Targeting p38 MAP kinase signaling in cancer through post-translational modifications

The p38 MAPK signaling pathway is a key signal transduction cascade that cancer cells employ to sense and adapt to a plethora of environmental stimuli, and has attracted much attention as a promising target for cancer therapy. Accumulating evidence suggests a dual role of p38 signaling in various ty...

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Vydáno v:	Cancer letters Ročník 384; s. 19 - 26
Hlavní autoři:	Zou, Xiao, Blank, Michael
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Ireland Elsevier Ireland Ltd 01.01.2017 Elsevier Limited
Témata:	Acetylation Animals Antineoplastic Agents - therapeutic use Cancer Cell cycle Chemotherapy Drug Design Hematology, Oncology and Palliative Medicine Humans Inflammation Kinases Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - pathology p38 MAPK signaling pathway p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Phosphatase Phosphorylation Protein Kinase Inhibitors - therapeutic use Protein Processing, Post-Translational - drug effects Proteins PTM Regulation Roles Signal transduction Signal Transduction - drug effects Stress response Ubiquitination PTM Chemotherapy Ubiquitination p38 MAPK signaling pathway Cancer
ISSN:	0304-3835, 1872-7980, 1872-7980
On-line přístup:	Získat plný text
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