Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Phosphoenolpyruvate carboxykinase (PEPCK or PCK) catalyzes the first rate-limiting step in hepatic gluconeogenesis pathway to maintain blood glucose levels. Mammalian cells express two PCK genes, encoding for a cytoplasmic (PCPEK-C or PCK1) and a mitochondrial (PEPCK-M or PCK2) isoforms, respectivel...

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Veröffentlicht in:	Oncogene Jg. 37; H. 12; S. 1637 - 1653
Hauptverfasser:	Liu, Meng-Xi, Jin, Lei, Sun, Si-Jia, Liu, Peng, Feng, Xu, Cheng, Zhou-Li, Liu, Wei-Ren, Guan, Kun-Liang, Shi, Ying-Hong, Yuan, Hai-Xin, Xiong, Yue
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.03.2018 Nature Publishing Group
Schlagworte:	101/58 13/1 13/31 14/105 14/63 38/77 42/109 631/67 631/80 64/60 82/51 96/2 Animals Apoptosis Apoptosis - genetics Blood glucose Cancer Cancer cells Cancer genetics Carcinoma Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Biology Cell death Cell proliferation Cells (Biology) Cells, Cultured Cellular Reprogramming - genetics Citric Acid Cycle - genetics Colon Energy shortages Gene expression Genes Genes, Tumor Suppressor - physiology Genetic aspects Gluconeogenesis Gluconeogenesis - genetics Glucose HEK293 Cells Hep G2 Cells Hepatocellular carcinoma Hepatocytes Human Genetics Humans Internal Medicine Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - physiology Isoforms Ketoglutaric acid Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mammalian cells MCF-7 Cells Medicine Medicine & Public Health Metabolism Mice Mice, Inbred ICR Mice, Nude Mitochondria Oncology Oxidative stress Oxidative Stress - genetics Patients Phosphates Phosphoenolpyruvate Carboxykinase (GTP) - genetics Phosphoenolpyruvate Carboxykinase (GTP) - physiology Reactive oxygen species Rodents Skin Therapeutic applications Tumor cell lines Tumorigenesis Tumors
ISSN:	0950-9232, 1476-5594, 1476-5594
Online-Zugang:	Volltext
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