Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement

The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common...

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Vydané v:	Neuroendocrinology Ročník 111; číslo 7; s. 609
Hlavní autori:	Niederle, Bruno, Selberherr, Andreas, Bartsch, Detlef K, Brandi, Maria L, Doherty, Gerard M, Falconi, Massimo, Goudet, Pierre, Halfdanarson, Thorvardur R, Ito, Tetsuhide, Jensen, Robert T, Larghi, Alberto, Lee, Lingaku, Öberg, Kjell, Pavel, Marianne, Perren, Aurel, Sadowski, Samira M, Tonelli, Francesco, Triponez, Frédéric, Valk, Gerlof D, O'Toole, Dermot, Scott-Coombes, David, Thakker, Rajesh V, Thompson, Geoffrey B, Treglia, Giorgio, Wiedenmann, Bertram
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland 01.06.2021
Predmet:	Consensus Duodenal Neoplasms - diagnosis Duodenal Neoplasms - therapy Humans Multiple Endocrine Neoplasia Type 1 - diagnosis Multiple Endocrine Neoplasia Type 1 - therapy Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - therapy Multiple endocrine neoplasia type 1 Treatment Diagnosis Consensus statement Neuroendocrine pancreatic tumors
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Abstract	The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies.
AbstractList	The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies.The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies. The better understanding of the biological behavior of multiple endocrine neoplasia type 1 (MEN1) organ manifestations and the increase in clinical experience warrant a revision of previously published guidelines. Duodenopancreatic neuroendocrine neoplasias (DP-NENs) are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to reevaluate recommendations for their diagnosis and treatment. Especially over the last 2 years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs. It was the aim of the international consortium of experts in endocrinology, genetics, radiology, surgery, gastroenterology, and oncology to systematically review the literature and to present a consensus statement based on the highest levels of evidence. Reviewing the literature published over the past decade, the focus was on the diagnosis of F- and NF-DP-NENs within the MEN1 syndrome in an effort to further standardize and improve treatment and follow-up, as well as to establish a "logbook" for the diagnosis and treatment of DP-NENs. This shall help further reduce complications and improve long-term treatment results in these rare tumors. The following international consensus statement builds upon the previously published guidelines of 2001 and 2012 and attempts to supplement the recommendations issued by various national and international societies.
Author	Halfdanarson, Thorvardur R Larghi, Alberto Brandi, Maria L Lee, Lingaku Jensen, Robert T Falconi, Massimo Treglia, Giorgio Selberherr, Andreas Bartsch, Detlef K O'Toole, Dermot Thakker, Rajesh V Öberg, Kjell Pavel, Marianne Tonelli, Francesco Perren, Aurel Thompson, Geoffrey B Niederle, Bruno Valk, Gerlof D Scott-Coombes, David Doherty, Gerard M Ito, Tetsuhide Wiedenmann, Bertram Goudet, Pierre Triponez, Frédéric Sadowski, Samira M
Author_xml	– sequence: 1 givenname: Bruno surname: Niederle fullname: Niederle, Bruno email: bruno.niederle@meduniwien.ac.at organization: Department of Surgery, Medical University of Vienna, Vienna, Austria, bruno.niederle@meduniwien.ac.at – sequence: 2 givenname: Andreas surname: Selberherr fullname: Selberherr, Andreas organization: Department of Surgery, Medical University of Vienna, Vienna, Austria – sequence: 3 givenname: Detlef K surname: Bartsch fullname: Bartsch, Detlef K organization: Department of Visceral, Thoracic and Vascular Surgery, Philipps University Marburg, Marburg, Germany – sequence: 4 givenname: Maria L surname: Brandi fullname: Brandi, Maria L organization: Firmo Lab, Fondazione F.I.R.M.O. and University Florence, Florence, Italy – sequence: 5 givenname: Gerard M surname: Doherty fullname: Doherty, Gerard M organization: Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA – sequence: 6 givenname: Massimo surname: Falconi fullname: Falconi, Massimo organization: Pancreatic Surgery, San Raffaele Scientific Institute, "Vita-Salute" University, Milan, Italy – sequence: 7 givenname: Pierre surname: Goudet fullname: Goudet, Pierre organization: Service de Chirurgie Viscérale et Endocrinienne, Centre Hospitalier Universitaire François Mitterand, Dijon, France – sequence: 8 givenname: Thorvardur R surname: Halfdanarson fullname: Halfdanarson, Thorvardur R organization: Department of Medical Oncology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA – sequence: 9 givenname: Tetsuhide surname: Ito fullname: Ito, Tetsuhide organization: Neuroendocrine Tumor Centre, Fukuoka Sanno Hospital and Department of Gastroenterology, Graduate School of Medical Sciences, International University of Health and Welfare, Sawara-ku, Fukuoka, Japan – sequence: 10 givenname: Robert T surname: Jensen fullname: Jensen, Robert T organization: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA – sequence: 11 givenname: Alberto surname: Larghi fullname: Larghi, Alberto organization: Digestive Endoscopy Unit, Fondazione Policlinico A. Gemelli IRCCS and Center for Endoscopic Research, Therapeutics and Training, Catholic University, Rome, Italy – sequence: 12 givenname: Lingaku surname: Lee fullname: Lee, Lingaku organization: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA – sequence: 13 givenname: Kjell surname: Öberg fullname: Öberg, Kjell organization: Endocrine Oncology, Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden – sequence: 14 givenname: Marianne surname: Pavel fullname: Pavel, Marianne organization: Endocrinology and Diabetology, Department of Medicine 1, University Clinic of Erlangen, Erlangen, Germany – sequence: 15 givenname: Aurel surname: Perren fullname: Perren, Aurel organization: Institute of Pathology, University of Bern, Bern, Switzerland – sequence: 16 givenname: Samira M surname: Sadowski fullname: Sadowski, Samira M organization: Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA – sequence: 17 givenname: Francesco surname: Tonelli fullname: Tonelli, Francesco organization: Department of Surgery and Translational Medicine, University of Florence, Florence, Italy – sequence: 18 givenname: Frédéric surname: Triponez fullname: Triponez, Frédéric organization: Thoracic and Endocrine Surgery, University Hospital of Geneva, Geneva, Switzerland – sequence: 19 givenname: Gerlof D surname: Valk fullname: Valk, Gerlof D organization: Department of Endocrine Oncology, University Medical Center Utrecht, Utrecht, The Netherlands – sequence: 20 givenname: Dermot surname: O'Toole fullname: O'Toole, Dermot organization: Department of Clinical Medicine, St. James's Hospital and St Vincent's University Hospital and Trinity College, Dublin, Ireland – sequence: 21 givenname: David surname: Scott-Coombes fullname: Scott-Coombes, David organization: Department of Endocrine Surgery, University Hospital of Wales, Cardiff, United Kingdom – sequence: 22 givenname: Rajesh V surname: Thakker fullname: Thakker, Rajesh V organization: Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford, United Kingdom – sequence: 23 givenname: Geoffrey B surname: Thompson fullname: Thompson, Geoffrey B organization: Section of Endocrine Surgery, Department of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, Minnesota, USA – sequence: 24 givenname: Giorgio surname: Treglia fullname: Treglia, Giorgio organization: Imaging Institute of Southern Switzerland, Ente Ospedaliero Cantonale, Bellinzona, Switzerland – sequence: 25 givenname: Bertram surname: Wiedenmann fullname: Wiedenmann, Bertram organization: Department of Gastroenterology and Hepatology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany
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Title	Multiple Endocrine Neoplasia Type 1 and the Pancreas: Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome - An International Consensus Statement
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