Lymphocytic choriomeningitis virus (LCMV) infection of macaques: A model for Lassa fever

► History of LCMV infections of primates (from mice to monkeys and man). ► Comparison of outcomes in murine and primate infections. ► Description of findings from LCMV-infected rhesus macaques. ► Utility of the model for testing host-response antivirals over virus-specific antivirals. Arenaviruses s...

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Bibliographic Details
Published in:Antiviral research Vol. 92; no. 2; pp. 125 - 138
Main Authors: Zapata, Juan C., Pauza, C. David, Djavani, Mahmoud M., Rodas, Juan D., Moshkoff, Dmitry, Bryant, Joseph, Ateh, Eugene, Garcia, Cybele, Lukashevich, Igor S., Salvato, Maria S.
Format: Journal Article
Language:English
Published: Kidlington Elsevier B.V 01.11.2011
Elsevier
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Arenaviridae Infections - pathology
Arenaviruses
Biological and medical sciences
Disease Models, Animal
Human viral diseases
Humans
Infectious diseases
Lassa Fever - pathology
Lassa fever and arenovirus diseases
Lassa fever virus
Lassa virus
LCMV
Lymphocytic choriomeningitis virus
Lymphocytic choriomeningitis virus - pathogenicity
Macaca mulatta
Medical sciences
Monkey models
Pharmacology. Drug treatments
Primates
Rhesus macaques
Tropical viral diseases
Viral diseases
Viral hemorrhagic fever
ML29
LCMV
sIL6R
Lassa fever virus
TACV
LCMV-WE
Rhesus macaques
PICV
Arenaviruses
MOPV
sc
Monkey models
AST/ALT
VHF
LCMV-ARM
ig
sTnfRI
im
Viral hemorrhagic fever
iv
IL-6
PMN
ffu
sTNFRII
LASV
pfu
Hemorrhagic fever
Monkey
Macaca mulatta
Lassa virus
Arenavirus
Virus
Infection
Vertebrata
Lassa fever
Mammalia
Lymphocytic choriomeningitis virus
Viral disease
Animal
Arbovirus disease
Primates
Simioidea
Models
Arenaviridae
ISSN:0166-3542, 1872-9096, 1872-9096
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Summary:► History of LCMV infections of primates (from mice to monkeys and man). ► Comparison of outcomes in murine and primate infections. ► Description of findings from LCMV-infected rhesus macaques. ► Utility of the model for testing host-response antivirals over virus-specific antivirals. Arenaviruses such as Lassa fever virus (LASV) and lymphocytic choriomeningitis virus (LCMV) are benign in their natural reservoir hosts, and can occasionally cause severe viral hemorrhagic fever (VHF) in non-human primates and in human beings. LCMV is considerably more benign for human beings than Lassa virus, however certain strains, like the LCMV-WE strain, can cause severe disease when the virus is delivered as a high-dose inoculum. Here we describe a rhesus macaque model for Lassa fever that employs a virulent strain of LCMV. Since LASV must be studied within Biosafety Level-4 (BSL-4) facilities, the LCMV-infected macaque model has the advantage that it can be used at BSL-3. LCMV-induced disease is rarely as severe as other VHF, but it is similar in cases where vascular leakage leads to lethal systemic failure. The LCMV-infected macaque has been valuable for describing the course of disease with differing viral strains, doses and routes of infection. By monitoring system-wide changes in physiology and gene expression in a controlled experimental setting, it is possible to identify events that are pathognomonic for developing VHF and potential treatment targets.
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ISSN:0166-3542
1872-9096
1872-9096
DOI:10.1016/j.antiviral.2011.07.015