Intestinal epithelial cell transported TLR2 ligand stimulates Ly6C+ monocyte differentiation in a G-CSF dependent manner

Microflora-induced TLR signaling in the intestinal epithelium is essential for a proper intestinal barrier function. Because of the close interactions of this epithelial layer with underlying mononuclear phagocytes, we hypothesized that epithelial TLR signaling may affect the differentiation of myel...

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Bibliographic Details
Published in:	Immunobiology (1979) Vol. 220; no. 11; pp. 1255 - 1265
Main Authors:	Hiemstra, Ida H., Vrijland, Kim, Hogenboom, Marye M., Bouma, Gerd, Kraal, Georg, den Haan, Joke M.M.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier GmbH 01.11.2015
Subjects:	Advanced Basic Science Allergy and Immunology Animals Antigens, Ly - metabolism Cell Differentiation - drug effects Cells, Cultured Dendritic cell Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Granulocyte Colony-Stimulating Factor - biosynthesis Granulocyte Colony-Stimulating Factor - pharmacology Intestinal epithelial cells Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Leukocyte Count Ligands Lipopeptides - pharmacology Mice Microflora Monocyte differentiation Monocytes - drug effects Monocytes - physiology Toll-Like Receptor 2 - agonists Toll-Like Receptor 2 - metabolism Transcytosis Dendritic cell M-CSF GM-CSF Intestinal epithelial cells Microflora Flt3L BM TLR G-CSF Monocyte differentiation DC granulocyte macrophage colony-stimulating factor FMS-like tyrosine kinase 3 ligand granulocyte colony-stimulating factor bone marrow toll-like receptor dendritic cell macrophage colony-stimulating factor
ISSN:	0171-2985, 1878-3279
Online Access:	Get full text
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