Statistical methods for analysis of high-throughput RNA interference screens

RNA interference (RNAi) has become a powerful technique for reverse genetics and drug discovery, and in both of these areas large-scale high-throughput RNAi screens are commonly performed. The statistical techniques used to analyze these screens are frequently borrowed directly from small-molecule s...

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Veröffentlicht in:	Nature methods Jg. 6; H. 8; S. 569 - 575
Hauptverfasser:	Birmingham, Amanda, Selfors, Laura M, Forster, Thorsten, Wrobel, David, Kennedy, Caleb J, Shanks, Emma, Santoyo-Lopez, Javier, Dunican, Dara J, Long, Aideen, Kelleher, Dermot, Smith, Queta, Beijersbergen, Roderick L, Ghazal, Peter, Shamu, Caroline E
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.08.2009 Nature Publishing Group
Schlagworte:	Animals Bioinformatics Biological Microscopy Biological Techniques Biomedical and Life Sciences Biomedical Engineering/Biotechnology Computer Simulation Genetic research Genetic screening Genetics Life Sciences Methods Models, Statistical Molecular biology Proteomics Research Design - statistics & numerical data review-article Ribonucleic acid RNA RNA Interference RNA, Small Interfering - chemistry RNA, Small Interfering - genetics Small Molecule Libraries Statistical methods United States
ISSN:	1548-7091, 1548-7105, 1548-7105
Online-Zugang:	Volltext
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