HAlign-II: efficient ultra-large multiple sequence alignment and phylogenetic tree reconstruction with distributed and parallel computing

Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different...

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Published in:	Algorithms for molecular biology Vol. 12; no. 1; pp. 25 - 10
Main Authors:	Wan, Shixiang, Zou, Quan
Format:	Journal Article
Language:	English
Published:	London BioMed Central 29.09.2017 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Algorithms Alignment Analysis Bioinformatics Biological analysis Biological effects Biomedical and Life Sciences Cellular and Medical Topics Computational Biology/Bioinformatics Computer memory Computer networks Computing costs Computing time Datasets Deoxyribonucleic acid Design Distributed computing Distributed processing DNA DNA sequencing Efficiency Fault tolerance Fourier transforms Genomes International conferences Internet Internet server software Life Sciences Methods Multiple sequence alignment Nucleotide sequence Phylogenetic trees Phylogenetics Phylogeny Physiological Proteins Servers Software Software development tools Source code Spark Technology application China Phylogenetic trees Spark Multiple sequence alignment Distributed computing
ISSN:	1748-7188, 1748-7188
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Abstract	Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Methods Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. Results The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. Conclusions THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign .
AbstractList	Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign. Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Methods Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. Results The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. Conclusions THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign . Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign. Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Methods Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. Results The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. Conclusions THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at Keywords: Multiple sequence alignment, Phylogenetic trees, Distributed computing, Spark Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Methods Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. Results The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. Conclusions THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign. Abstract Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types. Methods Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction. Results The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource. Conclusions THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign . Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types.BACKGROUNDMultiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in next-generation sequencing results in shortage of efficient ultra-large biological sequence alignment approaches for coping with different sequence types.Distributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction.METHODSDistributed and parallel computing represents a crucial technique for accelerating ultra-large (e.g. files more than 1 GB) sequence analyses. Based on HAlign and Spark distributed computing system, we implement a highly cost-efficient and time-efficient HAlign-II tool to address ultra-large multiple biological sequence alignment and phylogenetic tree construction.The experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource.RESULTSThe experiments in the DNA and protein large scale data sets, which are more than 1GB files, showed that HAlign II could save time and space. It outperformed the current software tools. HAlign-II can efficiently carry out MSA and construct phylogenetic trees with ultra-large numbers of biological sequences. HAlign-II shows extremely high memory efficiency and scales well with increases in computing resource.THAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign.CONCLUSIONSTHAlign-II provides a user-friendly web server based on our distributed computing infrastructure. HAlign-II with open-source codes and datasets was established at http://lab.malab.cn/soft/halign.
ArticleNumber	25
Audience	Academic
Author	Zou, Quan Wan, Shixiang
Author_xml	– sequence: 1 givenname: Shixiang surname: Wan fullname: Wan, Shixiang organization: School of Computer Science and Technology, Tianjin University – sequence: 2 givenname: Quan surname: Zou fullname: Zou, Quan email: zouquan@tju.edu.cn organization: School of Computer Science and Technology, Tianjin University, Guangdong Province Key Laboratory of Popular High Performance Computers, Shenzhen University
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Cites_doi	10.1093/nar/gkr1246 10.1371/journal.pone.0098146 10.1101/gr.2286304 10.1093/bioinformatics/bth055 10.1093/bioinformatics/17.8.713 10.1093/bioinformatics/btt528 10.1145/2523616.2523633 10.1016/0167-8191(96)00024-5 10.1109/ICVD.2003.1183177 10.1093/bioinformatics/btq414 10.1186/s12859-017-1725-6 10.1093/bioinformatics/bts054 10.1186/1471-2105-11-S12-S1 10.1093/bioinformatics/btv177 10.1002/prot.20527 10.1093/bioinformatics/btq706 10.1093/nar/gkh340 10.1093/bioinformatics/btg192 10.1038/ncomms3304 10.1093/molbev/msw054 10.1016/0022-2836(81)90087-5 10.1186/1471-2105-6-298 10.1111/j.1558-5646.2011.01476.x 10.1016/j.sbi.2006.04.004 10.1109/CCGrid.2015.55 10.1007/s00791-008-0120-2 10.1093/bioinformatics/btu343 10.1093/bioinformatics/btu033 10.1093/bioinformatics/btt601 10.1093/molbev/msu300 10.1093/protein/gzm042 10.1101/gr.229202 10.1145/2783258.2789993 10.1038/msb.2011.75 10.1093/nar/gkf436 10.1109/BIBM.2016.7822492 10.1007/978-3-540-77220-0_21
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Keywords	Phylogenetic trees Spark Multiple sequence alignment Distributed computing
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References	Y Wu (116_CR35) 2012; 66 K Katoh (116_CR38) 2002; 30 W Gropp (116_CR14) 1996; 22 A Ahmadi (116_CR26) 2012; 40 C Xi (116_CR5) 2017; 18 J Ebedes (116_CR16) 2004; 20 116_CR19 J Tölke (116_CR4) 2010; 13 116_CR24 WJ Kent (116_CR25) 2002; 12 Q Zou (116_CR9) 2015; 31 A Trovato (116_CR34) 2007; 20 K Karplus (116_CR30) 2001; 17 A Schumacher (116_CR13) 2014; 30 116_CR20 N Segata (116_CR2) 2013; 4 JD Thompson (116_CR28) 2005; 61 RC Edgar (116_CR1) 2006; 16 W-C Chung (116_CR11) 2014; 9 116_CR3 MS Wiewiórka (116_CR21) 2014; 30 F Sievers (116_CR36) 2011; 7 116_CR6 N Saitou (116_CR23) 1987; 4 J Wang (116_CR27) 2010; 26 K-B Li (116_CR7) 2003; 19 L-T Nguyen (116_CR39) 2015; 32 A Stamatakis (116_CR33) 2014; 30 M Tanaka (116_CR29) 2004; 14 H Nordberg (116_CR12) 2013; 29 116_CR18 116_CR17 RC Taylor (116_CR15) 2010; 11 TF Smith (116_CR22) 1981; 147 S Kumar (116_CR40) 2016; 33 RC Edgar (116_CR37) 2004; 32 116_CR10 KP Schliep (116_CR32) 2011; 27 M Niemenmaa (116_CR8) 2012; 28 T Lassmann (116_CR31) 2005; 6 24845651 - Bioinformatics. 2014 Sep 15;30(18):2652-3 15034147 - Nucleic Acids Res. 2004 Mar 19;32(5):1792-7 25371430 - Mol Biol Evol. 2015 Jan;32(1):268-74 16679011 - Curr Opin Struct Biol. 2006 Jun;16(3):368-73 7265238 - J Mol Biol. 1981 Mar 25;147(1):195-7 11524372 - Bioinformatics. 2001 Aug;17(8):713-20 21210976 - BMC Bioinformatics. 2010 Dec 21;11 Suppl 12:S1 15466285 - Genome Res. 2004 Oct;14(10A):1832-50 24149054 - Bioinformatics. 2014 Jan 1;30(1):119-20 16044462 - Proteins. 2005 Oct 1;61(1):127-36 3447015 - Mol Biol Evol. 1987 Jul;4(4):406-25 22199254 - Nucleic Acids Res. 2012 Mar;40(6):e41 14764554 - Bioinformatics. 2004 May 1;20(7):1193-5 21988835 - Mol Syst Biol. 2011 Oct 11;7:539 28646874 - BMC Bioinformatics. 2017 Jun 24;18(1):315 22380439 - Evolution. 2012 Mar;66(3):763-775 16343337 - BMC Bioinformatics. 2005 Dec 12;6:298 24897343 - PLoS One. 2014 Jun 04;9(6):e98146 12136088 - Nucleic Acids Res. 2002 Jul 15;30(14):3059-66 21169378 - Bioinformatics. 2011 Feb 15;27(4):592-3 20624778 - Bioinformatics. 2010 Sep 15;26(18):2321-7 23942190 - Nat Commun. 2013;4:2304 12912844 - Bioinformatics. 2003 Aug 12;19(12):1585-6 22302568 - Bioinformatics. 2012 Mar 15;28(6):876-7 24021384 - Bioinformatics. 2013 Dec 1;29(23):3014-9 17720750 - Protein Eng Des Sel. 2007 Oct;20(10):521-3 24451623 - Bioinformatics. 2014 May 1;30(9):1312-3 11932250 - Genome Res. 2002 Apr;12(4):656-64 27004904 - Mol Biol Evol. 2016 Jul;33(7):1870-4 25812743 - Bioinformatics. 2015 Aug 1;31(15):2475-81
References_xml	– volume: 40 start-page: e41 year: 2012 ident: 116_CR26 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr1246 – volume: 9 start-page: e98146 year: 2014 ident: 116_CR11 publication-title: PLoS ONE doi: 10.1371/journal.pone.0098146 – volume: 14 start-page: 1832 year: 2004 ident: 116_CR29 publication-title: Genome Res doi: 10.1101/gr.2286304 – volume: 20 start-page: 1193 year: 2004 ident: 116_CR16 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bth055 – volume: 17 start-page: 713 year: 2001 ident: 116_CR30 publication-title: Bioinformatics doi: 10.1093/bioinformatics/17.8.713 – volume: 29 start-page: 3014 year: 2013 ident: 116_CR12 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt528 – ident: 116_CR18 doi: 10.1145/2523616.2523633 – volume: 22 start-page: 789 year: 1996 ident: 116_CR14 publication-title: Parallel Comput doi: 10.1016/0167-8191(96)00024-5 – ident: 116_CR20 doi: 10.1109/ICVD.2003.1183177 – ident: 116_CR17 – ident: 116_CR19 – volume: 26 start-page: 2321 year: 2010 ident: 116_CR27 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq414 – volume: 18 start-page: 315 year: 2017 ident: 116_CR5 publication-title: BMC Bioinform doi: 10.1186/s12859-017-1725-6 – volume: 28 start-page: 876 year: 2012 ident: 116_CR8 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts054 – volume: 11 start-page: S1 year: 2010 ident: 116_CR15 publication-title: BMC Bioinform doi: 10.1186/1471-2105-11-S12-S1 – volume: 31 start-page: 2475 year: 2015 ident: 116_CR9 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv177 – volume: 61 start-page: 127 year: 2005 ident: 116_CR28 publication-title: Proteins Struct Funct Bioinform doi: 10.1002/prot.20527 – volume: 27 start-page: 592 year: 2011 ident: 116_CR32 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq706 – volume: 32 start-page: 1792 year: 2004 ident: 116_CR37 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkh340 – volume: 19 start-page: 1585 year: 2003 ident: 116_CR7 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg192 – volume: 4 start-page: 406 year: 1987 ident: 116_CR23 publication-title: Mol Biol Evol – volume: 4 start-page: 2304 year: 2013 ident: 116_CR2 publication-title: Nat Commun doi: 10.1038/ncomms3304 – volume: 33 start-page: 1870 year: 2016 ident: 116_CR40 publication-title: Mol Biol Evol doi: 10.1093/molbev/msw054 – volume: 147 start-page: 195 year: 1981 ident: 116_CR22 publication-title: J Mol Biol doi: 10.1016/0022-2836(81)90087-5 – volume: 6 start-page: 298 year: 2005 ident: 116_CR31 publication-title: BMC Bioinform doi: 10.1186/1471-2105-6-298 – volume: 66 start-page: 763 year: 2012 ident: 116_CR35 publication-title: Evolution doi: 10.1111/j.1558-5646.2011.01476.x – volume: 16 start-page: 368 year: 2006 ident: 116_CR1 publication-title: Curr Opin Struct Biol doi: 10.1016/j.sbi.2006.04.004 – ident: 116_CR3 doi: 10.1109/CCGrid.2015.55 – volume: 13 start-page: 29 year: 2010 ident: 116_CR4 publication-title: Comput Vis Sci doi: 10.1007/s00791-008-0120-2 – volume: 30 start-page: 2652 year: 2014 ident: 116_CR21 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu343 – volume: 30 start-page: 1312 year: 2014 ident: 116_CR33 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu033 – volume: 30 start-page: 119 year: 2014 ident: 116_CR13 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt601 – volume: 32 start-page: 268 year: 2015 ident: 116_CR39 publication-title: Mol Biol Evol doi: 10.1093/molbev/msu300 – volume: 20 start-page: 521 year: 2007 ident: 116_CR34 publication-title: Protein Eng Des Sel doi: 10.1093/protein/gzm042 – volume: 12 start-page: 656 year: 2002 ident: 116_CR25 publication-title: Genome Res doi: 10.1101/gr.229202 – ident: 116_CR24 doi: 10.1145/2783258.2789993 – volume: 7 start-page: 1429 year: 2011 ident: 116_CR36 publication-title: Mol Syst Biol doi: 10.1038/msb.2011.75 – volume: 30 start-page: 3059 year: 2002 ident: 116_CR38 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkf436 – ident: 116_CR10 doi: 10.1109/BIBM.2016.7822492 – ident: 116_CR6 doi: 10.1007/978-3-540-77220-0_21 – reference: 23942190 - Nat Commun. 2013;4:2304 – reference: 22199254 - Nucleic Acids Res. 2012 Mar;40(6):e41 – reference: 25812743 - Bioinformatics. 2015 Aug 1;31(15):2475-81 – reference: 21210976 - BMC Bioinformatics. 2010 Dec 21;11 Suppl 12:S1 – reference: 22302568 - Bioinformatics. 2012 Mar 15;28(6):876-7 – reference: 16343337 - BMC Bioinformatics. 2005 Dec 12;6:298 – reference: 25371430 - Mol Biol Evol. 2015 Jan;32(1):268-74 – reference: 24021384 - Bioinformatics. 2013 Dec 1;29(23):3014-9 – reference: 12136088 - Nucleic Acids Res. 2002 Jul 15;30(14):3059-66 – reference: 22380439 - Evolution. 2012 Mar;66(3):763-775 – reference: 11932250 - Genome Res. 2002 Apr;12(4):656-64 – reference: 24845651 - Bioinformatics. 2014 Sep 15;30(18):2652-3 – reference: 12912844 - Bioinformatics. 2003 Aug 12;19(12):1585-6 – reference: 3447015 - Mol Biol Evol. 1987 Jul;4(4):406-25 – reference: 14764554 - Bioinformatics. 2004 May 1;20(7):1193-5 – reference: 20624778 - Bioinformatics. 2010 Sep 15;26(18):2321-7 – reference: 21169378 - Bioinformatics. 2011 Feb 15;27(4):592-3 – reference: 16044462 - Proteins. 2005 Oct 1;61(1):127-36 – reference: 24451623 - Bioinformatics. 2014 May 1;30(9):1312-3 – reference: 24149054 - Bioinformatics. 2014 Jan 1;30(1):119-20 – reference: 11524372 - Bioinformatics. 2001 Aug;17(8):713-20 – reference: 7265238 - J Mol Biol. 1981 Mar 25;147(1):195-7 – reference: 15034147 - Nucleic Acids Res. 2004 Mar 19;32(5):1792-7 – reference: 21988835 - Mol Syst Biol. 2011 Oct 11;7:539 – reference: 15466285 - Genome Res. 2004 Oct;14(10A):1832-50 – reference: 17720750 - Protein Eng Des Sel. 2007 Oct;20(10):521-3 – reference: 24897343 - PLoS One. 2014 Jun 04;9(6):e98146 – reference: 28646874 - BMC Bioinformatics. 2017 Jun 24;18(1):315 – reference: 27004904 - Mol Biol Evol. 2016 Jul;33(7):1870-4 – reference: 16679011 - Curr Opin Struct Biol. 2006 Jun;16(3):368-73
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Snippet	Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase... Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase in... Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme increase... Abstract Background Multiple sequence alignment (MSA) plays a key role in biological sequence analyses, especially in phylogenetic tree construction. Extreme...
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SubjectTerms	Algorithms Alignment Analysis Bioinformatics Biological analysis Biological effects Biomedical and Life Sciences Cellular and Medical Topics Computational Biology/Bioinformatics Computer memory Computer networks Computing costs Computing time Datasets Deoxyribonucleic acid Design Distributed computing Distributed processing DNA DNA sequencing Efficiency Fault tolerance Fourier transforms Genomes International conferences Internet Internet server software Life Sciences Methods Multiple sequence alignment Nucleotide sequence Phylogenetic trees Phylogenetics Phylogeny Physiological Proteins Servers Software Software development tools Source code Spark Technology application
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Title	HAlign-II: efficient ultra-large multiple sequence alignment and phylogenetic tree reconstruction with distributed and parallel computing
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