Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution

During recombinational repair of double-stranded DNA breaks, RAD51 recombinase assembles as a nucleoprotein filament around single-stranded DNA to form a catalytically proficient structure able to promote homology recognition and strand exchange. Mediators and accessory factors guide the action and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 111; H. 42; S. 15090
Hauptverfasser:	Candelli, Andrea, Holthausen, Jan Thomas, Depken, Martin, Brouwer, Ineke, Franker, Mariëlla A M, Marchetti, Margherita, Heller, Iddo, Bernard, Stéphanie, Garcin, Edwige B, Modesti, Mauro, Wyman, Claire, Wuite, Gijs J L, Peterman, Erwin J G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.10.2014
Schlagworte:	Cell Nucleus - metabolism DNA, Single-Stranded - chemistry Fluorescent Dyes - chemistry Humans Likelihood Functions Microfluidics Microscopy, Fluorescence Optical Tweezers Rad51 Recombinase - chemistry Recombination, Genetic Reproducibility of Results RNA, Small Interfering - metabolism Stochastic Processes Substrate Specificity optical tweezers RAD51 homologous recombination single-molecule fluorescence BRCA2
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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