Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

Synthetic biology has significantly advanced the design of genetic devices that can reprogram cellular activities and provide novel treatment strategies for future gene- and cell-based therapies. However, many metabolic disorders are functionally linked while developing distinct diseases that are di...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 110; H. 1; S. 141
Hauptverfasser:	Ye, Haifeng, Charpin-El Hamri, Ghislaine, Zwicky, Katharina, Christen, Matthias, Folcher, Marc, Fussenegger, Martin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.01.2013
Schlagworte:	Animals Cyclic AMP Response Element-Binding Protein - metabolism Dose-Response Relationship, Drug Drug Design Gene Expression Regulation - drug effects Glucagon-Like Peptide 1 - metabolism Guanabenz - pharmacology Leptin - metabolism Metabolic Syndrome - drug therapy Mice Models, Molecular Receptors, G-Protein-Coupled - metabolism Signal Transduction - drug effects Transgenes - genetics
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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