Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

The cytokine-induced SH2-containing protein CIS belongs to the suppressor of cytokine signaling (SOCS) protein family. Here, we show the critical role of CIS in suppressing natural killer (NK) cell control of tumor initiation and metastasis. Cish-deficient mice were highly resistant to methylcholant...

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Bibliographic Details

Published in:	Oncoimmunology Vol. 6; no. 2; p. e1267892
Main Authors:	Putz, Eva M., Guillerey, Camille, Kos, Kevin, Stannard, Kimberley, Miles, Kim, Delconte, Rebecca B., Takeda, Kazuyoshi, Nicholson, Sandra E., Huntington, Nicholas D., Smyth, Mark J.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.02.2017 Taylor & Francis Group
Subjects:	Cancer cytokine signaling immunotherapy metastasis NK cells Original Research cytokine signaling NK cells metastasis immunotherapy Cancer
ISSN:	2162-402X, 2162-4011, 2162-402X
Online Access:	Get full text
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