Targeting p38 MAP kinase signaling in cancer through post-translational modifications

The p38 MAPK signaling pathway is a key signal transduction cascade that cancer cells employ to sense and adapt to a plethora of environmental stimuli, and has attracted much attention as a promising target for cancer therapy. Accumulating evidence suggests a dual role of p38 signaling in various ty...

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Bibliographic Details
Published in:	Cancer letters Vol. 384; pp. 19 - 26
Main Authors:	Zou, Xiao, Blank, Michael
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01.01.2017 Elsevier Limited
Subjects:	Acetylation Animals Antineoplastic Agents - therapeutic use Cancer Cell cycle Chemotherapy Drug Design Hematology, Oncology and Palliative Medicine Humans Inflammation Kinases Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - pathology p38 MAPK signaling pathway p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphatase Phosphorylation Protein Kinase Inhibitors - therapeutic use Protein Processing, Post-Translational - drug effects Proteins PTM Regulation Roles Signal transduction Signal Transduction - drug effects Stress response Ubiquitination PTM Chemotherapy Ubiquitination p38 MAPK signaling pathway Cancer
ISSN:	0304-3835, 1872-7980, 1872-7980
Online Access:	Get full text
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