Comparison of virulence of Francisella tularensis ssp. holarctica genotypes B.12 and B.FTNF002-00

Background Two main genetic groups (B.12 and B.FTNF002-00) of Francisella tularensis ssp. holarctica are endemic in Europe. The B.FTNF002-00 group proved to be dominant in Western European countries, while strains of the B.12 group were isolated mainly in Northern, Central and Eastern Europe. The cl...

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Veröffentlicht in:BMC veterinary research Jg. 13; H. 1; S. 46
Hauptverfasser: Kreizinger, Zsuzsa, Erdélyi, Károly, Felde, Orsolya, Fabbi, Massimo, Sulyok, Kinga M., Magyar, Tibor, Gyuranecz, Miklós
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 10.02.2017
Springer Nature B.V
Schlagworte:
acute course
Animals
Bacteriology
Eastern European region
Europe
Female
Francisella tularensis
Francisella tularensis - classification
Francisella tularensis - genetics
Francisella tularensis - pathogenicity
Genotype
hares
Lepus europaeus
Medicine
Medicine & Public Health
Rats
Research Article
Transgenics
tularemia
Tularemia - parasitology
Tularemia - pathology
Veterinary Medicine/Veterinary Science
virulence
Virulence - genetics
Weight Loss
Zoology
Eastern European region
Europe
B.13
Experimental infection
B.12
Fischer 344 rat
Tularemia
B.FTNF002-00
Brown hare
ISSN:1746-6148, 1746-6148
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Zusammenfassung:Background Two main genetic groups (B.12 and B.FTNF002-00) of Francisella tularensis ssp. holarctica are endemic in Europe. The B.FTNF002-00 group proved to be dominant in Western European countries, while strains of the B.12 group were isolated mainly in Northern, Central and Eastern Europe. The clinical course of tularemia in the European brown hare ( Lepus europaeus ) also shows distinct patterns according to the geographical area. Acute course of the disease is observed in hares in Western European countries, while signs of sub-acute or chronic infection are more frequently detected in the eastern part of the continent. The aim of the present study was to examine whether there is any difference in the virulence of the strains belonging to the B.FTNF002-00 and B.12 genetic clades. Results Experimental infection of Fischer 344 rats was performed by intra-peritoneal injection of three dilutions of a Hungarian (B.12 genotype) and an Italian (B.FTNF002-00 genotype) F. tularensis ssp. holarctica strain. Moderate difference was observed in the virulence of the two genotypes. Significant differences were observed in total weight loss values and scores of clinical signs between the two genotypes with more rats succumbing to tularemia in groups infected with the B.FTNF002-00 genotype. Conclusions Results of the experimental infection are consistent with previous clinical observations and pathological studies suggesting that F. tularensis ssp. holarctica genotype B.FTNF002-00 has higher pathogenic potential than the B.12 genotype.
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ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-017-0968-9