Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study

EORTC trial 22921 examined the addition of preoperative or postoperative chemotherapy to preoperative radiotherapy in patients with rectal cancer. After a median follow-up of 5 years, chemotherapy—irrespective of timing—significantly improved local control. Adjuvant chemotherapy did not improve surv...

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Veröffentlicht in:	The lancet oncology Jg. 15; H. 2; S. 184 - 190
Hauptverfasser:	Bosset, Jean-François, Calais, Gilles, Mineur, Laurent, Maingon, Philippe, Stojanovic-Rundic, Suzana, Bensadoun, René-Jean, Bardet, Etienne, Beny, Alexander, Ollier, Jean-Claude, Bolla, Michel, Marchal, Dominique, Van Laethem, Jean-Luc, Klein, Vincent, Giralt, Jordi, Clavère, Pierre, Glanzmann, Christoph, Cellier, Patrice, Collette, Laurence
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.02.2014 Elsevier Limited Elsevier
Schlagworte:	Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Cancer therapies Cellular Biology Chemoradiotherapy, Adjuvant - adverse effects Chemoradiotherapy, Adjuvant - mortality Chemotherapy Chemotherapy, Adjuvant Colorectal cancer Digestive System Surgical Procedures - adverse effects Digestive System Surgical Procedures - mortality Disease Progression Disease-Free Survival Europe Female Fluorouracil - administration & dosage Hematology, Oncology and Palliative Medicine Humans Intention to Treat Analysis Israel Kaplan-Meier Estimate Leucovorin - administration & dosage Life Sciences Male Medical treatment Middle Aged Neoadjuvant Therapy - adverse effects Neoadjuvant Therapy - mortality Neoplasm Staging Proportional Hazards Models Radiation therapy Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - therapy Risk Factors Studies Surgery Survival Rate Time Factors Treatment Outcome Ultrasonic imaging Young Adult Europe Israel
ISSN:	1470-2045, 1474-5488, 1474-5488
Online-Zugang:	Volltext
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