Monogenic and polygenic determinants of sarcoma risk: an international genetic study

Sarcomas are rare, phenotypically heterogeneous cancers that disproportionately affect the young. Outside rare syndromes, the nature, extent, and clinical significance of their genetic origins are not known. We aimed to investigate the genetic basis for bone and soft-tissue sarcoma seen in routine c...

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Veröffentlicht in:	The lancet oncology Jg. 17; H. 9; S. 1261 - 1271
Hauptverfasser:	Ballinger, Mandy L, Goode, David L, Ray-Coquard, Isabelle, James, Paul A, Mitchell, Gillian, Niedermayr, Eveline, Puri, Ajay, Schiffman, Joshua D, Dite, Gillian S, Cipponi, Arcadi, Maki, Robert G, Brohl, Andrew S, Myklebost, Ola, Stratford, Eva W, Lorenz, Susanne, Ahn, Sung-Min, Ahn, Jin-Hee, Kim, Jeong Eun, Shanley, Sue, Beshay, Victoria, Randall, Robert Lor, Judson, Ian, Seddon, Beatrice, Campbell, Ian G, Young, Mary-Anne, Sarin, Rajiv, Blay, Jean-Yves, O'Donoghue, Seán I, Thomas, David M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Elsevier Ltd 01.09.2016 Elsevier Limited
Schlagworte:	Adolescent Adult Age Aged Aged, 80 and over Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Breast cancer Case-Control Studies Cell cycle Child Child, Preschool Classification Disease Exome - genetics Family medical history Female Follow-Up Studies Genes Genetic diversity Genomes Genotype & phenotype Health risk assessment Hematology, Oncology and Palliative Medicine High-Throughput Nucleotide Sequencing - methods Humans Infant Infant, Newborn International Agencies Male Mammography Medical research Middle Aged Mutation Mutation - genetics Neoplasm Staging Pedigree Population Prognosis Risk Factors Saliva Saliva - chemistry Sarcoma Sarcoma - blood Sarcoma - genetics Studies Young Adult
ISSN:	1470-2045, 1474-5488, 1474-5488
Online-Zugang:	Volltext
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