Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

Acetaminophen (APAP) overdose is a common cause of drug-induced acute liver failure. Although hepatocyte cell death is considered to be the critical event in APAP-induced hepatotoxicity, the underlying mechanism remains unclear. Ferroptosis is a newly discovered type of cell death that is caused by...

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Bibliographic Details
Published in:	Cell death & disease Vol. 11; no. 2; pp. 144 - 16
Main Authors:	Yamada, Naoya, Karasawa, Tadayoshi, Kimura, Hiroaki, Watanabe, Sachiko, Komada, Takanori, Kamata, Ryo, Sampilvanjil, Ariunaa, Ito, Junya, Nakagawa, Kiyotaka, Kuwata, Hiroshi, Hara, Shuntaro, Mizuta, Koichi, Sakuma, Yasunaru, Sata, Naohiro, Takahashi, Masafumi
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.02.2020 Springer Nature B.V Nature Publishing Group
Subjects:	13 13/51 38 42 631/443 692/699/1503/1607/2749 82 82/58 Acetaminophen alpha-Tocopherol - pharmacology Analgesics Animal models Animals Antibodies Antioxidants - pharmacology Apoptosis Arachidonic acid Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell death Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Cyclohexylamines - pharmacology Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Deferoxamine Deferoxamine - pharmacology Disease Models, Animal Drug overdose Fatty acids Fatty Acids, Omega-6 - metabolism Ferroptosis Ferroptosis - drug effects Glutathione Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Hepatotoxicity Homeostasis Humans Immunology Iron Chelating Agents - pharmacology Life Sciences Lipid peroxidation Lipid Peroxidation - drug effects Lipids Liver Liver - drug effects Liver - metabolism Liver - pathology Liver failure Liver Failure, Acute - chemically induced Liver Failure, Acute - metabolism Liver Failure, Acute - pathology Liver Failure, Acute - prevention & control Mass spectroscopy Mice, Inbred C57BL Mice, Knockout mRNA Overdose Oxidation Oxidation-Reduction Phenylenediamines - pharmacology Polyunsaturated fatty acids Supplements Therapeutic applications Vitamin E
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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