Tumor microenvironment and therapeutic response
•Tumor microenvironment (TME) influences therapeutic response and clinical outcome.•TME mediated resistance results from continuous crosstalk between tumor cells and stroma.•Targeting TME compartments could improve the effectiveness of current treatment. The tumor microenvironment significantly infl...
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| Published in: | Cancer letters Vol. 387; pp. 61 - 68 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Ireland
Elsevier B.V
28.02.2017
Elsevier Limited |
| Subjects: | |
| ISSN: | 0304-3835, 1872-7980 |
| Online Access: | Get full text |
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| Abstract | •Tumor microenvironment (TME) influences therapeutic response and clinical outcome.•TME mediated resistance results from continuous crosstalk between tumor cells and stroma.•Targeting TME compartments could improve the effectiveness of current treatment.
The tumor microenvironment significantly influences therapeutic response and clinical outcome. Microenvironment-mediated drug resistance can be induced by soluble factors secreted by tumor or stromal cells. The adhesion of tumor cells to stromal fibroblasts or to components of the extracellular matrix can also blunt therapeutic response. Microenvironment-targeted therapy strategies include inhibition of the extracellular ligand–receptor interactions and downstream pathways. Immune cells can both improve and obstruct therapeutic efficacy and may vary in their activation status within the tumor microenvironment; thus, re-programme of the immune response would be substantially more beneficial. The development of rational drug combinations that can simultaneously target tumor cells and the microenvironment may represent a solution to overcome therapeutic resistance. |
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| AbstractList | •Tumor microenvironment (TME) influences therapeutic response and clinical outcome.•TME mediated resistance results from continuous crosstalk between tumor cells and stroma.•Targeting TME compartments could improve the effectiveness of current treatment.
The tumor microenvironment significantly influences therapeutic response and clinical outcome. Microenvironment-mediated drug resistance can be induced by soluble factors secreted by tumor or stromal cells. The adhesion of tumor cells to stromal fibroblasts or to components of the extracellular matrix can also blunt therapeutic response. Microenvironment-targeted therapy strategies include inhibition of the extracellular ligand–receptor interactions and downstream pathways. Immune cells can both improve and obstruct therapeutic efficacy and may vary in their activation status within the tumor microenvironment; thus, re-programme of the immune response would be substantially more beneficial. The development of rational drug combinations that can simultaneously target tumor cells and the microenvironment may represent a solution to overcome therapeutic resistance. The tumor microenvironment significantly influences therapeutic response and clinical outcome. Microenvironment-mediated drug resistance can be induced by soluble factors secreted by tumor or stromal cells. The adhesion of tumor cells to stromal fibroblasts or to components of the extracellular matrix can also blunt therapeutic response. Microenvironment-targeted therapy strategies include inhibition of the extracellular ligand-receptor interactions and downstream pathways. Immune cells can both improve and obstruct therapeutic efficacy and may vary in their activation status within the tumor microenvironment; thus, re-programme of the immune response would be substantially more beneficial. The development of rational drug combinations that can simultaneously target tumor cells and the microenvironment may represent a solution to overcome therapeutic resistance. Highlights • Tumor microenvironment (TME) influences therapeutic response and clinical outcome. • TME mediated resistance results from continuous crosstalk between tumor cells and stroma. • Targeting TME compartments could improve the effectiveness of current treatment. |
| Author | Dai, Yun Wu, Ting |
| Author_xml | – sequence: 1 givenname: Ting surname: Wu fullname: Wu, Ting – sequence: 2 givenname: Yun surname: Dai fullname: Dai, Yun email: daiyun1@medmail.com.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26845449$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2353/ajpath.2009.090202 10.1038/nm.2999 10.1016/S1470-2045(15)00132-1 10.1038/35094059 10.1016/j.intimp.2011.01.030 10.1182/blood-2011-10-383406 10.1182/blood-2009-08-237412 10.1158/0008-5472.CAN-05-3387 10.1189/jlb.71.3.495 10.1016/j.cell.2010.03.014 10.1016/S0092-8674(00)81731-6 10.1016/j.cell.2005.02.034 10.1182/blood-2008-05-158311 10.1038/nri3902 10.1038/nm909 10.1038/nrc1877 10.1007/s10637-012-9869-8 10.1182/blood.V95.8.2630 10.1146/annurev-immunol-032712-100008 10.1101/gad.180331.111 10.1007/s00262-009-0747-y 10.1158/0008-5472.CAN-05-3523 10.1016/j.ajpath.2011.11.029 10.1038/cdd.2013.67 10.1016/j.semcancer.2008.03.004 10.1038/onc.2013.357 10.1016/j.ccr.2012.02.017 10.1126/scitranslmed.3007974 10.1182/blood.V88.2.667.bloodjournal882667 10.1016/j.ccr.2014.05.016 10.1016/j.ccell.2014.09.006 10.1002/ijc.24401 10.1111/j.1365-2141.2011.08864.x 10.18632/oncotarget.3099 10.1158/0008-5472.CAN-11-2449 10.1007/s10549-009-0502-2 10.1038/sj.bjc.6603176 10.1007/s00262-003-0459-7 10.1038/nrc3581 10.1038/nm.3394 10.1084/jem.20080108 10.1172/JCI26532 10.1182/blood-2004-12-4918 10.1097/JTO.0b013e3181a97e31 10.1172/JCI66553 10.4049/jimmunol.159.5.2212 10.1158/0008-5472.CAN-05-3077 10.1007/s11060-014-1365-x 10.1002/eji.201242505 10.1007/s00280-013-2099-8 10.1016/j.humimm.2009.01.014 10.1182/blood-2012-01-406272 10.1016/j.bbrc.2013.06.089 10.1016/j.immuni.2013.07.017 10.1007/s10637-012-9857-z 10.1073/pnas.1106645108 10.1038/nature06348 10.1074/jbc.M110.168617 10.1002/path.4133 10.1016/j.tcb.2014.11.006 10.1158/1078-0432.CCR-13-1320 10.1073/pnas.0902280106 10.1002/eji.200324270 10.1016/j.cell.2011.02.013 10.1093/jnci/djm135 10.1593/neo.11324 10.1016/j.ygyno.2013.12.031 10.1016/j.molonc.2014.03.016 10.1530/JOE-10-0377 10.1002/eji.201142335 10.1016/j.cell.2012.04.042 10.1158/0008-5472.CAN-07-6390 10.1007/s10637-010-9573-5 10.1182/blood-2002-09-2907 10.1038/nm.3560 10.1007/s11523-014-0320-2 10.1016/j.it.2015.02.004 10.1182/blood-2004-03-0889 10.1038/nature11183 10.1016/S1470-2045(14)70379-1 10.4161/cc.8.10.8557 10.1038/sj.cdd.4401849 10.1038/nm.3291 10.1093/neuonc/not082 10.1084/jem.20061104 10.1084/jem.20150295 10.1158/2159-8274.CD-10-0028 10.1158/0008-5472.CAN-07-2593 10.1073/pnas.94.5.1785 10.1016/j.ccr.2012.04.025 10.1016/j.yexcr.2010.04.032 10.1111/j.1365-2141.1994.tb05017.x 10.1038/sj.leu.2400556 10.1158/0008-5472.CAN-06-4639 10.1182/blood.V98.2.428 10.1002/cncr.24821 10.1158/1078-0432.CCR-09-3272 10.1084/jem.176.5.1319 10.1182/blood.V99.11.4138 10.1038/onc.2010.350 10.1038/nri3175 10.1016/j.bcp.2013.01.018 10.1016/S1535-6108(03)00058-8 10.1158/0008-5472.CAN-10-3055 10.1016/j.ccr.2012.02.022 10.1074/jbc.C300173200 10.1038/nbt1323 10.1038/nm.3337 10.1016/j.cell.2013.12.041 10.1158/1078-0432.CCR-08-1612 10.1126/science.1198443 10.1007/s00262-013-1396-8 10.1038/sj.onc.1204554 10.18632/oncotarget.1893 10.1038/nrc2714 10.1097/JTO.0000000000000193 10.1158/0008-5472.CAN-12-3542 10.1182/blood.V96.8.2655 |
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| References | Sherman-Baust, Weeraratna, Rangel, Pizer, Cho, Schwartz (bib0330) 2003; 3 Matsunaga, Takemoto, Sato, Takimoto, Tanaka, Fujimi (bib0305) 2003; 9 Shree, Olson, Elie, Kester, Garfall, Simpson (bib0135) 2011; 25 Bruchard, Mignot, Derangere, Chalmin, Chevriaux, Vegran (bib0395) 2013; 19 Kim, Turnbull, Guimond (bib0210) 2011; 209 Shojaei, Wu, Malik, Zhong, Baldwin, Schanz (bib0130) 2007; 25 Jewell, Worman, Lydyard, Yong, Giles, Goldstone (bib0275) 1994; 88 Talmadge, Gabrilovich (bib0185) 2013; 13 Nishio, Endo, Tsukada, Ohata, Kitada, Reed (bib0240) 2005; 106 Podar, Zimmerhackl, Fulciniti, Tonon, Hainz, Tai (bib0445) 2011; 155 Orimo, Gupta, Sgroi, Arenzana-Seisdedos, Delaunay, Naeem (bib0050) 2005; 121 Fujita, Kohanbash, Fellows-Mayle, Hamilton, Komohara, Decker (bib0555) 2011; 71 Misra, Ghatak, Zoltan-Jones, Toole (bib0340) 2003; 278 Burger, Tsukada, Burger, Zvaifler, Dell'Aquila, Kipps (bib0235) 2000; 96 Akino, Hida, Hida, Tsuchiya, Freedman, Muraki (bib0160) 2009; 175 Lathers, Clark, Achille, Young (bib0575) 2004; 53 Griffioen, Damen, Blijham, Groenewegen (bib0180) 1996; 88 Bayne, Beatty, Jhala, Clark, Rhim, Stanger (bib0525) 2012; 21 Lin, Podar, Gupta, Tai, Li, Weller (bib0415) 2002; 62 Qian, Pollard (bib0080) 2010; 141 Nakasone, Askautrud, Kees, Park, Plaks, Ewald (bib0355) 2012; 21 Alva, Slovin, Daignault, Carducci, Dipaola, Pienta (bib0460) 2012; 30 Bisping, Leo, Wenning, Dankbar, Padro, Kropff (bib0290) 2003; 101 Weizman, Krelin, Shabtay-Orbach, Amit, Binenbaum, Wong (bib0370) 2014; 33 Eisele, Wick, Eisele, Clement, Tonn, Tabatabai (bib0465) 2014; 117 Konig, Menzel, Lynen, Wrazel, Rosen, Al-Katib (bib0280) 1997; 11 Obermajer, Muthuswamy, Odunsi, Edwards, Kalinski (bib0545) 2011; 71 Bracci, Schiavoni, Sistigu, Belardelli (bib0595) 2014; 21 Margolin, Silinsky, Grimes, Spencer, Aycock, Green (bib0250) 2011; 13 Hudes, Tagawa, Whang, Qi, Qin, Puchalski (bib0430) 2013; 31 Hanahan, Coussens (bib0010) 2012; 21 Lu-Emerson, Snuderl, Kirkpatrick, Goveia, Davidson, Huang (bib0380) 2013; 15 Hersey, Sosman, O'Day, Richards, Bedikian, Gonzalez (bib0470) 2010; 116 Priceman, Sung, Shaposhnik, Burton, Torres-Collado, Moughon (bib0530) 2010; 115 Chen, Jacamo, Konopleva, Garzon, Croce, Andreeff (bib0245) 2013; 123 Qiang, Kopantzev, Rudikoff (bib0265) 2002; 99 Song, Smith, Doshi, Sasser, Fulp, Altiok (bib0425) 2014; 9 Pyonteck, Akkari, Schuhmacher, Bowman, Sevenich, Quail (bib0510) 2013; 19 Mulligan, Day, Gillespie, Rosenzweig, Young (bib0195) 2009; 70 Amin, Hida, Bielenberg, Klagsbrun (bib0165) 2006; 66 Mantovani, Allavena (bib0120) 2015; 212 Podar, Tai, Davies, Lentzsch, Sattler, Hideshima (bib0260) 2001; 98 Netti, Berk, Swartz, Grodzinsky, Jain (bib0220) 2000; 60 Fukunaga-Kalabis, Martinez, Nguyen, Kim, Santiago-Walker, Roesch (bib0320) 2010; 29 Kalluri, Zeisberg (bib0045) 2006; 6 Brana, Calles, LoRusso, Yee, Puchalski, Seetharam (bib0505) 2015; 10 Straussman, Morikawa, Shee, Barzily-Rokni, Qian, Du (bib0070) 2012; 487 Akiyama, Ohga, Hida, Kawamoto, Sadamoto, Ishikawa (bib0170) 2012; 180 de la Fuente, Casanova, Moyano, Garcia-Gila, Sanz, Garcia-Marco (bib0300) 2002; 71 DeNardo, Brennan, Rexhepaj, Ruffell, Shiao, Madden (bib0110) 2011; 1 Ries, Cannarile, Hoves, Benz, Wartha, Runza (bib0480) 2014; 25 Gabrusiewicz, Liu, Cortes-Santiago, Hossain, Conrad, Aldape (bib0375) 2014; 5 Pienta, Machiels, Schrijvers, Alekseev, Shkolnik, Crabb (bib0500) 2013; 31 Loeffler, Kruger, Niethammer, Reisfeld (bib0335) 2006; 116 Beatty, Chiorean, Fishman, Saboury, Teitelbaum, Sun (bib0515) 2011; 331 Nagaraj, Youn, Weber, Iclozan, Lu, Cotter (bib0565) 2010; 16 Nefedova, Fishman, Sherman, Wang, Beg, Gabrilovich (bib0570) 2007; 67 Sica, Larghi, Mancino, Rubino, Porta, Totaro (bib0090) 2008; 18 Acharyya, Oskarsson, Vanharanta, Malladi, Kim, Morris (bib0150) 2012; 150 Chung, Wu, Zhuang, Ngu, Kasman, Zhang (bib0390) 2013; 19 Kroemer, Galluzzi, Kepp, Zitvogel (bib0590) 2013; 31 Anderberg, Pietras (bib0060) 2009; 8 Zhan, Wang, Lv, Wang, Qiu, Lin (bib0035) 2009; 4 Mantovani, Biswas, Galdiero, Sica, Locati (bib0105) 2013; 229 Shojaei, Wu, Zhong, Yu, Liang, Yao (bib0385) 2007; 450 Fukumura, Xavier, Sugiura, Chen, Park, Lu (bib0030) 1998; 94 Weigelt, Lo, Park, Gray, Bissell (bib0440) 2010; 122 Paraiso, Smalley (bib0075) 2013; 85 Scalici, Harrer, Allen, Jazaeri, Atkins, McLachlan (bib0450) 2014; 132 Ruffell, Chang-Strachan, Chan, Rosenbusch, Ho, Pryer (bib0360) 2014; 26 Ogata, Chauhan, Teoh, Treon, Urashima, Schlossman (bib0255) 1997; 159 Klemm, Joyce (bib0350) 2015; 25 Iclozan, Antonia, Chiappori, Chen, Gabrilovich (bib0580) 2013; 62 Dancescu, Rubio-Trujillo, Biron, Bron, Delespesse, Sarfati (bib0270) 1992; 176 Rasanen, Vaheri (bib0055) 2010; 316 Grantab, Sivananthan, Tannock (bib0215) 2006; 66 Mulligan, Young (bib0200) 2010; 59 Serafini, Meckel, Kelso, Noonan, Califano, Koch (bib0560) 2006; 203 Meads, Gatenby, Dalton (bib0230) 2009; 9 Finke, Ko, Rini, Rayman, Ireland, Cohen (bib0155) 2011; 11 Des Guetz, Uzzan, Nicolas, Cucherat, Morere, Benamouzig (bib0040) 2006; 94 Paulus, Stanley, Schafer, Abraham, Aharinejad (bib0125) 2006; 66 Ma, Galluzzi, Zitvogel, Kroemer (bib0600) 2013; 39 Hodkinson, Elliott, Wong, Rintoul, Mackinnon, Haslett (bib0310) 2006; 13 Sandhu, Papadopoulos, Fong, Patnaik, Messiou, Olmos (bib0495) 2013; 71 Beatty, Torigian, Chiorean, Saboury, Brothers, Alavi (bib0520) 2013; 19 Highfill, Cui, Giles, Smith, Zhang, Morse (bib0540) 2014; 6 Jinushi, Chiba, Yoshiyama, Masutomi, Kinoshita, Dosaka-Akita (bib0365) 2011; 108 Aoudjit, Vuori (bib0315) 2001; 20 Qin, Lerman, Sakamaki, Wei, Cha, Rao (bib0550) 2014; 20 Erez, Glanz, Raz, Avivi, Barshack (bib0065) 2013; 437 Hanahan, Weinberg (bib0020) 2011; 144 Bisping, Wenning, Kropff, Gustavus, Muller-Tidow, Stelljes (bib0420) 2009; 15 Pallasch, Leskov, Braun, Vorholt, Drake, Soto-Feliciano (bib0610) 2014; 156 Hannesdottir, Tymoszuk, Parajuli, Wasmer, Philipp, Daschil (bib0605) 2013; 43 Burger, Hartmann, Krome, Rawluk, Tamamura, Fujii (bib0400) 2005; 106 Hsieh, Gang, Geng, Park, Huantes, Chudziak (bib0455) 2013; 121 Shojaei, Wu, Qu, Kowanetz, Yu, Tan (bib0145) 2009; 106 Park, Zhang, Yao, Park, Bissell (bib0435) 2008; 68 Duluc, Corvaisier, Blanchard, Catala, Descamps, Gamelin (bib0095) 2009; 125 Zhang, Wu, Guan, Wang, Ren, Shi (bib0295) 2015; 6 Stupp, Hegi, Gorlia, Erridge, Perry, Hong (bib0475) 2014; 15 Cassier, Italiano, Gomez-Roca, Le Tourneau, Toulmonde, Cannarile (bib0485) 2015; 16 Rodig, Ryan, Allen, Pang, Grabie, Chernova (bib0190) 2003; 33 Quail, Joyce (bib0015) 2013; 19 Uy, Rettig, Motabi, McFarland, Trinkaus, Hladnik (bib0410) 2012; 119 Ostuni, Kratochvill, Murray, Natoli (bib0085) 2015; 36 Turley, Cremasco, Astarita (bib0175) 2015; 15 Bissell, Radisky (bib0205) 2001; 1 Dijkgraaf, Heusinkveld, Tummers, Vogelpoel, Goedemans, Jha (bib0115) 2013; 73 Dankbar, Padro, Leo, Feldmann, Kropff, Mesters (bib0285) 2000; 95 Ko, Kim, Kim, Chang, Ko, Chang (bib0585) 2007; 67 Hagemann, Lawrence, McNeish, Charles, Kulbe, Thompson (bib0100) 2008; 205 Berube, Talbot, Collin, Paquet-Bouchard, Germain, Guerin (bib0325) 2005; 26 Gabrilovich, Ostrand-Rosenberg, Bronte (bib0140) 2012; 12 Berk, Yuan, Leunig, Jain (bib0225) 1997; 94 Zigrino, Nischt, Mauch (bib0345) 2011; 286 Sumida, Wakita, Narita, Masuko, Terada, Watanabe (bib0535) 2012; 42 Zeng, Shi, Samudio, Wang, Ling, Frolova (bib0405) 2009; 113 Tredan, Galmarini, Patel, Tannock (bib0025) 2007; 99 Moisan, Francisco, Brozovic, Duran, Wang, Chaturvedi (bib0490) 2014; 8 Kalluri (10.1016/j.canlet.2016.01.043_bib0045) 2006; 6 Kroemer (10.1016/j.canlet.2016.01.043_bib0590) 2013; 31 Hanahan (10.1016/j.canlet.2016.01.043_bib0020) 2011; 144 Podar (10.1016/j.canlet.2016.01.043_bib0260) 2001; 98 Serafini (10.1016/j.canlet.2016.01.043_bib0560) 2006; 203 Gabrilovich (10.1016/j.canlet.2016.01.043_bib0140) 2012; 12 Grantab (10.1016/j.canlet.2016.01.043_bib0215) 2006; 66 Dancescu (10.1016/j.canlet.2016.01.043_bib0270) 1992; 176 Moisan (10.1016/j.canlet.2016.01.043_bib0490) 2014; 8 Duluc (10.1016/j.canlet.2016.01.043_bib0095) 2009; 125 Margolin (10.1016/j.canlet.2016.01.043_bib0250) 2011; 13 Weigelt (10.1016/j.canlet.2016.01.043_bib0440) 2010; 122 Hannesdottir (10.1016/j.canlet.2016.01.043_bib0605) 2013; 43 Chung (10.1016/j.canlet.2016.01.043_bib0390) 2013; 19 Brana (10.1016/j.canlet.2016.01.043_bib0505) 2015; 10 Matsunaga (10.1016/j.canlet.2016.01.043_bib0305) 2003; 9 Hodkinson (10.1016/j.canlet.2016.01.043_bib0310) 2006; 13 Bisping (10.1016/j.canlet.2016.01.043_bib0420) 2009; 15 Highfill (10.1016/j.canlet.2016.01.043_bib0540) 2014; 6 Berk (10.1016/j.canlet.2016.01.043_bib0225) 1997; 94 Hsieh (10.1016/j.canlet.2016.01.043_bib0455) 2013; 121 Beatty (10.1016/j.canlet.2016.01.043_bib0515) 2011; 331 Nagaraj (10.1016/j.canlet.2016.01.043_bib0565) 2010; 16 Zhang (10.1016/j.canlet.2016.01.043_bib0295) 2015; 6 Hersey (10.1016/j.canlet.2016.01.043_bib0470) 2010; 116 Nefedova (10.1016/j.canlet.2016.01.043_bib0570) 2007; 67 Shojaei (10.1016/j.canlet.2016.01.043_bib0145) 2009; 106 Burger (10.1016/j.canlet.2016.01.043_bib0235) 2000; 96 Ostuni (10.1016/j.canlet.2016.01.043_bib0085) 2015; 36 Zigrino (10.1016/j.canlet.2016.01.043_bib0345) 2011; 286 Griffioen (10.1016/j.canlet.2016.01.043_bib0180) 1996; 88 Berube (10.1016/j.canlet.2016.01.043_bib0325) 2005; 26 Cassier (10.1016/j.canlet.2016.01.043_bib0485) 2015; 16 Sumida (10.1016/j.canlet.2016.01.043_bib0535) 2012; 42 Paulus (10.1016/j.canlet.2016.01.043_bib0125) 2006; 66 Rasanen (10.1016/j.canlet.2016.01.043_bib0055) 2010; 316 Park (10.1016/j.canlet.2016.01.043_bib0435) 2008; 68 Bayne (10.1016/j.canlet.2016.01.043_bib0525) 2012; 21 Song (10.1016/j.canlet.2016.01.043_bib0425) 2014; 9 Nishio (10.1016/j.canlet.2016.01.043_bib0240) 2005; 106 Weizman (10.1016/j.canlet.2016.01.043_bib0370) 2014; 33 Talmadge (10.1016/j.canlet.2016.01.043_bib0185) 2013; 13 Beatty (10.1016/j.canlet.2016.01.043_bib0520) 2013; 19 Mantovani (10.1016/j.canlet.2016.01.043_bib0120) 2015; 212 Bissell (10.1016/j.canlet.2016.01.043_bib0205) 2001; 1 Ma (10.1016/j.canlet.2016.01.043_bib0600) 2013; 39 Nakasone (10.1016/j.canlet.2016.01.043_bib0355) 2012; 21 Fukumura (10.1016/j.canlet.2016.01.043_bib0030) 1998; 94 Bracci (10.1016/j.canlet.2016.01.043_bib0595) 2014; 21 Alva (10.1016/j.canlet.2016.01.043_bib0460) 2012; 30 Turley (10.1016/j.canlet.2016.01.043_bib0175) 2015; 15 Jewell (10.1016/j.canlet.2016.01.043_bib0275) 1994; 88 Shojaei (10.1016/j.canlet.2016.01.043_bib0385) 2007; 450 Zhan (10.1016/j.canlet.2016.01.043_bib0035) 2009; 4 Lu-Emerson (10.1016/j.canlet.2016.01.043_bib0380) 2013; 15 Ko (10.1016/j.canlet.2016.01.043_bib0585) 2007; 67 Tredan (10.1016/j.canlet.2016.01.043_bib0025) 2007; 99 Burger (10.1016/j.canlet.2016.01.043_bib0400) 2005; 106 DeNardo (10.1016/j.canlet.2016.01.043_bib0110) 2011; 1 Ruffell (10.1016/j.canlet.2016.01.043_bib0360) 2014; 26 Zeng (10.1016/j.canlet.2016.01.043_bib0405) 2009; 113 Akino (10.1016/j.canlet.2016.01.043_bib0160) 2009; 175 Chen (10.1016/j.canlet.2016.01.043_bib0245) 2013; 123 Straussman (10.1016/j.canlet.2016.01.043_bib0070) 2012; 487 de la Fuente (10.1016/j.canlet.2016.01.043_bib0300) 2002; 71 Pallasch (10.1016/j.canlet.2016.01.043_bib0610) 2014; 156 Des Guetz (10.1016/j.canlet.2016.01.043_bib0040) 2006; 94 Qian (10.1016/j.canlet.2016.01.043_bib0080) 2010; 141 Podar (10.1016/j.canlet.2016.01.043_bib0445) 2011; 155 Mantovani (10.1016/j.canlet.2016.01.043_bib0105) 2013; 229 Gabrusiewicz (10.1016/j.canlet.2016.01.043_bib0375) 2014; 5 Obermajer (10.1016/j.canlet.2016.01.043_bib0545) 2011; 71 Aoudjit (10.1016/j.canlet.2016.01.043_bib0315) 2001; 20 Ogata (10.1016/j.canlet.2016.01.043_bib0255) 1997; 159 Pienta (10.1016/j.canlet.2016.01.043_bib0500) 2013; 31 Netti (10.1016/j.canlet.2016.01.043_bib0220) 2000; 60 Paraiso (10.1016/j.canlet.2016.01.043_bib0075) 2013; 85 Mulligan (10.1016/j.canlet.2016.01.043_bib0200) 2010; 59 Mulligan (10.1016/j.canlet.2016.01.043_bib0195) 2009; 70 Sica (10.1016/j.canlet.2016.01.043_bib0090) 2008; 18 Klemm (10.1016/j.canlet.2016.01.043_bib0350) 2015; 25 Akiyama (10.1016/j.canlet.2016.01.043_bib0170) 2012; 180 Bisping (10.1016/j.canlet.2016.01.043_bib0290) 2003; 101 Priceman (10.1016/j.canlet.2016.01.043_bib0530) 2010; 115 Anderberg (10.1016/j.canlet.2016.01.043_bib0060) 2009; 8 Rodig (10.1016/j.canlet.2016.01.043_bib0190) 2003; 33 Jinushi (10.1016/j.canlet.2016.01.043_bib0365) 2011; 108 Scalici (10.1016/j.canlet.2016.01.043_bib0450) 2014; 132 Iclozan (10.1016/j.canlet.2016.01.043_bib0580) 2013; 62 Hagemann (10.1016/j.canlet.2016.01.043_bib0100) 2008; 205 Hanahan (10.1016/j.canlet.2016.01.043_bib0010) 2012; 21 Lin (10.1016/j.canlet.2016.01.043_bib0415) 2002; 62 Dijkgraaf (10.1016/j.canlet.2016.01.043_bib0115) 2013; 73 Qin (10.1016/j.canlet.2016.01.043_bib0550) 2014; 20 Loeffler (10.1016/j.canlet.2016.01.043_bib0335) 2006; 116 Sandhu (10.1016/j.canlet.2016.01.043_bib0495) 2013; 71 Pyonteck (10.1016/j.canlet.2016.01.043_bib0510) 2013; 19 Amin (10.1016/j.canlet.2016.01.043_bib0165) 2006; 66 Uy (10.1016/j.canlet.2016.01.043_bib0410) 2012; 119 Hudes (10.1016/j.canlet.2016.01.043_bib0430) 2013; 31 Finke (10.1016/j.canlet.2016.01.043_bib0155) 2011; 11 Stupp (10.1016/j.canlet.2016.01.043_bib0475) 2014; 15 Shree (10.1016/j.canlet.2016.01.043_bib0135) 2011; 25 Bruchard (10.1016/j.canlet.2016.01.043_bib0395) 2013; 19 Fukunaga-Kalabis (10.1016/j.canlet.2016.01.043_bib0320) 2010; 29 Orimo (10.1016/j.canlet.2016.01.043_bib0050) 2005; 121 Konig (10.1016/j.canlet.2016.01.043_bib0280) 1997; 11 Shojaei (10.1016/j.canlet.2016.01.043_bib0130) 2007; 25 Dankbar (10.1016/j.canlet.2016.01.043_bib0285) 2000; 95 Meads (10.1016/j.canlet.2016.01.043_bib0230) 2009; 9 Sherman-Baust (10.1016/j.canlet.2016.01.043_bib0330) 2003; 3 Eisele (10.1016/j.canlet.2016.01.043_bib0465) 2014; 117 Fujita (10.1016/j.canlet.2016.01.043_bib0555) 2011; 71 Ries (10.1016/j.canlet.2016.01.043_bib0480) 2014; 25 Misra (10.1016/j.canlet.2016.01.043_bib0340) 2003; 278 Acharyya (10.1016/j.canlet.2016.01.043_bib0150) 2012; 150 Quail (10.1016/j.canlet.2016.01.043_bib0015) 2013; 19 Erez (10.1016/j.canlet.2016.01.043_bib0065) 2013; 437 Qiang (10.1016/j.canlet.2016.01.043_bib0265) 2002; 99 Kim (10.1016/j.canlet.2016.01.043_bib0210) 2011; 209 Lathers (10.1016/j.canlet.2016.01.043_bib0575) 2004; 53 |
| References_xml | – volume: 209 start-page: 139 year: 2011 end-page: 151 ident: bib0210 article-title: Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor publication-title: J. Endocrinol – volume: 155 start-page: 438 year: 2011 end-page: 448 ident: bib0445 article-title: The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications publication-title: Br. J. Haematol – volume: 156 start-page: 590 year: 2014 end-page: 602 ident: bib0610 article-title: Sensitizing protective tumor microenvironments to antibody-mediated therapy publication-title: Cell – volume: 85 start-page: 1033 year: 2013 end-page: 1041 ident: bib0075 article-title: Fibroblast-mediated drug resistance in cancer publication-title: Biochem. Pharmacol – volume: 286 start-page: 6801 year: 2011 end-page: 6807 ident: bib0345 article-title: The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts publication-title: J. Biol. Chem – volume: 19 start-page: 1114 year: 2013 end-page: 1123 ident: bib0390 article-title: An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy publication-title: Nat. Med – volume: 60 start-page: 2497 year: 2000 end-page: 2503 ident: bib0220 article-title: Role of extracellular matrix assembly in interstitial transport in solid tumors publication-title: Cancer Res – volume: 106 start-page: 1824 year: 2005 end-page: 1830 ident: bib0400 article-title: Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells publication-title: Blood – volume: 18 start-page: 349 year: 2008 end-page: 355 ident: bib0090 article-title: Macrophage polarization in tumour progression publication-title: Semin. Cancer Biol – volume: 5 start-page: 2208 year: 2014 end-page: 2220 ident: bib0375 article-title: Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes publication-title: Oncotarget – volume: 229 start-page: 176 year: 2013 end-page: 185 ident: bib0105 article-title: Macrophage plasticity and polarization in tissue repair and remodelling publication-title: J. Pathol – volume: 123 start-page: 2395 year: 2013 end-page: 2407 ident: bib0245 article-title: CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia publication-title: J. Clin. Invest – volume: 71 start-page: 1041 year: 2013 end-page: 1050 ident: bib0495 article-title: A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors publication-title: Cancer Chemother. Pharmacol – volume: 26 start-page: 623 year: 2014 end-page: 637 ident: bib0360 article-title: Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells publication-title: Cancer Cell – volume: 4 start-page: 1094 year: 2009 end-page: 1103 ident: bib0035 article-title: Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis publication-title: J. Thorac. Oncol – volume: 6 start-page: 392 year: 2006 end-page: 401 ident: bib0045 article-title: Fibroblasts in cancer publication-title: Nat. Rev. Cancer – volume: 150 start-page: 165 year: 2012 end-page: 178 ident: bib0150 article-title: A CXCL1 paracrine network links cancer chemoresistance and metastasis publication-title: Cell – volume: 62 start-page: 909 year: 2013 end-page: 918 ident: bib0580 article-title: Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer publication-title: Cancer Immunol. Immunother – volume: 62 start-page: 5019 year: 2002 end-page: 5026 ident: bib0415 article-title: The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment publication-title: Cancer Res – volume: 159 start-page: 2212 year: 1997 end-page: 2221 ident: bib0255 article-title: IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade publication-title: J. Immunol – volume: 67 start-page: 7477 year: 2007 end-page: 7486 ident: bib0585 article-title: A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model publication-title: Cancer Res – volume: 96 start-page: 2655 year: 2000 end-page: 2663 ident: bib0235 article-title: Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1 publication-title: Blood – volume: 94 start-page: 1785 year: 1997 end-page: 1790 ident: bib0225 article-title: Direct publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 101 start-page: 2775 year: 2003 end-page: 2783 ident: bib0290 article-title: Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma publication-title: Blood – volume: 66 start-page: 1033 year: 2006 end-page: 1039 ident: bib0215 article-title: The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells publication-title: Cancer Res – volume: 212 start-page: 435 year: 2015 end-page: 445 ident: bib0120 article-title: The interaction of anticancer therapies with tumor-associated macrophages publication-title: J. Exp. Med – volume: 3 start-page: 377 year: 2003 end-page: 386 ident: bib0330 article-title: Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells publication-title: Cancer Cell – volume: 39 start-page: 211 year: 2013 end-page: 227 ident: bib0600 article-title: Autophagy and cellular immune responses publication-title: Immunity – volume: 20 start-page: 4995 year: 2001 end-page: 5004 ident: bib0315 article-title: Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells publication-title: Oncogene – volume: 108 start-page: 12425 year: 2011 end-page: 12430 ident: bib0365 article-title: Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 125 start-page: 367 year: 2009 end-page: 373 ident: bib0095 article-title: Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages publication-title: Int. J. Cancer – volume: 132 start-page: 455 year: 2014 end-page: 461 ident: bib0450 article-title: Inhibition of alpha4beta1 integrin increases ovarian cancer response to carboplatin publication-title: Gynecol. Oncol – volume: 316 start-page: 2713 year: 2010 end-page: 2722 ident: bib0055 article-title: Activation of fibroblasts in cancer stroma publication-title: Exp. Cell Res – volume: 70 start-page: 375 year: 2009 end-page: 382 ident: bib0195 article-title: Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions publication-title: Hum. Immunol – volume: 9 start-page: 665 year: 2009 end-page: 674 ident: bib0230 article-title: Environment-mediated drug resistance: a major contributor to minimal residual disease publication-title: Nat. Rev. Cancer – volume: 95 start-page: 2630 year: 2000 end-page: 2636 ident: bib0285 article-title: Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma publication-title: Blood – volume: 21 start-page: 15 year: 2014 end-page: 25 ident: bib0595 article-title: Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer publication-title: Cell Death Differ – volume: 15 start-page: 1100 year: 2014 end-page: 1108 ident: bib0475 article-title: Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial publication-title: Lancet Oncol – volume: 25 start-page: 198 year: 2015 end-page: 213 ident: bib0350 article-title: Microenvironmental regulation of therapeutic response in cancer publication-title: Trends Cell Biol – volume: 43 start-page: 2718 year: 2013 end-page: 2729 ident: bib0605 article-title: Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response publication-title: Eur. J. Immunol – volume: 98 start-page: 428 year: 2001 end-page: 435 ident: bib0260 article-title: Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration publication-title: Blood – volume: 13 start-page: 1776 year: 2006 end-page: 1788 ident: bib0310 article-title: ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase publication-title: Cell Death Differ – volume: 117 start-page: 141 year: 2014 end-page: 145 ident: bib0465 article-title: Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression publication-title: J. Neurooncol – volume: 99 start-page: 1441 year: 2007 end-page: 1454 ident: bib0025 article-title: Drug resistance and the solid tumor microenvironment publication-title: J. Natl. Cancer Inst – volume: 73 start-page: 2480 year: 2013 end-page: 2492 ident: bib0115 article-title: Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment publication-title: Cancer Res – volume: 15 start-page: 1079 year: 2013 end-page: 1087 ident: bib0380 article-title: Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma publication-title: Neuro Oncol – volume: 8 start-page: 1231 year: 2014 end-page: 1239 ident: bib0490 article-title: Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers publication-title: Mol. Oncol – volume: 9 start-page: 974 year: 2014 end-page: 982 ident: bib0425 article-title: Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer publication-title: J. Thorac. Oncol – volume: 31 start-page: 760 year: 2013 end-page: 768 ident: bib0500 article-title: Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer publication-title: Invest. New Drugs – volume: 11 start-page: 856 year: 2011 end-page: 861 ident: bib0155 article-title: MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy publication-title: Int. Immunopharmacol – volume: 59 start-page: 267 year: 2010 end-page: 277 ident: bib0200 article-title: Tumors induce the formation of suppressor endothelial cells publication-title: Cancer Immunol. Immunother – volume: 487 start-page: 500 year: 2012 end-page: 504 ident: bib0070 article-title: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion publication-title: Nature – volume: 99 start-page: 4138 year: 2002 end-page: 4146 ident: bib0265 article-title: Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk publication-title: Blood – volume: 122 start-page: 35 year: 2010 end-page: 43 ident: bib0440 article-title: HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment publication-title: Breast Cancer Res. Treat – volume: 19 start-page: 57 year: 2013 end-page: 64 ident: bib0395 article-title: Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth publication-title: Nat. Med – volume: 6 start-page: 3085 year: 2015 end-page: 3097 ident: bib0295 article-title: Paracrine SDF-1alpha signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells publication-title: Oncotarget – volume: 71 start-page: 495 year: 2002 end-page: 502 ident: bib0300 article-title: Engagement of alpha4beta1 integrin by fibronectin induces publication-title: J. Leukoc. Biol – volume: 106 start-page: 6742 year: 2009 end-page: 6747 ident: bib0145 article-title: G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 116 start-page: 1526 year: 2010 end-page: 1534 ident: bib0470 article-title: A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or − dacarbazine in patients with stage IV metastatic melanoma publication-title: Cancer – volume: 115 start-page: 1461 year: 2010 end-page: 1471 ident: bib0530 article-title: Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy publication-title: Blood – volume: 42 start-page: 2060 year: 2012 end-page: 2072 ident: bib0535 article-title: Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses publication-title: Eur. J. Immunol – volume: 25 start-page: 846 year: 2014 end-page: 859 ident: bib0480 article-title: Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy publication-title: Cancer Cell – volume: 88 start-page: 268 year: 1994 end-page: 274 ident: bib0275 article-title: Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis publication-title: Br. J. Haematol – volume: 9 start-page: 1158 year: 2003 end-page: 1165 ident: bib0305 article-title: Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia publication-title: Nat. Med – volume: 66 start-page: 4349 year: 2006 end-page: 4356 ident: bib0125 article-title: Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts publication-title: Cancer Res – volume: 11 start-page: 258 year: 1997 end-page: 265 ident: bib0280 article-title: Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis publication-title: Leukemia – volume: 119 start-page: 3917 year: 2012 end-page: 3924 ident: bib0410 article-title: A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia publication-title: Blood – volume: 33 start-page: 3117 year: 2003 end-page: 3126 ident: bib0190 article-title: Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis publication-title: Eur. J. Immunol – volume: 21 start-page: 309 year: 2012 end-page: 322 ident: bib0010 article-title: Accessories to the crime: functions of cells recruited to the tumor microenvironment publication-title: Cancer Cell – volume: 13 start-page: 739 year: 2013 end-page: 752 ident: bib0185 article-title: History of myeloid-derived suppressor cells publication-title: Nat. Rev. Cancer – volume: 19 start-page: 1423 year: 2013 end-page: 1437 ident: bib0015 article-title: Microenvironmental regulation of tumor progression and metastasis publication-title: Nat. Med – volume: 71 start-page: 7463 year: 2011 end-page: 7470 ident: bib0545 article-title: PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment publication-title: Cancer Res – volume: 67 start-page: 11021 year: 2007 end-page: 11028 ident: bib0570 article-title: Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells publication-title: Cancer Res – volume: 94 start-page: 715 year: 1998 end-page: 725 ident: bib0030 article-title: Tumor induction of VEGF promoter activity in stromal cells publication-title: Cell – volume: 15 start-page: 520 year: 2009 end-page: 531 ident: bib0420 article-title: Bortezomib, dexamethasone, and fibroblast growth factor receptor 3-specific tyrosine kinase inhibitor in t(4;14) myeloma publication-title: Clin. Cancer Res – volume: 15 start-page: 669 year: 2015 end-page: 682 ident: bib0175 article-title: Immunological hallmarks of stromal cells in the tumour microenvironment publication-title: Nat. Rev. Immunol – volume: 121 start-page: 1814 year: 2013 end-page: 1818 ident: bib0455 article-title: Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy publication-title: Blood – volume: 16 start-page: 949 year: 2015 end-page: 956 ident: bib0485 article-title: CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study publication-title: Lancet Oncol – volume: 68 start-page: 4398 year: 2008 end-page: 4405 ident: bib0435 article-title: Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts publication-title: Cancer Res – volume: 19 start-page: 1264 year: 2013 end-page: 1272 ident: bib0510 article-title: CSF-1R inhibition alters macrophage polarization and blocks glioma progression publication-title: Nat. Med – volume: 71 start-page: 2664 year: 2011 end-page: 2674 ident: bib0555 article-title: COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells publication-title: Cancer Res – volume: 25 start-page: 911 year: 2007 end-page: 920 ident: bib0130 article-title: Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells publication-title: Nat. Biotechnol – volume: 12 start-page: 253 year: 2012 end-page: 268 ident: bib0140 article-title: Coordinated regulation of myeloid cells by tumours publication-title: Nat. Rev. Immunol – volume: 21 start-page: 822 year: 2012 end-page: 835 ident: bib0525 article-title: Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer publication-title: Cancer Cell – volume: 175 start-page: 2657 year: 2009 end-page: 2667 ident: bib0160 article-title: Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors publication-title: Am. J. Pathol – volume: 94 start-page: 1823 year: 2006 end-page: 1832 ident: bib0040 article-title: Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature publication-title: Br. J. Cancer – volume: 10 start-page: 111 year: 2015 end-page: 123 ident: bib0505 article-title: Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study publication-title: Target. Oncol – volume: 21 start-page: 488 year: 2012 end-page: 503 ident: bib0355 article-title: Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance publication-title: Cancer Cell – volume: 176 start-page: 1319 year: 1992 end-page: 1326 ident: bib0270 article-title: Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression publication-title: J. Exp. Med – volume: 16 start-page: 1812 year: 2010 end-page: 1823 ident: bib0565 article-title: Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer publication-title: Clin. Cancer Res – volume: 106 start-page: 1012 year: 2005 end-page: 1020 ident: bib0240 article-title: Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha publication-title: Blood – volume: 6 start-page: 237ra267 year: 2014 ident: bib0540 article-title: Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy publication-title: Sci. Transl. Med – volume: 31 start-page: 669 year: 2013 end-page: 676 ident: bib0430 article-title: A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer publication-title: Invest. New Drugs – volume: 33 start-page: 3812 year: 2014 end-page: 3819 ident: bib0370 article-title: Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase publication-title: Oncogene – volume: 180 start-page: 1283 year: 2012 end-page: 1293 ident: bib0170 article-title: Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment publication-title: Am. J. Pathol – volume: 30 start-page: 749 year: 2012 end-page: 757 ident: bib0460 article-title: Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium publication-title: Invest. New Drugs – volume: 88 start-page: 667 year: 1996 end-page: 673 ident: bib0180 article-title: Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium publication-title: Blood – volume: 31 start-page: 51 year: 2013 end-page: 72 ident: bib0590 article-title: Immunogenic cell death in cancer therapy publication-title: Annu. Rev. Immunol – volume: 116 start-page: 1955 year: 2006 end-page: 1962 ident: bib0335 article-title: Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake publication-title: J. Clin. Invest – volume: 144 start-page: 646 year: 2011 end-page: 674 ident: bib0020 article-title: Hallmarks of cancer: the next generation publication-title: Cell – volume: 1 start-page: 54 year: 2011 end-page: 67 ident: bib0110 article-title: Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy publication-title: Cancer Discov – volume: 53 start-page: 422 year: 2004 end-page: 430 ident: bib0575 article-title: Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3 publication-title: Cancer Immunol. Immunother – volume: 8 start-page: 1461 year: 2009 end-page: 1462 ident: bib0060 article-title: On the origin of cancer-associated fibroblasts publication-title: Cell Cycle – volume: 331 start-page: 1612 year: 2011 end-page: 1616 ident: bib0515 article-title: CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans publication-title: Science – volume: 205 start-page: 1261 year: 2008 end-page: 1268 ident: bib0100 article-title: “Re-educating” tumor-associated macrophages by targeting NF-kappaB publication-title: J. Exp. Med – volume: 25 start-page: 2465 year: 2011 end-page: 2479 ident: bib0135 article-title: Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer publication-title: Genes Dev – volume: 437 start-page: 397 year: 2013 end-page: 402 ident: bib0065 article-title: Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors publication-title: Biochem. Biophys. Res. Commun – volume: 121 start-page: 335 year: 2005 end-page: 348 ident: bib0050 article-title: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion publication-title: Cell – volume: 113 start-page: 6215 year: 2009 end-page: 6224 ident: bib0405 article-title: Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML publication-title: Blood – volume: 1 start-page: 46 year: 2001 end-page: 54 ident: bib0205 article-title: Putting tumours in context publication-title: Nat. Rev. Cancer – volume: 13 start-page: 874 year: 2011 end-page: 886 ident: bib0250 article-title: Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1alpha/CXCR4 paracrine signaling publication-title: Neoplasia – volume: 20 start-page: 676 year: 2014 end-page: 681 ident: bib0550 article-title: Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice publication-title: Nat. Med – volume: 66 start-page: 2173 year: 2006 end-page: 2180 ident: bib0165 article-title: Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors publication-title: Cancer Res – volume: 141 start-page: 39 year: 2010 end-page: 51 ident: bib0080 article-title: Macrophage diversity enhances tumor progression and metastasis publication-title: Cell – volume: 36 start-page: 229 year: 2015 end-page: 239 ident: bib0085 article-title: Macrophages and cancer: from mechanisms to therapeutic implications publication-title: Trends Immunol – volume: 19 start-page: 6286 year: 2013 end-page: 6295 ident: bib0520 article-title: A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma publication-title: Clin. Cancer Res – volume: 450 start-page: 825 year: 2007 end-page: 831 ident: bib0385 article-title: Bv8 regulates myeloid-cell-dependent tumour angiogenesis publication-title: Nature – volume: 278 start-page: 25285 year: 2003 end-page: 25288 ident: bib0340 article-title: Regulation of multidrug resistance in cancer cells by hyaluronan publication-title: J. Biol. Chem – volume: 203 start-page: 2691 year: 2006 end-page: 2702 ident: bib0560 article-title: Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function publication-title: J. Exp. Med – volume: 26 start-page: 405 year: 2005 end-page: 413 ident: bib0325 article-title: Role of the extracellular matrix proteins in the resistance of SP6.5 uveal melanoma cells toward cisplatin publication-title: Int. J. Oncol – volume: 29 start-page: 6115 year: 2010 end-page: 6124 ident: bib0320 article-title: Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population publication-title: Oncogene – volume: 175 start-page: 2657 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0160 article-title: Cytogenetic abnormalities of tumor-associated endothelial cells in human malignant tumors publication-title: Am. J. Pathol doi: 10.2353/ajpath.2009.090202 – volume: 19 start-page: 57 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0395 article-title: Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth publication-title: Nat. Med doi: 10.1038/nm.2999 – volume: 16 start-page: 949 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0485 article-title: CSF1R inhibition with emactuzumab in locally advanced diffuse-type tenosynovial giant cell tumours of the soft tissue: a dose-escalation and dose-expansion phase 1 study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(15)00132-1 – volume: 1 start-page: 46 year: 2001 ident: 10.1016/j.canlet.2016.01.043_bib0205 article-title: Putting tumours in context publication-title: Nat. Rev. Cancer doi: 10.1038/35094059 – volume: 11 start-page: 856 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0155 article-title: MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy publication-title: Int. Immunopharmacol doi: 10.1016/j.intimp.2011.01.030 – volume: 119 start-page: 3917 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0410 article-title: A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia publication-title: Blood doi: 10.1182/blood-2011-10-383406 – volume: 115 start-page: 1461 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0530 article-title: Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy publication-title: Blood doi: 10.1182/blood-2009-08-237412 – volume: 66 start-page: 2173 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0165 article-title: Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-3387 – volume: 71 start-page: 495 year: 2002 ident: 10.1016/j.canlet.2016.01.043_bib0300 article-title: Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine publication-title: J. Leukoc. Biol doi: 10.1189/jlb.71.3.495 – volume: 141 start-page: 39 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0080 article-title: Macrophage diversity enhances tumor progression and metastasis publication-title: Cell doi: 10.1016/j.cell.2010.03.014 – volume: 94 start-page: 715 year: 1998 ident: 10.1016/j.canlet.2016.01.043_bib0030 article-title: Tumor induction of VEGF promoter activity in stromal cells publication-title: Cell doi: 10.1016/S0092-8674(00)81731-6 – volume: 121 start-page: 335 year: 2005 ident: 10.1016/j.canlet.2016.01.043_bib0050 article-title: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion publication-title: Cell doi: 10.1016/j.cell.2005.02.034 – volume: 113 start-page: 6215 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0405 article-title: Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML publication-title: Blood doi: 10.1182/blood-2008-05-158311 – volume: 15 start-page: 669 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0175 article-title: Immunological hallmarks of stromal cells in the tumour microenvironment publication-title: Nat. Rev. Immunol doi: 10.1038/nri3902 – volume: 9 start-page: 1158 year: 2003 ident: 10.1016/j.canlet.2016.01.043_bib0305 article-title: Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia publication-title: Nat. Med doi: 10.1038/nm909 – volume: 62 start-page: 5019 year: 2002 ident: 10.1016/j.canlet.2016.01.043_bib0415 article-title: The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment publication-title: Cancer Res – volume: 6 start-page: 392 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0045 article-title: Fibroblasts in cancer publication-title: Nat. Rev. Cancer doi: 10.1038/nrc1877 – volume: 31 start-page: 760 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0500 article-title: Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer publication-title: Invest. New Drugs doi: 10.1007/s10637-012-9869-8 – volume: 95 start-page: 2630 year: 2000 ident: 10.1016/j.canlet.2016.01.043_bib0285 article-title: Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma publication-title: Blood doi: 10.1182/blood.V95.8.2630 – volume: 31 start-page: 51 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0590 article-title: Immunogenic cell death in cancer therapy publication-title: Annu. Rev. Immunol doi: 10.1146/annurev-immunol-032712-100008 – volume: 25 start-page: 2465 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0135 article-title: Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer publication-title: Genes Dev doi: 10.1101/gad.180331.111 – volume: 59 start-page: 267 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0200 article-title: Tumors induce the formation of suppressor endothelial cells in vivo publication-title: Cancer Immunol. Immunother doi: 10.1007/s00262-009-0747-y – volume: 66 start-page: 4349 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0125 article-title: Colony-stimulating factor-1 antibody reverses chemoresistance in human MCF-7 breast cancer xenografts publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-3523 – volume: 180 start-page: 1283 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0170 article-title: Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment publication-title: Am. J. Pathol doi: 10.1016/j.ajpath.2011.11.029 – volume: 21 start-page: 15 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0595 article-title: Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer publication-title: Cell Death Differ doi: 10.1038/cdd.2013.67 – volume: 18 start-page: 349 year: 2008 ident: 10.1016/j.canlet.2016.01.043_bib0090 article-title: Macrophage polarization in tumour progression publication-title: Semin. Cancer Biol doi: 10.1016/j.semcancer.2008.03.004 – volume: 33 start-page: 3812 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0370 article-title: Macrophages mediate gemcitabine resistance of pancreatic adenocarcinoma by upregulating cytidine deaminase publication-title: Oncogene doi: 10.1038/onc.2013.357 – volume: 21 start-page: 488 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0355 article-title: Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.02.017 – volume: 6 start-page: 237ra267 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0540 article-title: Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy publication-title: Sci. Transl. Med doi: 10.1126/scitranslmed.3007974 – volume: 88 start-page: 667 year: 1996 ident: 10.1016/j.canlet.2016.01.043_bib0180 article-title: Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium publication-title: Blood doi: 10.1182/blood.V88.2.667.bloodjournal882667 – volume: 25 start-page: 846 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0480 article-title: Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.05.016 – volume: 26 start-page: 623 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0360 article-title: Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells publication-title: Cancer Cell doi: 10.1016/j.ccell.2014.09.006 – volume: 125 start-page: 367 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0095 article-title: Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages publication-title: Int. J. Cancer doi: 10.1002/ijc.24401 – volume: 155 start-page: 438 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0445 article-title: The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications publication-title: Br. J. Haematol doi: 10.1111/j.1365-2141.2011.08864.x – volume: 6 start-page: 3085 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0295 article-title: Paracrine SDF-1alpha signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells publication-title: Oncotarget doi: 10.18632/oncotarget.3099 – volume: 71 start-page: 7463 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0545 article-title: PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-2449 – volume: 122 start-page: 35 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0440 article-title: HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment publication-title: Breast Cancer Res. Treat doi: 10.1007/s10549-009-0502-2 – volume: 94 start-page: 1823 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0040 article-title: Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature publication-title: Br. J. Cancer doi: 10.1038/sj.bjc.6603176 – volume: 53 start-page: 422 year: 2004 ident: 10.1016/j.canlet.2016.01.043_bib0575 article-title: Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D3 publication-title: Cancer Immunol. Immunother doi: 10.1007/s00262-003-0459-7 – volume: 13 start-page: 739 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0185 article-title: History of myeloid-derived suppressor cells publication-title: Nat. Rev. Cancer doi: 10.1038/nrc3581 – volume: 19 start-page: 1423 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0015 article-title: Microenvironmental regulation of tumor progression and metastasis publication-title: Nat. Med doi: 10.1038/nm.3394 – volume: 205 start-page: 1261 year: 2008 ident: 10.1016/j.canlet.2016.01.043_bib0100 article-title: “Re-educating” tumor-associated macrophages by targeting NF-kappaB publication-title: J. Exp. Med doi: 10.1084/jem.20080108 – volume: 116 start-page: 1955 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0335 article-title: Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake publication-title: J. Clin. Invest doi: 10.1172/JCI26532 – volume: 106 start-page: 1824 year: 2005 ident: 10.1016/j.canlet.2016.01.043_bib0400 article-title: Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells publication-title: Blood doi: 10.1182/blood-2004-12-4918 – volume: 4 start-page: 1094 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0035 article-title: Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis publication-title: J. Thorac. Oncol doi: 10.1097/JTO.0b013e3181a97e31 – volume: 123 start-page: 2395 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0245 article-title: CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia publication-title: J. Clin. Invest doi: 10.1172/JCI66553 – volume: 159 start-page: 2212 year: 1997 ident: 10.1016/j.canlet.2016.01.043_bib0255 article-title: IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade publication-title: J. Immunol doi: 10.4049/jimmunol.159.5.2212 – volume: 66 start-page: 1033 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0215 article-title: The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-3077 – volume: 117 start-page: 141 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0465 article-title: Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression publication-title: J. Neurooncol doi: 10.1007/s11060-014-1365-x – volume: 43 start-page: 2718 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0605 article-title: Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response publication-title: Eur. J. Immunol doi: 10.1002/eji.201242505 – volume: 71 start-page: 1041 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0495 article-title: A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors publication-title: Cancer Chemother. Pharmacol doi: 10.1007/s00280-013-2099-8 – volume: 70 start-page: 375 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0195 article-title: Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions publication-title: Hum. Immunol doi: 10.1016/j.humimm.2009.01.014 – volume: 121 start-page: 1814 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0455 article-title: Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy publication-title: Blood doi: 10.1182/blood-2012-01-406272 – volume: 437 start-page: 397 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0065 article-title: Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors publication-title: Biochem. Biophys. Res. Commun doi: 10.1016/j.bbrc.2013.06.089 – volume: 39 start-page: 211 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0600 article-title: Autophagy and cellular immune responses publication-title: Immunity doi: 10.1016/j.immuni.2013.07.017 – volume: 31 start-page: 669 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0430 article-title: A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer publication-title: Invest. New Drugs doi: 10.1007/s10637-012-9857-z – volume: 108 start-page: 12425 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0365 article-title: Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1106645108 – volume: 60 start-page: 2497 year: 2000 ident: 10.1016/j.canlet.2016.01.043_bib0220 article-title: Role of extracellular matrix assembly in interstitial transport in solid tumors publication-title: Cancer Res – volume: 450 start-page: 825 year: 2007 ident: 10.1016/j.canlet.2016.01.043_bib0385 article-title: Bv8 regulates myeloid-cell-dependent tumour angiogenesis publication-title: Nature doi: 10.1038/nature06348 – volume: 286 start-page: 6801 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0345 article-title: The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts publication-title: J. Biol. Chem doi: 10.1074/jbc.M110.168617 – volume: 229 start-page: 176 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0105 article-title: Macrophage plasticity and polarization in tissue repair and remodelling publication-title: J. Pathol doi: 10.1002/path.4133 – volume: 25 start-page: 198 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0350 article-title: Microenvironmental regulation of therapeutic response in cancer publication-title: Trends Cell Biol doi: 10.1016/j.tcb.2014.11.006 – volume: 19 start-page: 6286 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0520 article-title: A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma publication-title: Clin. Cancer Res doi: 10.1158/1078-0432.CCR-13-1320 – volume: 26 start-page: 405 year: 2005 ident: 10.1016/j.canlet.2016.01.043_bib0325 article-title: Role of the extracellular matrix proteins in the resistance of SP6.5 uveal melanoma cells toward cisplatin publication-title: Int. J. Oncol – volume: 106 start-page: 6742 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0145 article-title: G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0902280106 – volume: 33 start-page: 3117 year: 2003 ident: 10.1016/j.canlet.2016.01.043_bib0190 article-title: Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis publication-title: Eur. J. Immunol doi: 10.1002/eji.200324270 – volume: 144 start-page: 646 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0020 article-title: Hallmarks of cancer: the next generation publication-title: Cell doi: 10.1016/j.cell.2011.02.013 – volume: 99 start-page: 1441 year: 2007 ident: 10.1016/j.canlet.2016.01.043_bib0025 article-title: Drug resistance and the solid tumor microenvironment publication-title: J. Natl. Cancer Inst doi: 10.1093/jnci/djm135 – volume: 13 start-page: 874 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0250 article-title: Lymph node stromal cells enhance drug-resistant colon cancer cell tumor formation through SDF-1alpha/CXCR4 paracrine signaling publication-title: Neoplasia doi: 10.1593/neo.11324 – volume: 132 start-page: 455 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0450 article-title: Inhibition of alpha4beta1 integrin increases ovarian cancer response to carboplatin publication-title: Gynecol. Oncol doi: 10.1016/j.ygyno.2013.12.031 – volume: 8 start-page: 1231 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0490 article-title: Enhancement of paclitaxel and carboplatin therapies by CCL2 blockade in ovarian cancers publication-title: Mol. Oncol doi: 10.1016/j.molonc.2014.03.016 – volume: 209 start-page: 139 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0210 article-title: Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor publication-title: J. Endocrinol doi: 10.1530/JOE-10-0377 – volume: 42 start-page: 2060 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0535 article-title: Anti-IL-6 receptor mAb eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T-cell responses publication-title: Eur. J. Immunol doi: 10.1002/eji.201142335 – volume: 150 start-page: 165 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0150 article-title: A CXCL1 paracrine network links cancer chemoresistance and metastasis publication-title: Cell doi: 10.1016/j.cell.2012.04.042 – volume: 68 start-page: 4398 year: 2008 ident: 10.1016/j.canlet.2016.01.043_bib0435 article-title: Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-6390 – volume: 30 start-page: 749 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0460 article-title: Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium publication-title: Invest. New Drugs doi: 10.1007/s10637-010-9573-5 – volume: 101 start-page: 2775 year: 2003 ident: 10.1016/j.canlet.2016.01.043_bib0290 article-title: Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma publication-title: Blood doi: 10.1182/blood-2002-09-2907 – volume: 20 start-page: 676 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0550 article-title: Generation of a new therapeutic peptide that depletes myeloid-derived suppressor cells in tumor-bearing mice publication-title: Nat. Med doi: 10.1038/nm.3560 – volume: 10 start-page: 111 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0505 article-title: Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study publication-title: Target. Oncol doi: 10.1007/s11523-014-0320-2 – volume: 36 start-page: 229 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0085 article-title: Macrophages and cancer: from mechanisms to therapeutic implications publication-title: Trends Immunol doi: 10.1016/j.it.2015.02.004 – volume: 106 start-page: 1012 year: 2005 ident: 10.1016/j.canlet.2016.01.043_bib0240 article-title: Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha publication-title: Blood doi: 10.1182/blood-2004-03-0889 – volume: 487 start-page: 500 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0070 article-title: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion publication-title: Nature doi: 10.1038/nature11183 – volume: 15 start-page: 1100 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0475 article-title: Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial publication-title: Lancet Oncol doi: 10.1016/S1470-2045(14)70379-1 – volume: 8 start-page: 1461 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0060 article-title: On the origin of cancer-associated fibroblasts publication-title: Cell Cycle doi: 10.4161/cc.8.10.8557 – volume: 13 start-page: 1776 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0310 article-title: ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4401849 – volume: 19 start-page: 1114 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0390 article-title: An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy publication-title: Nat. Med doi: 10.1038/nm.3291 – volume: 15 start-page: 1079 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0380 article-title: Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma publication-title: Neuro Oncol doi: 10.1093/neuonc/not082 – volume: 203 start-page: 2691 year: 2006 ident: 10.1016/j.canlet.2016.01.043_bib0560 article-title: Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function publication-title: J. Exp. Med doi: 10.1084/jem.20061104 – volume: 212 start-page: 435 year: 2015 ident: 10.1016/j.canlet.2016.01.043_bib0120 article-title: The interaction of anticancer therapies with tumor-associated macrophages publication-title: J. Exp. Med doi: 10.1084/jem.20150295 – volume: 1 start-page: 54 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0110 article-title: Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy publication-title: Cancer Discov doi: 10.1158/2159-8274.CD-10-0028 – volume: 67 start-page: 11021 year: 2007 ident: 10.1016/j.canlet.2016.01.043_bib0570 article-title: Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-07-2593 – volume: 94 start-page: 1785 year: 1997 ident: 10.1016/j.canlet.2016.01.043_bib0225 article-title: Direct in vivo measurement of targeted binding in a human tumor xenograft publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.94.5.1785 – volume: 21 start-page: 822 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0525 article-title: Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.04.025 – volume: 316 start-page: 2713 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0055 article-title: Activation of fibroblasts in cancer stroma publication-title: Exp. Cell Res doi: 10.1016/j.yexcr.2010.04.032 – volume: 88 start-page: 268 year: 1994 ident: 10.1016/j.canlet.2016.01.043_bib0275 article-title: Interferon-alpha up-regulates bcl-2 expression and protects B-CLL cells from apoptosis in vitro and in vivo publication-title: Br. J. Haematol doi: 10.1111/j.1365-2141.1994.tb05017.x – volume: 11 start-page: 258 year: 1997 ident: 10.1016/j.canlet.2016.01.043_bib0280 article-title: Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis publication-title: Leukemia doi: 10.1038/sj.leu.2400556 – volume: 67 start-page: 7477 year: 2007 ident: 10.1016/j.canlet.2016.01.043_bib0585 article-title: A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-06-4639 – volume: 98 start-page: 428 year: 2001 ident: 10.1016/j.canlet.2016.01.043_bib0260 article-title: Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration publication-title: Blood doi: 10.1182/blood.V98.2.428 – volume: 116 start-page: 1526 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0470 article-title: A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + or − dacarbazine in patients with stage IV metastatic melanoma publication-title: Cancer doi: 10.1002/cncr.24821 – volume: 16 start-page: 1812 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0565 article-title: Anti-inflammatory triterpenoid blocks immune suppressive function of MDSCs and improves immune response in cancer publication-title: Clin. Cancer Res doi: 10.1158/1078-0432.CCR-09-3272 – volume: 176 start-page: 1319 year: 1992 ident: 10.1016/j.canlet.2016.01.043_bib0270 article-title: Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression publication-title: J. Exp. Med doi: 10.1084/jem.176.5.1319 – volume: 99 start-page: 4138 year: 2002 ident: 10.1016/j.canlet.2016.01.043_bib0265 article-title: Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk publication-title: Blood doi: 10.1182/blood.V99.11.4138 – volume: 29 start-page: 6115 year: 2010 ident: 10.1016/j.canlet.2016.01.043_bib0320 article-title: Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population publication-title: Oncogene doi: 10.1038/onc.2010.350 – volume: 12 start-page: 253 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0140 article-title: Coordinated regulation of myeloid cells by tumours publication-title: Nat. Rev. Immunol doi: 10.1038/nri3175 – volume: 85 start-page: 1033 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0075 article-title: Fibroblast-mediated drug resistance in cancer publication-title: Biochem. Pharmacol doi: 10.1016/j.bcp.2013.01.018 – volume: 3 start-page: 377 year: 2003 ident: 10.1016/j.canlet.2016.01.043_bib0330 article-title: Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00058-8 – volume: 71 start-page: 2664 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0555 article-title: COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-3055 – volume: 21 start-page: 309 year: 2012 ident: 10.1016/j.canlet.2016.01.043_bib0010 article-title: Accessories to the crime: functions of cells recruited to the tumor microenvironment publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.02.022 – volume: 278 start-page: 25285 year: 2003 ident: 10.1016/j.canlet.2016.01.043_bib0340 article-title: Regulation of multidrug resistance in cancer cells by hyaluronan publication-title: J. Biol. Chem doi: 10.1074/jbc.C300173200 – volume: 25 start-page: 911 year: 2007 ident: 10.1016/j.canlet.2016.01.043_bib0130 article-title: Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells publication-title: Nat. Biotechnol doi: 10.1038/nbt1323 – volume: 19 start-page: 1264 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0510 article-title: CSF-1R inhibition alters macrophage polarization and blocks glioma progression publication-title: Nat. Med doi: 10.1038/nm.3337 – volume: 156 start-page: 590 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0610 article-title: Sensitizing protective tumor microenvironments to antibody-mediated therapy publication-title: Cell doi: 10.1016/j.cell.2013.12.041 – volume: 15 start-page: 520 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0420 article-title: Bortezomib, dexamethasone, and fibroblast growth factor receptor 3-specific tyrosine kinase inhibitor in t(4;14) myeloma publication-title: Clin. Cancer Res doi: 10.1158/1078-0432.CCR-08-1612 – volume: 331 start-page: 1612 year: 2011 ident: 10.1016/j.canlet.2016.01.043_bib0515 article-title: CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans publication-title: Science doi: 10.1126/science.1198443 – volume: 62 start-page: 909 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0580 article-title: Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer publication-title: Cancer Immunol. Immunother doi: 10.1007/s00262-013-1396-8 – volume: 20 start-page: 4995 year: 2001 ident: 10.1016/j.canlet.2016.01.043_bib0315 article-title: Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells publication-title: Oncogene doi: 10.1038/sj.onc.1204554 – volume: 5 start-page: 2208 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0375 article-title: Anti-vascular endothelial growth factor therapy-induced glioma invasion is associated with accumulation of Tie2-expressing monocytes publication-title: Oncotarget doi: 10.18632/oncotarget.1893 – volume: 9 start-page: 665 year: 2009 ident: 10.1016/j.canlet.2016.01.043_bib0230 article-title: Environment-mediated drug resistance: a major contributor to minimal residual disease publication-title: Nat. Rev. Cancer doi: 10.1038/nrc2714 – volume: 9 start-page: 974 year: 2014 ident: 10.1016/j.canlet.2016.01.043_bib0425 article-title: Antitumor efficacy of the anti-interleukin-6 (IL-6) antibody siltuximab in mouse xenograft models of lung cancer publication-title: J. Thorac. Oncol doi: 10.1097/JTO.0000000000000193 – volume: 73 start-page: 2480 year: 2013 ident: 10.1016/j.canlet.2016.01.043_bib0115 article-title: Chemotherapy alters monocyte differentiation to favor generation of cancer-supporting M2 macrophages in the tumor microenvironment publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-3542 – volume: 96 start-page: 2655 year: 2000 ident: 10.1016/j.canlet.2016.01.043_bib0235 article-title: Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1 publication-title: Blood doi: 10.1182/blood.V96.8.2655 |
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| Snippet | •Tumor microenvironment (TME) influences therapeutic response and clinical outcome.•TME mediated resistance results from continuous crosstalk between tumor... Highlights • Tumor microenvironment (TME) influences therapeutic response and clinical outcome. • TME mediated resistance results from continuous crosstalk... The tumor microenvironment significantly influences therapeutic response and clinical outcome. Microenvironment-mediated drug resistance can be induced by... |
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| SubjectTerms | Angiogenesis Animals Antineoplastic Agents - therapeutic use Apoptosis Bone marrow Cancer Cancer therapies Conflicts of interest Cytokines Dendritic cells Drug resistance Extracellular matrix Fibroblasts Gene expression Hematology, Oncology and Palliative Medicine Humans Hypoxia Immunotherapy Medical prognosis Metastasis Microenvironment Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Resistance Substance abuse treatment Target therapy Tumor Microenvironment - drug effects Tumorigenesis Tumors Vascular endothelial growth factor |
| Title | Tumor microenvironment and therapeutic response |
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