref_primary_10_1016_j_phrs_2023_106880 crossref_primary_10_3390_cancers13010084 crossref_primary_10_1016_j_drup_2024_101084 crossref_primary_10_3389_fcell_2025_1485422 crossref_primary_10_1177_1533033818763450 crossref_primary_10_1186_s40902_022_00357_3 crossref_primary_10_3390_pharmaceutics15092365 crossref_primary_10_3390_toxics12070499 crossref_primary_10_1155_2019_1460572 crossref_primary_10_2217_fon_2017_0149 crossref_primary_10_1371_journal_pone_0256739 crossref_primary_10_3390_ijms221910572 crossref_primary_10_1007_s00253_021_11309_8 crossref_primary_10_1016_j_biopha_2023_115207 crossref_primary_10_3389_fcell_2021_751578 crossref_primary_10_1111_cas_14494 crossref_primary_10_3389_fcell_2023_1164301 crossref_primary_10_1186_s13287_018_0861_x crossref_primary_10_1016_j_omtn_2022_03_012 crossref_primary_10_1186_s12885_022_09666_2 crossref_primary_10_3390_cancers12103019 crossref_primary_10_3390_ijms22168527 crossref_primary_10_3390_cancers13123076 crossref_primary_10_1016_j_canlet_2018_01_001 crossref_primary_10_1007_s12015_018_9801_5 crossref_primary_10_1016_j_vph_2018_02_008 crossref_primary_10_1088_1748_605X_ad525c crossref_primary_10_1002_jcb_26521 crossref_primary_10_1038_s12276_022_00744_w crossref_primary_10_1186_s12943_018_0812_2 crossref_primary_10_1038_s41419_025_07956_8 crossref_primary_10_2174_0929867325666180821151409 crossref_primary_10_1016_j_canlet_2016_03_014 crossref_primary_10_1007_s12072_024_10722_1 crossref_primary_10_1038_s41392_024_01735_1 crossref_primary_10_1016_j_omtn_2020_09_039 crossref_primary_10_3389_fimmu_2022_997726 crossref_primary_10_1002_hep_30153 crossref_primary_10_1016_j_prp_2020_153261 crossref_primary_10_1002_mc_23782 crossref_primary_10_1038_s41392_021_00499_2 crossref_primary_10_1186_s13045_017_0426_y crossref_primary_10_1016_j_yexmp_2020_104472 crossref_primary_10_1016_j_bbadis_2019_01_015 crossref_primary_10_1002_ijc_32608 crossref_primary_10_1016_j_lfs_2019_116652 crossref_primary_10_1186_s12951_018_0429_z crossref_primary_10_2174_0929867327666200130103206 crossref_primary_10_3389_fphys_2018_00522 crossref_primary_10_1016_j_heliyon_2024_e29797 crossref_primary_10_1016_j_ygeno_2023_110703 crossref_primary_10_1007_s00441_023_03802_5 crossref_primary_10_1177_1933719119831775 crossref_primary_10_1016_j_omtn_2022_01_009 crossref_primary_10_3389_fonc_2022_1056379 crossref_primary_10_1016_j_bcp_2021_114730 crossref_primary_10_3389_fimmu_2024_1506561 crossref_primary_10_3390_cells7080093 crossref_primary_10_1007_s12094_017_1625_2 crossref_primary_10_2147_OTT_S281175 crossref_primary_10_3390_biology11050637 crossref_primary_10_1111_acel_13461 crossref_primary_10_1186_s12943_020_01199_1 crossref_primary_10_2478_cipms_2019_0034 crossref_primary_10_3389_fimmu_2020_565165 crossref_primary_10_3390_cells10113185 crossref_primary_10_3389_fonc_2022_895164 crossref_primary_10_3390_ijms23010008 crossref_primary_10_1038_s41417_024_00852_x crossref_primary_10_2147_JIR_S316414 crossref_primary_10_1016_j_lfs_2021_119177 crossref_primary_10_3390_cancers14143552 crossref_primary_10_1016_j_bioactmat_2021_08_029 crossref_primary_10_1016_j_bioactmat_2021_03_015 crossref_primary_10_3390_cells9122613 crossref_primary_10_1007_s13402_018_0378_4 crossref_primary_10_1002_JLB_3MIR0321_156R crossref_primary_10_1016_j_phrs_2021_105609 crossref_primary_10_3390_cells9091988 crossref_primary_10_1186_s12929_024_01055_0 crossref_primary_10_1002_ijc_31089 crossref_primary_10_1002_jev2_12271 crossref_primary_10_1016_j_colsurfb_2023_113704 crossref_primary_10_1016_j_ymthe_2023_05_003 crossref_primary_10_1016_j_vph_2020_106778 crossref_primary_10_3389_fcell_2021_643680 crossref_primary_10_1007_s12672_024_00879_4 crossref_primary_10_1155_2018_2747461 crossref_primary_10_3390_cells11060947 crossref_primary_10_2147_CIA_S288415 crossref_primary_10_1002_jcp_28374 crossref_primary_10_1002_kjm2_12318 crossref_primary_10_1155_2017_2931813 crossref_primary_10_3390_cancers15133298 crossref_primary_10_3389_fphar_2022_978151 crossref_primary_10_3389_fonc_2016_00125 crossref_primary_10_1111_jcmm_16359 crossref_primary_10_3390_molecules28093816 crossref_primary_10_3390_ijms21072286 crossref_primary_10_1016_j_canlet_2023_216089 crossref_primary_10_3390_ijms20225613 crossref_primary_10_3389_fcell_2021_625221 crossref_primary_10_1093_bib_bbz038 crossref_primary_10_1038_s41598_017_14356_2 crossref_primary_10_3389_fbioe_2022_1016833 crossref_primary_10_1016_j_cytogfr_2024_08_007 crossref_primary_10_3390_ijms21155250 crossref_primary_10_3892_or_2017_5742 crossref_primary_10_3390_cancers16142552 crossref_primary_10_4155_tde_2018_0051 crossref_primary_10_1016_j_bbcan_2020_188488 crossref_primary_10_1042_BCJ20160006 crossref_primary_10_1093_cvr_cvz139 crossref_primary_10_7554_eLife_78754 crossref_primary_10_1016_j_omto_2023_02_001 crossref_primary_10_1016_j_lfs_2021_119750 crossref_primary_10_1016_j_prp_2019_152468 crossref_primary_10_3389_fimmu_2024_1400112 crossref_primary_10_3389_fphar_2023_1110922 crossref_primary_10_1016_j_jconrel_2023_04_026 crossref_primary_10_1186_s13045_019_0739_0 crossref_primary_10_3390_ncrna6040042 crossref_primary_10_1177_0300985821999328 crossref_primary_10_3389_fonc_2023_1138142 crossref_primary_10_3390_biomedicines12081809 crossref_primary_10_3389_fphar_2018_00415 crossref_primary_10_2147_IJN_S327059 crossref_primary_10_1007_s00018_019_03215_0 crossref_primary_10_1016_j_bbagen_2020_129559 crossref_primary_10_1080_2162402X_2020_1779991 crossref_primary_10_3389_fphar_2020_00198 crossref_primary_10_3390_ncrna9020019 crossref_primary_10_1016_j_ygeno_2025_111043 crossref_primary_10_1097_HEP_0000000000001078 crossref_primary_10_1161_CIRCRESAHA_119_316337 crossref_primary_10_1038_s41571_018_0035_x crossref_primary_10_3892_ijo_2022_5336 crossref_primary_10_1016_j_critrevonc_2020_103111 crossref_primary_10_1111_hepr_12794 crossref_primary_10_1016_j_bbamcr_2023_119523 crossref_primary_10_5582_bst_2018_01181 crossref_primary_10_32604_or_2022_03536 crossref_primary_10_1002_j_2040_4603_2023_tb00263_x crossref_primary_10_1038_s41388_025_03412_1 crossref_primary_10_1155_2020_6786875 crossref_primary_10_1155_2018_8058979 crossref_primary_10_1093_cvr_cvz154 crossref_primary_10_3390_membranes12040352 crossref_primary_10_1002_cam4_1758 crossref_primary_10_1111_jcmm_13676 crossref_primary_10_3390_cancers9040038 crossref_primary_10_1016_j_biopha_2024_116424 crossref_primary_10_3389_fcell_2021_646864 crossref_primary_10_1007_s00018_019_03018_3 crossref_primary_10_1016_j_tranon_2023_101633 crossref_primary_10_1093_carcin_bgac066 crossref_primary_10_1007_s12032_025_02845_8 crossref_primary_10_3390_ijms20236016 crossref_primary_10_18632_oncotarget_10807 crossref_primary_10_1007_s00432_018_2712_7 crossref_primary_10_1016_j_omtn_2022_01_016 crossref_primary_10_1016_j_bcp_2022_115032 crossref_primary_10_1007_s12015_024_10797_1 crossref_primary_10_1016_j_canlet_2016_08_009 crossref_primary_10_3748_wjg_v24_i40_4519 crossref_primary_10_1186_s13578_019_0282_2 crossref_primary_10_3390_cells8040307 crossref_primary_10_1007_s12032_023_02101_x crossref_primary_10_1038_s41598_021_03688_9 crossref_primary_10_3390_ncrna3010010 crossref_primary_10_1177_15330338231184327 crossref_primary_10_1038_srep24141 crossref_primary_10_1016_j_canlet_2016_12_003 crossref_primary_10_1186_s12967_025_06878_5 crossref_primary_10_32604_or_2023_043481 crossref_primary_10_1111_cpr_12865 crossref_primary_10_2147_CMAR_S373165 crossref_primary_10_3390_cancers7040884 crossref_primary_10_1016_j_semcancer_2020_11_022 crossref_primary_10_1016_j_trsl_2020_11_010 crossref_primary_10_3390_cancers12020298 crossref_primary_10_1111_liv_14772 crossref_primary_10_3389_fonc_2021_653846 crossref_primary_10_3390_ijms26136333 crossref_primary_10_1016_j_ajpath_2016_07_011 crossref_primary_10_1016_j_mam_2017_11_001 crossref_primary_10_1002_pmic_201700103 crossref_primary_10_1186_s12943_018_0823_z crossref_primary_10_3389_fonc_2022_1014949 crossref_primary_10_1016_j_bios_2021_113176 crossref_primary_10_1016_j_heliyon_2023_e18626 crossref_primary_10_3390_cancers13061239 crossref_primary_10_1038_s41419_020_02810_5 crossref_primary_10_1002_biot_202100646 crossref_primary_10_1186_s40659_022_00397_z crossref_primary_10_1007_s12015_020_10114_6 crossref_primary_10_3390_ijms17122028 crossref_primary_10_3389_fcell_2021_691410 crossref_primary_10_1002_jcp_28785 crossref_primary_10_1007_s00018_019_03240_z crossref_primary_10_3389_fmolb_2023_1220193 crossref_primary_10_1016_j_tranon_2021_101134 crossref_primary_10_1186_s12943_019_1021_3 crossref_primary_10_1038_s41388_022_02197_x crossref_primary_10_1016_j_biochi_2023_03_014 crossref_primary_10_1016_j_yjmcc_2019_09_016 crossref_primary_10_3892_etm_2018_6059 crossref_primary_10_1038_srep45648 crossref_primary_10_3390_cancers11030378 crossref_primary_10_1038_s41388_024_03213_y crossref_primary_10_1038_s41419_023_06280_3 crossref_primary_10_1038_s41419_022_04848_z crossref_primary_10_1002_mco2_660 crossref_primary_10_3389_fonc_2022_884369 crossref_primary_10_1007_s10147_022_02129_5 crossref_primary_10_1016_j_omtn_2020_05_028 crossref_primary_10_1186_s13046_023_02619_y crossref_primary_10_1186_s12943_017_0714_8 crossref_primary_10_1186_s12943_018_0880_3 crossref_primary_10_1038_s41417_023_00679_y crossref_primary_10_3389_fgene_2020_567200 crossref_primary_10_1080_21655979_2021_1886771 crossref_primary_10_3390_ijms23052490 crossref_primary_10_1093_carcin_bgae030 crossref_primary_10_1016_j_canlet_2020_12_005 crossref_primary_10_1155_2021_2550399 crossref_primary_10_15252_embj_2021109288 crossref_primary_10_1038_s41598_023_27982_w crossref_primary_10_1016_j_canlet_2020_06_006 crossref_primary_10_1016_j_gene_2019_144044 crossref_primary_10_3892_ijo_2022_5381 crossref_primary_10_1177_1756284818821560 crossref_primary_10_3390_cancers15010286 crossref_primary_10_3390_jcm8071033 crossref_primary_10_1002_iub_2141 crossref_primary_10_3390_pharmaceutics12121135 crossref_primary_10_1016_j_canlet_2020_02_003 crossref_primary_10_3390_ncrna10010012 crossref_primary_10_3389_fcell_2021_791882 crossref_primary_10_3390_cancers14010020 crossref_primary_10_3390_jcm8010026 crossref_primary_10_3389_fimmu_2020_00940 crossref_primary_10_1007_s00253_019_09837_5 crossref_primary_10_3390_biomedicines13020353 crossref_primary_10_3892_mmr_2019_10340 crossref_primary_10_1007_s12032_023_02125_3 crossref_primary_10_1113_JP283074 crossref_primary_10_1016_j_addr_2021_05_026 crossref_primary_10_1007_s40259_019_00338_5 crossref_primary_10_1016_j_ajpath_2022_06_007 crossref_primary_10_1016_j_omtn_2022_05_034 crossref_primary_10_3389_fonc_2019_00739 crossref_primary_10_3390_diagnostics15131655 crossref_primary_10_1186_s12935_022_02643_6 crossref_primary_10_1186_s12964_020_00643_5 crossref_primary_10_3390_biology12010110 crossref_primary_10_1080_15384047_2024_2321768 crossref_primary_10_1186_s12943_024_01979_z crossref_primary_10_5812_hepatmon_58021 crossref_primary_10_1038_s41392_020_00430_1 crossref_primary_10_3390_biom13010003 crossref_primary_10_1080_14728222_2018_1464141 crossref_primary_10_1007_s12015_022_10358_4 crossref_primary_10_1186_s13045_017_0428_9 crossref_primary_10_1111_jcmm_12950 crossref_primary_10_3350_cmh_2021_0390 crossref_primary_10_3389_fcell_2022_830208 crossref_primary_10_1155_2022_9356807 crossref_primary_10_1016_j_semcancer_2021_03_020 crossref_primary_10_1038_s41598_020_57497_7 crossref_primary_10_1016_j_lfs_2020_118725 crossref_primary_10_1016_j_ejpsy_2017_10_002 crossref_primary_10_1038_s41388_018_0146_y crossref_primary_10_1111_cpr_12541 crossref_primary_10_1155_2022_5544276 crossref_primary_10_1007_s11684_023_1049_z
Cites_doi	10.1371/journal.pone.0000845 10.1172/JCI118543 10.1111/j.1742-4658.2012.08694.x 10.1038/35013106 10.1371/journal.pone.0076830 10.1016/j.molcel.2013.08.027 10.1002/hep.26168 10.1159/000343863 10.1038/ng0492-40 10.1007/s13277-014-2185-5 10.1007/s00109-013-1020-6 10.1002/pmic.201200398 10.1007/s13277-013-1561-x 10.1016/j.yexmp.2010.05.005 10.1016/j.ccr.2008.01.013 10.5009/gnl.2012.6.1.29 10.1016/j.bbamcr.2006.08.008 10.1016/j.canlet.2015.02.035 10.3748/wjg.v20.i8.2098 10.1007/s11596-013-1078-y 10.1016/S0140-6736(11)61347-0 10.1634/stemcells.2006-0114 10.1111/j.1440-1746.2010.06341.x 10.1002/hep.22082 10.1053/jhep.2000.20349 10.1016/j.fob.2014.04.007 10.1038/cdd.2014.130 10.1002/ijc.26217 10.1016/j.canlet.2013.01.033 10.1016/j.canlet.2014.03.009 10.1101/gad.234419.113 10.3390/ijms151120434 10.2478/v10019-012-0025-z 10.1136/jcp.2004.023648 10.1016/j.stem.2010.11.010 10.1002/cncr.25960 10.1016/j.bbamcr.2014.03.023 10.1016/j.semcdb.2015.01.013 10.1016/j.acthis.2011.01.001 10.3892/mco.2014.429 10.1002/hep.21227 10.1093/nar/gks296 10.1177/1947601913499020 10.1371/journal.pone.0032444 10.1172/JCI116967 10.1371/journal.pone.0110744 10.1055/s-0034-1397350 10.1007/s10620-010-1256-8 10.4161/cbt.8.18.9843 10.1242/jcs.141069 10.1002/0471143030.cb0322s30
ContentType	Journal Article
Copyright	Conigliaro et al. 2015 COPYRIGHT 2015 BioMed Central Ltd. Copyright BioMed Central 2015
Copyright_xml	– notice: Conigliaro et al. 2015 – notice: COPYRIGHT 2015 BioMed Central Ltd. – notice: Copyright BioMed Central 2015
DBID	C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TO 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 5PM
DOI	10.1186/s12943-015-0426-x
DatabaseName	Springer Nature OA Free Journals CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE Publicly Available Content Database MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: ProQuest Publicly Available Content url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Biology
EISSN	1476-4598
EndPage	155
ExternalDocumentID	PMC4536801 4020629151 A541488995 26272696 10_1186_s12943_015_0426_x
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	United Kingdom
GeographicLocations_xml	– name: United Kingdom
GrantInformation_xml	– fundername: AIRC Associazione Italiana per la Ricerca sul Cancro grantid: ID0ED6AE976 – fundername: MIUR Ministero dell’Universita e Ricerca Scientifica grantid: ID0EZ1AE975
GroupedDBID	--- 0R~ 123 29M 2WC 4.4 53G 5VS 7X7 88E 8FI 8FJ AAFWJ AAJSJ AASML ABDBF ABUWG ACGFO ACGFS ACIHN ACIWK ACMJI ACPRK ACUHS ADBBV ADRAZ ADUKV AEAQA AENEX AFKRA AFPKN AFRAH AHBYD AHMBA AHSBF AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AMTXH AOIJS BAPOH BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU CS3 DIK DU5 E3Z EAD EAP EAS EBD EBLON EBS EJD EMB EMK EMOBN ESX F5P FYUFA GROUPED_DOAJ GX1 H13 HH5 HMCUK HYE IAO IHR INH INR ITC KQ8 M1P M48 M~E O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PUEGO PZZ RBZ RNS ROL RPM RSV SBL SOJ SV3 TR2 TUS UKHRP W2D WOQ WOW XSB AAYXX AFFHD CITATION ALIPV CGR CUY CVF ECM EIF NPM 3V. 7TO 7XB 8FK AZQEC DWQXO H94 K9. PKEHL PQEST PQUKI PRINS 7X8 5PM
ID	FETCH-LOGICAL-c603t-3d7eef5dce2376f2c757eaa7b64cc19697ba0d2c5846ed5dfdd8cb52fb7e88c73
IEDL.DBID	PIMPY
ISICitedReferencesCount	398
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000359476100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1476-4598
IngestDate	Tue Nov 04 01:52:02 EST 2025 Sun Nov 09 12:24:53 EST 2025 Sun Oct 19 01:27:16 EDT 2025 Tue Nov 11 10:57:09 EST 2025 Tue Nov 04 18:24:23 EST 2025 Mon Jul 21 05:39:46 EDT 2025 Tue Nov 18 22:14:39 EST 2025 Sat Nov 29 02:12:57 EST 2025 Sat Sep 06 07:32:26 EDT 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	1
Keywords	CD90+ liver cancer cells Angiogenesis Long-non-coding RNA H19 Exosomes
Language	English
License	Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c603t-3d7eef5dce2376f2c757eaa7b64cc19697ba0d2c5846ed5dfdd8cb52fb7e88c73
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
OpenAccessLink	https://www.proquest.com/publiccontent/docview/1780642703?pq-origsite=%requestingapplication%
PMID	26272696
PQID	1780642703
PQPubID	42702
PageCount	1
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_4536801 proquest_miscellaneous_1704352551 proquest_journals_1780642703 gale_infotracmisc_A541488995 gale_infotracacademiconefile_A541488995 pubmed_primary_26272696 crossref_primary_10_1186_s12943_015_0426_x crossref_citationtrail_10_1186_s12943_015_0426_x springer_journals_10_1186_s12943_015_0426_x
PublicationCentury	2000
PublicationDate	2015-08-14
PublicationDateYYYYMMDD	2015-08-14
PublicationDate_xml	– month: 08 year: 2015 text: 2015-08-14 day: 14
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationTitle	Molecular cancer
PublicationTitleAbbrev	Mol Cancer
PublicationTitleAlternate	Mol Cancer
PublicationYear	2015
Publisher	BioMed Central BioMed Central Ltd Springer Nature B.V
Publisher_xml	– name: BioMed Central – name: BioMed Central Ltd – name: Springer Nature B.V
References	JR Eun (426_CR29) 2014; 9 R Noto (426_CR52) 2012; 7 BK Dey (426_CR44) 2014; 28 DK Kim (426_CR50) 1994; 93 S Ma (426_CR10) 2010; 7 Y Fellig (426_CR49) 2005; 58 JW Lu (426_CR18) 2011; 113 Y Zhang (426_CR42) 1992; 1 ZF Yang (426_CR11) 2008; 13 AN Kallen (426_CR45) 2013; 52 IJ Matouk (426_CR48) 2007; 2 Z Yao (426_CR8) 2009; 8 TA Rege (426_CR13) 2006; 1763 T Yamashita (426_CR12) 2013; 57 ZF Yang (426_CR19) 2008; 47 J George (426_CR34) 2015; 35 C Braicu (426_CR24) 2015; 22 Z Guo (426_CR20) 2014; 20 K Takahashi (426_CR37) 2014; 4 J Ye (426_CR38) 2014; 35 IJ Matouk (426_CR36) 2014; 1843 T Kogure (426_CR25) 2013; 4 426_CR33 C Corrado (426_CR27) 2014; 348 K Uchino (426_CR2) 2011; 117 SK Yoon (426_CR7) 2012; 6 YF Pan (426_CR32) 2013; 33 S Lingala (426_CR16) 2010; 89 DK Han (426_CR51) 1996; 97 XH Yu (426_CR17) 2011; 56 L Fang (426_CR21) 2012; 46 F Yang (426_CR46) 2012; 279 J Webber (426_CR28) 2015; 40 DJ Yoo (426_CR3) 2011; 26 AT Hark (426_CR43) 2000; 405 FJ Yu (426_CR30) 2015; 3 J Sun (426_CR31) 2014; 15 C Ma (426_CR35) 2014; 35 426_CR23 S Fontana (426_CR22) 2013; 13 VA Moran (426_CR41) 2012; 40 M Luo (426_CR47) 2013; 333 C Kahlert (426_CR39) 2013; 91 MB Herrera (426_CR14) 2006; 24 N Oishi (426_CR6) 2014; 3 CH Sukowati (426_CR15) 2013; 8 S Taverna (426_CR26) 2012; 130 A Forner (426_CR1) 2012; 379 A Suzuki (426_CR5) 2000; 32 K Takahashi (426_CR40) 2014; 127 M Roncalli (426_CR4) 2010; 42 T Chiba (426_CR9) 2006; 44 23401131 - Proteomics. 2013 May;13(10-11):1581-94 10839547 - Nature. 2000 May 25;405(6785):486-9 16799977 - Hepatology. 2006 Jul;44(1):240-51 25387074 - Int J Mol Sci. 2014;15(11):20434-48 24055342 - Mol Cell. 2013 Oct 10;52(1):101-12 21437884 - Cancer. 2011 Oct 1;117(19):4475-83 20437099 - Dig Dis Sci. 2011 Jan;56(1):252-9 22492512 - Nucleic Acids Res. 2012 Aug;40(14):6391-400 25632936 - Semin Liver Dis. 2015 Feb;35(1):63-74 16189152 - J Clin Pathol. 2005 Oct;58(10):1064-8 20511115 - Exp Mol Pathol. 2010 Aug;89(1):27-35 24420150 - Tumour Biol. 2014 May;35(5):3945-51 23077462 - Radiol Oncol. 2012 Sep;46(3):233-41 18242515 - Cancer Cell. 2008 Feb;13(2):153-66 24616575 - World J Gastroenterol. 2014 Feb 28;20(8):2098-106 24532688 - Genes Dev. 2014 Mar 1;28(5):491-501 22776265 - FEBS J. 2012 Sep;279(17):3159-65 24167654 - Genes Cancer. 2013 Jul;4(7-8):261-72 23174907 - Hepatology. 2013 Apr;57(4):1484-97 24657661 - Cancer Lett. 2014 Jun 28;348(1-2):71-6 21112564 - Cell Stem Cell. 2010 Dec 3;7(6):694-707 22353262 - Lancet. 2012 Mar 31;379(9822):1245-55 21175808 - J Gastroenterol Hepatol. 2011 Jan;26(1):145-54 23392715 - J Huazhong Univ Sci Technolog Med Sci. 2013 Feb;33(1):96-101 18275073 - Hepatology. 2008 Mar;47(3):919-28 25662446 - Semin Cell Dev Biol. 2015 Apr;40:27-34 24703882 - Biochim Biophys Acta. 2014 Jul;1843(7):1414-26 24116172 - PLoS One. 2013;8(10):e76830 23519402 - J Mol Med (Berl). 2013 Apr;91(4):431-7 20547308 - Dig Liver Dis. 2010 Jul;42 Suppl 3:S228-34 8282806 - J Clin Invest. 1994 Jan;93(1):355-60 21272924 - Acta Histochem. 2011 Dec;113(8):833-8 17786216 - PLoS One. 2007;2(9):e845 22412873 - PLoS One. 2012;7(3):e32444 21630268 - Int J Cancer. 2012 May 1;130(9):2033-43 25338121 - PLoS One. 2014;9(10):e110744 16945998 - Stem Cells. 2006 Dec;24(12):2840-50 11093729 - Hepatology. 2000 Dec;32(6):1230-9 23354591 - Cancer Lett. 2013 Jun 10;333(2):213-21 24918061 - FEBS Open Bio. 2014 May 09;4:458-67 19901516 - Cancer Biol Ther. 2009 Sep;8(18):1691-8 25469263 - Mol Clin Oncol. 2015 Jan;3(1):13-17 24463816 - J Cell Sci. 2014 Apr 1;127(Pt 7):1585-94 24944998 - Liver Cancer. 2014 May;3(2):71-84 1363808 - Nat Genet. 1992 Apr;1(1):40-4 25721084 - Cancer Lett. 2015 May 1;360(2):119-24 16996153 - Biochim Biophys Acta. 2006 Oct;1763(10):991-9 22375168 - Gut Liver. 2012 Jan;6(1):29-40 24920070 - Tumour Biol. 2014 Sep;35(9):9163-9 8636440 - J Clin Invest. 1996 Mar 1;97(5):1276-85 18228490 - Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22 25236394 - Cell Death Differ. 2015 Jan;22(1):34-45
References_xml	– volume: 2 start-page: e845 issue: 9 year: 2007 ident: 426_CR48 publication-title: PLoS One doi: 10.1371/journal.pone.0000845 – volume: 97 start-page: 1276 issue: 5 year: 1996 ident: 426_CR51 publication-title: J Clin Invest doi: 10.1172/JCI118543 – volume: 279 start-page: 3159 issue: 17 year: 2012 ident: 426_CR46 publication-title: FEBS J doi: 10.1111/j.1742-4658.2012.08694.x – volume: 405 start-page: 486 issue: 6785 year: 2000 ident: 426_CR43 publication-title: Nature doi: 10.1038/35013106 – volume: 8 start-page: e76830 issue: 10 year: 2013 ident: 426_CR15 publication-title: PLoS One doi: 10.1371/journal.pone.0076830 – volume: 52 start-page: 101 issue: 1 year: 2013 ident: 426_CR45 publication-title: Mol Cell doi: 10.1016/j.molcel.2013.08.027 – volume: 57 start-page: 1484 issue: 4 year: 2013 ident: 426_CR12 publication-title: Hepatology doi: 10.1002/hep.26168 – volume: 3 start-page: 71 issue: 2 year: 2014 ident: 426_CR6 publication-title: Liver Cancer doi: 10.1159/000343863 – volume: 1 start-page: 40 issue: 1 year: 1992 ident: 426_CR42 publication-title: Nat Genet doi: 10.1038/ng0492-40 – volume: 35 start-page: 9163 issue: 9 year: 2014 ident: 426_CR35 publication-title: J Int Soc Oncodev Biol Med doi: 10.1007/s13277-014-2185-5 – volume: 91 start-page: 431 issue: 4 year: 2013 ident: 426_CR39 publication-title: J Mol Med (Berl) doi: 10.1007/s00109-013-1020-6 – volume: 13 start-page: 1581 issue: 10-11 year: 2013 ident: 426_CR22 publication-title: Proteomics doi: 10.1002/pmic.201200398 – volume: 35 start-page: 3945 issue: 5 year: 2014 ident: 426_CR38 publication-title: J Int Soc Oncodev Biol Med doi: 10.1007/s13277-013-1561-x – volume: 89 start-page: 27 issue: 1 year: 2010 ident: 426_CR16 publication-title: Exp Mol Pathol doi: 10.1016/j.yexmp.2010.05.005 – volume: 13 start-page: 153 issue: 2 year: 2008 ident: 426_CR11 publication-title: Cancer Cell doi: 10.1016/j.ccr.2008.01.013 – volume: 6 start-page: 29 issue: 1 year: 2012 ident: 426_CR7 publication-title: Gut Liver doi: 10.5009/gnl.2012.6.1.29 – volume: 1763 start-page: 991 issue: 10 year: 2006 ident: 426_CR13 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2006.08.008 – ident: 426_CR33 doi: 10.1016/j.canlet.2015.02.035 – volume: 20 start-page: 2098 issue: 8 year: 2014 ident: 426_CR20 publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i8.2098 – volume: 33 start-page: 96 issue: 1 year: 2013 ident: 426_CR32 publication-title: J Huazhong Univ Sci Technol Med sci Hua zhong ke ji da xue xue bao Yi xue Ying De wen ban = Huazhong keji daxue xuebao Yixue Yingdewen ban doi: 10.1007/s11596-013-1078-y – volume: 379 start-page: 1245 issue: 9822 year: 2012 ident: 426_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(11)61347-0 – volume: 24 start-page: 2840 issue: 12 year: 2006 ident: 426_CR14 publication-title: Stem Cells doi: 10.1634/stemcells.2006-0114 – volume: 26 start-page: 145 issue: 1 year: 2011 ident: 426_CR3 publication-title: J Gastroenterol Hepatol doi: 10.1111/j.1440-1746.2010.06341.x – volume: 47 start-page: 919 issue: 3 year: 2008 ident: 426_CR19 publication-title: Hepatology doi: 10.1002/hep.22082 – volume: 32 start-page: 1230 issue: 6 year: 2000 ident: 426_CR5 publication-title: Hepatology doi: 10.1053/jhep.2000.20349 – volume: 4 start-page: 458 year: 2014 ident: 426_CR37 publication-title: FEBS open Bio doi: 10.1016/j.fob.2014.04.007 – volume: 22 start-page: 34 issue: 1 year: 2015 ident: 426_CR24 publication-title: Cell Death Differ doi: 10.1038/cdd.2014.130 – volume: 130 start-page: 2033 issue: 9 year: 2012 ident: 426_CR26 publication-title: Int J Cancer doi: 10.1002/ijc.26217 – volume: 333 start-page: 213 issue: 2 year: 2013 ident: 426_CR47 publication-title: Cancer Lett doi: 10.1016/j.canlet.2013.01.033 – volume: 348 start-page: 71 issue: 1-2 year: 2014 ident: 426_CR27 publication-title: Cancer Lett doi: 10.1016/j.canlet.2014.03.009 – volume: 28 start-page: 491 issue: 5 year: 2014 ident: 426_CR44 publication-title: Genes Dev doi: 10.1101/gad.234419.113 – volume: 15 start-page: 20434 issue: 11 year: 2014 ident: 426_CR31 publication-title: Int J Mol Sci doi: 10.3390/ijms151120434 – volume: 46 start-page: 233 issue: 3 year: 2012 ident: 426_CR21 publication-title: Radiol Oncol doi: 10.2478/v10019-012-0025-z – volume: 58 start-page: 1064 issue: 10 year: 2005 ident: 426_CR49 publication-title: J Clin Pathol doi: 10.1136/jcp.2004.023648 – volume: 7 start-page: 694 issue: 6 year: 2010 ident: 426_CR10 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.11.010 – volume: 42 start-page: S228 issue: Suppl 3 year: 2010 ident: 426_CR4 publication-title: Off J Italian Soc Gastroenterol Italian Assoc Study Liver – volume: 117 start-page: 4475 issue: 19 year: 2011 ident: 426_CR2 publication-title: Cancer doi: 10.1002/cncr.25960 – volume: 1843 start-page: 1414 issue: 7 year: 2014 ident: 426_CR36 publication-title: Biochim Biophys Acta doi: 10.1016/j.bbamcr.2014.03.023 – volume: 40 start-page: 27 year: 2015 ident: 426_CR28 publication-title: Semin Cell Dev Biol doi: 10.1016/j.semcdb.2015.01.013 – volume: 113 start-page: 833 issue: 8 year: 2011 ident: 426_CR18 publication-title: Acta Histochem doi: 10.1016/j.acthis.2011.01.001 – volume: 3 start-page: 13 issue: 1 year: 2015 ident: 426_CR30 publication-title: Mol Clin Oncol doi: 10.3892/mco.2014.429 – volume: 44 start-page: 240 issue: 1 year: 2006 ident: 426_CR9 publication-title: Hepatology doi: 10.1002/hep.21227 – volume: 40 start-page: 6391 issue: 14 year: 2012 ident: 426_CR41 publication-title: Nucleic Acids Res doi: 10.1093/nar/gks296 – volume: 4 start-page: 261 issue: 7-8 year: 2013 ident: 426_CR25 publication-title: Genes Cancer doi: 10.1177/1947601913499020 – volume: 7 start-page: e32444 issue: 3 year: 2012 ident: 426_CR52 publication-title: PLoS One doi: 10.1371/journal.pone.0032444 – volume: 93 start-page: 355 issue: 1 year: 1994 ident: 426_CR50 publication-title: J Clin Invest doi: 10.1172/JCI116967 – volume: 9 start-page: e110744 issue: 10 year: 2014 ident: 426_CR29 publication-title: PLoS One doi: 10.1371/journal.pone.0110744 – volume: 35 start-page: 63 issue: 1 year: 2015 ident: 426_CR34 publication-title: Semin Liver Dis doi: 10.1055/s-0034-1397350 – volume: 56 start-page: 252 issue: 1 year: 2011 ident: 426_CR17 publication-title: Dig Dis Sci doi: 10.1007/s10620-010-1256-8 – volume: 8 start-page: 1691 issue: 18 year: 2009 ident: 426_CR8 publication-title: Cancer Biol Therapy doi: 10.4161/cbt.8.18.9843 – volume: 127 start-page: 1585 issue: Pt 7 year: 2014 ident: 426_CR40 publication-title: J Cell Sci doi: 10.1242/jcs.141069 – ident: 426_CR23 doi: 10.1002/0471143030.cb0322s30 – reference: 23354591 - Cancer Lett. 2013 Jun 10;333(2):213-21 – reference: 17786216 - PLoS One. 2007;2(9):e845 – reference: 25721084 - Cancer Lett. 2015 May 1;360(2):119-24 – reference: 11093729 - Hepatology. 2000 Dec;32(6):1230-9 – reference: 21437884 - Cancer. 2011 Oct 1;117(19):4475-83 – reference: 1363808 - Nat Genet. 1992 Apr;1(1):40-4 – reference: 24944998 - Liver Cancer. 2014 May;3(2):71-84 – reference: 22375168 - Gut Liver. 2012 Jan;6(1):29-40 – reference: 24657661 - Cancer Lett. 2014 Jun 28;348(1-2):71-6 – reference: 18275073 - Hepatology. 2008 Mar;47(3):919-28 – reference: 23519402 - J Mol Med (Berl). 2013 Apr;91(4):431-7 – reference: 16799977 - Hepatology. 2006 Jul;44(1):240-51 – reference: 22412873 - PLoS One. 2012;7(3):e32444 – reference: 24055342 - Mol Cell. 2013 Oct 10;52(1):101-12 – reference: 21272924 - Acta Histochem. 2011 Dec;113(8):833-8 – reference: 8636440 - J Clin Invest. 1996 Mar 1;97(5):1276-85 – reference: 24703882 - Biochim Biophys Acta. 2014 Jul;1843(7):1414-26 – reference: 10839547 - Nature. 2000 May 25;405(6785):486-9 – reference: 20511115 - Exp Mol Pathol. 2010 Aug;89(1):27-35 – reference: 16945998 - Stem Cells. 2006 Dec;24(12):2840-50 – reference: 25632936 - Semin Liver Dis. 2015 Feb;35(1):63-74 – reference: 23174907 - Hepatology. 2013 Apr;57(4):1484-97 – reference: 21630268 - Int J Cancer. 2012 May 1;130(9):2033-43 – reference: 20437099 - Dig Dis Sci. 2011 Jan;56(1):252-9 – reference: 24918061 - FEBS Open Bio. 2014 May 09;4:458-67 – reference: 23401131 - Proteomics. 2013 May;13(10-11):1581-94 – reference: 22776265 - FEBS J. 2012 Sep;279(17):3159-65 – reference: 24116172 - PLoS One. 2013;8(10):e76830 – reference: 18228490 - Curr Protoc Cell Biol. 2006 Apr;Chapter 3:Unit 3.22 – reference: 19901516 - Cancer Biol Ther. 2009 Sep;8(18):1691-8 – reference: 24532688 - Genes Dev. 2014 Mar 1;28(5):491-501 – reference: 22353262 - Lancet. 2012 Mar 31;379(9822):1245-55 – reference: 25338121 - PLoS One. 2014;9(10):e110744 – reference: 8282806 - J Clin Invest. 1994 Jan;93(1):355-60 – reference: 18242515 - Cancer Cell. 2008 Feb;13(2):153-66 – reference: 24463816 - J Cell Sci. 2014 Apr 1;127(Pt 7):1585-94 – reference: 24616575 - World J Gastroenterol. 2014 Feb 28;20(8):2098-106 – reference: 24920070 - Tumour Biol. 2014 Sep;35(9):9163-9 – reference: 25387074 - Int J Mol Sci. 2014;15(11):20434-48 – reference: 21175808 - J Gastroenterol Hepatol. 2011 Jan;26(1):145-54 – reference: 25236394 - Cell Death Differ. 2015 Jan;22(1):34-45 – reference: 16996153 - Biochim Biophys Acta. 2006 Oct;1763(10):991-9 – reference: 20547308 - Dig Liver Dis. 2010 Jul;42 Suppl 3:S228-34 – reference: 25662446 - Semin Cell Dev Biol. 2015 Apr;40:27-34 – reference: 22492512 - Nucleic Acids Res. 2012 Aug;40(14):6391-400 – reference: 23077462 - Radiol Oncol. 2012 Sep;46(3):233-41 – reference: 24167654 - Genes Cancer. 2013 Jul;4(7-8):261-72 – reference: 25469263 - Mol Clin Oncol. 2015 Jan;3(1):13-17 – reference: 23392715 - J Huazhong Univ Sci Technolog Med Sci. 2013 Feb;33(1):96-101 – reference: 21112564 - Cell Stem Cell. 2010 Dec 3;7(6):694-707 – reference: 24420150 - Tumour Biol. 2014 May;35(5):3945-51 – reference: 16189152 - J Clin Pathol. 2005 Oct;58(10):1064-8
SSID	ssj0017874
Score	2.6012418
Snippet	Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in... CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in vitro... Background CD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in... BACKGROUNDCD90+ liver cancer cells have been described as cancer stem-cell-like (CSC), displaying aggressive and metastatic phenotype. Using two different in...
SourceID	pubmedcentral proquest gale pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	155
SubjectTerms	Analysis Biomedical and Life Sciences Biomedicine Cancer cells Cancer Research Cell Adhesion Cell Line, Tumor Development and progression Endothelial Cells - metabolism Endothelium Exosomes - metabolism Genetic aspects Human Umbilical Vein Endothelial Cells - metabolism Humans Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Metastasis Oncology Phenotype Physiological aspects RNA RNA, Long Noncoding - genetics Thy-1 Antigens - metabolism
SummonAdditionalLinks	– databaseName: SpringerLINK Contemporary 1997-Present dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ba9VAEB6kXvDFS71Fq6wgCJbFnE32ksdDtfRBD1K19G1JdjdYSBM5OZX6753Jjeaggr4kDzsbltlvdmYzN4BXsTe6jEPChSw9T03muVF5zIMrXCLxqbqyiycf9GplTk-zT0MedztGu48uye6k7sTaqLctaqaUYn8kJ7ufo-F4HbWdIWk8_nwyuQ4QgengvvzttJkC2j6Gr-ih7RjJLUdpp38O7_7Xyu_BncHcZMseH_fhWqh34WbfgPLnLtz6OLjWH8D64F0W77OK4jSYIyzgK1RVy84bTz2-Agu1p3ytCiHbDTGKD2voJy4b2v3gOzBqw4K6kTUlC5dN25yHllFEfN-Lgh0tMlbV7ni1fAhfD99_OTjiQ0MG7lScbHjidQilRJ5QLE0pnJY65LkuVOoc1dnRRR574cioCV760nvjCinKQgdjnE4ewU7d1OEJMMqHlYnAqUamwuV4jGi8XblFKbLYFWkE8bhL1g3VyqlpRmW7W4tRtueqRa5a4qq9jODNNOV7X6rjb8SvaestiTF-1-VDNgKujgpi2SW1Rzd4GZUR7M0oUfzcfHgEjx3Ev7UIQrrY4WkawctpmGZSSFsdmguiiVOqRSsXETzusTYtWyihhcpUBHqGwomAioLPR-qzb11x8FQmCq2OCPZHLF5Z1p-48fSfqJ_BbdGB2fBFugc7m_VFeA433I_NWbt-0UnjL0ArMkA priority: 102 providerName: Springer Nature
Title	CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
URI	https://link.springer.com/article/10.1186/s12943-015-0426-x https://www.ncbi.nlm.nih.gov/pubmed/26272696 https://www.proquest.com/docview/1780642703 https://www.proquest.com/docview/1704352551 https://pubmed.ncbi.nlm.nih.gov/PMC4536801
Volume	14
WOSCitedRecordID	wos000359476100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVADU databaseName: BioMedCentral customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: RBZ dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals - NZ customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: DOA dateStart: 20020101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: M~E dateStart: 20020101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: BENPR dateStart: 20090101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: 7X7 dateStart: 20090101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: PIMPY dateStart: 20090101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: Springer Journals New Starts & Take-Overs Collection customDbUrl: eissn: 1476-4598 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0017874 issn: 1476-4598 databaseCode: RSV dateStart: 20021201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3fb9MwED6xFhAv_BgwAqMyEhISk9XEiWPnCZWxaUisqgpM5SlKbEdMypKt6VD57_ElblkrsSdeEkW2Iyd3vrN95-8DeOtrKQrfhJTxQtNIJprKOPOpUbkKub3GLezi2RcxHsvZLJm449GNS6tc2cTWUHdoz5i3bY3wUNcKd8yHgZA4c7bq-uHyiiKHFMZaHaHGDvQReEv2oD_5fDr5sY4qWOWMXGQzkPGwsb4uwmwiTnElQZcbvmnbQt9wUdvpk1sx1NY1HT_6vx_1GB66KSoZdTr1BO6YahfudaSVv3fh_qkLxz-F-eGnxD8gJeZ2EIX6Y2-mLBtyUWvkBTPEVBrPeJVWzdsigjllNW78EkcRZO-GIHWL9aekLohZ1k19YRqCHe_4K8hJkJCyUtPx6Bl8Pz76dnhCHYkDVbEfLmiohTEFtz8L828KpgQXJstEHkdKITaPyDNfM4UTIaO5LrSWKuesyIWRUonwOfSqujIvgOAZWh4y21TyiKnMmh5hV2QqKFjiqzzywF-JL1UO4RyJNsq0XenIOO0knlqJpyjxdOnB-3WTyw7e47bK71AnUhz69r0qcycYbO8QRCsdIaW6tAtY7sH-Rk07ZNVm8UodUmcymvSv9D14sy7GlpgGV5n6Guv4EeLX8sCDvU4J191mMRMsTmIPxIZ6risgkPhmSXX-swUUj3gY25mKBwcrRb7RrX_9jZe3f8QreMDakSVpEO1DbzG_Nq_hrvq1OG_mA9gRM9Fe5QD6H4_Gk-mg3Q4ZuDFrn6Zfz_4AXCROXg
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6V8rzwKK9AASOBkKisJk4cOweEVi3VVm1XCJVqbyaxHVEpTcpmC9s_xW_Ek8fSXYneeuCSHGxHTvLNjMeemQ_gjW-kyH0bUsZzQyOZGCrj1KdWZzrk7ho3ZReP9sVoJMfj5PMK_O5zYTCssteJjaI2lcY98s1ASFwrO4B-PP1BkTUKT1d7Co0WFnv2_Jdz2eoPu9vu_75lbOfT4daQdqwCVMd-OKWhEdbm3GiLASE504ILm6YiiyOtsViMyFLfMI2W2RpucmOkzjjLM2Gl1CJ0z70G150eFxhCJsZzB89NUUTdyWkg483a2dIIo5U4RU-FzhZs37IFuGACl8Mzl85oG9O3c-9_-2j34W63yCaDVioewIot1-BmS7t5vga3DrqAgocw2dpO_A1SYHQK0SgB7maLoiYnlUFmM0tsaTBLrXCC2jQRjIqrcOuadCRH7m4Jks-4FQGpcmJnVV2d2JpgHkDLwEGGQUKKUn8ZDR7B1yt598ewWlalfQoEs4B5yNxQySOmU6c8hfMpdZCzxNdZ5IHfA0TprkY7UoUUqvHVZKxaTCmHKYWYUjMP3s-HnLYFSi7r_A5Rp1B5uefqtMvBcLPDMmBqgKTw0rng3IP1hZ5O6ejF5h5wqlN6tfqLNg9ez5txJAbylbY6wz5-hBV4eeDBkxbm82mzmAkWJ7EHYkEA5h2wFPpiS3n8vSmJHvEwdmstDzZ6UbkwrX99jWeXv8QruD08PNhX-7ujvedwhzVyLGkQrcPqdHJmX8AN_XN6XE9eNlqAwLerlqA__zOcxA
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB-kavGlav1otOoKgmBZmtvsVx6P1qNiPYofpW9LsrvBQpqUy1Xqf-9OkgvNoYL4kjzsbNhMfruzk5mdH8Cb2GlVxD6hTBSOcp06qmUWU29zm4hwlW3ZxdNjNZ_rs7P0pOc5bVbZ7quQZHemAas0Vcv9S1d0U1zL_SZYKY55QIKiD0DDJvI2R84gdNe_nA5hhIBG3ocyf9ttZIzWl-QbNmk9X3ItaNraotn9_36LB7DVb0PJtMPNQ7jlq2242xFT_tyGzU99yP0RLA4O03iPlJi_QSxiJNx8WTbkonbI_eWJrxye4yoDlNsmgnljNf7cJT0NULh7gvQswWaSuiD-um7qC98QHHDHUUGOJikpK_t5Pn0M32bvvx4c0Z6ogVoZJ0uaOOV9IYJ-MMemYFYJ5bNM5ZJbi_V3VJ7Fjlnc7HgnXOGctrlgRa681lYlT2Cjqiu_AwTPyYqEha5acGazsLyo8F3tpGBpbHMeQbz6Ysb2VcyRTKM0rTejpem0aoJWDWrVXEfwbuhy2ZXw-JvwW4SBwekdnmuz_pRCGB0WyjJTpE3XwUkVEeyOJMO0tOPmFZBMvyw0JgASHb6wykbwemjGnpjqVvn6CmVijjVqxSSCpx3uhmEzyRSTqYxAjRA5CGCx8HFLdf69LRrORSLDbiSCvRUubwzrT9p49k_Sr2Dz5HBmjj_MPz6He6zFtaYTvgsby8WVfwF37I_lebN42U7SX4jcPgg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=CD90%2B+liver+cancer+cells+modulate+endothelial+cell+phenotype+through+the+release+of+exosomes+containing+H19+lncRNA&rft.jtitle=Molecular+cancer&rft.au=Conigliaro%2C+Alice&rft.au=Costa%2C+Viviana&rft.au=Lo+Dico%2C+Alessia&rft.au=Saieva%2C+Laura&rft.date=2015-08-14&rft.issn=1476-4598&rft.eissn=1476-4598&rft.volume=14&rft.issue=1&rft_id=info:doi/10.1186%2Fs12943-015-0426-x&rft.externalDBID=n%2Fa&rft.externalDocID=10_1186_s12943_015_0426_x
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1476-4598&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1476-4598&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1476-4598&client=summon