Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

Major depressive disorder (MDD) has been linked to changes in function and activity of the hippocampus, one of the central limbic regions involved in regulation of emotions and mood. The exact cellular and molecular mechanisms underlying hippocampal plasticity in response to stress are yet to be ful...

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Veröffentlicht in:	The international journal of neuropsychopharmacology Jg. 16; H. 1; S. 69 - 82
Hauptverfasser:	Duric, Vanja, Banasr, Mounira, Stockmeier, Craig A., Simen, Arthur A., Newton, Samuel S., Overholser, James C., Jurjus, George J., Dieter, Lesa, Duman, Ronald S.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cambridge, UK Cambridge University Press 01.02.2013 Oxford University Press
Schlagworte:	Adult Aged Aged, 80 and over Animals Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology Female Gene Expression Regulation Genes Guanylate Kinases - biosynthesis Guanylate Kinases - genetics Hippocampus - metabolism Hippocampus - pathology Humans Male Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Middle Aged Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Rats Rats, Sprague-Dawley Receptors, AMPA - biosynthesis Receptors, AMPA - genetics Receptors, Glutamate - biosynthesis Receptors, Glutamate - genetics Synapses - genetics Synapses - metabolism Synaptosomal-Associated Protein 25 - biosynthesis Synaptosomal-Associated Protein 25 - genetics Tumor Suppressor Proteins - biosynthesis Tumor Suppressor Proteins - genetics stress AMPA depression hippocampus post-mortem
ISSN:	1461-1457, 1469-5111, 1469-5111
Online-Zugang:	Volltext
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