Emerging rules for effective antimicrobial coatings

•Microbial biofilms can cause implant failure and are difficult to treat.•Antimicrobial peptides hold promise as surface active antimicrobial agents.•Multifunctional coatings with different architectures are available.•Standardized in vitro and in vivo testing procedures are needed to evaluate coati...

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Vydáno v:	Trends in biotechnology (Regular ed.) Ročník 32; číslo 2; s. 82 - 90
Hlavní autoři:	Salwiczek, Mario, Qu, Yue, Gardiner, James, Strugnell, Richard A., Lithgow, Trevor, McLean, Keith M., Thissen, Helmut
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cambridge, MA Elsevier Ltd 01.02.2014 Cell Press Elsevier Limited
Témata:	Anti-Infective Agents - pharmacology anti-infective coatings Antibiotic resistance Antibiotics Antimicrobial agents antimicrobial peptides antimicrobial properties bacteria Bacteria - drug effects Bacteria - growth & development Bacteriology biofilm Biofilms Biological and medical sciences Biotechnology Coatings Contact lenses Cross Infection - prevention & control E coli Equipment and Supplies - microbiology Fundamental and applied biological sciences. Psychology fungi Fungi - drug effects Fungi - growth & development hygiene implant infections Infection Control - methods Internal Medicine low-fouling polymers Medical equipment Molecular weight Peptides Polyethylene glycol Polymers Proteins Staphylococcus infections Surface Properties United States > US anti-infective coatings biofilms antimicrobial peptides implant infections low-fouling polymers Coatings Antimicrobial agent
ISSN:	0167-7799, 1879-3096, 1879-3096
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Popis
Shrnutí:	•Microbial biofilms can cause implant failure and are difficult to treat.•Antimicrobial peptides hold promise as surface active antimicrobial agents.•Multifunctional coatings with different architectures are available.•Standardized in vitro and in vivo testing procedures are needed to evaluate coatings. In order to colonize abiotic surfaces, bacteria and fungi undergo a profound change in their biology to form biofilms: communities of microbes embedded into a matrix of secreted macromolecules. Despite strict hygiene standards, biofilm-related infections associated with implantable devices remain a common complication in the clinic. Here, the application of highly dosed antibiotics is problematic in that the biofilm (i) provides a protective environment for microbes to evade antibiotics and/or (ii) can provide selective pressure for the evolution of antibiotic-resistant microbes. However, recent research suggests that effective prevention of biofilm formation may be achieved by multifunctional surface coatings that provide both non-adhesive and antimicrobial properties imparted by antimicrobial peptides. Such coatings are the subject of this review.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0167-7799 1879-3096 1879-3096
DOI:	10.1016/j.tibtech.2013.09.008