Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia

Interleukin-7 receptor α (encoded by IL7R ) is essential for lymphoid development. Whether acute lymphoblastic leukemia (ALL)-related IL7R gain-of-function mutations can trigger leukemogenesis remains unclear. Here, we demonstrate that lymphoid-restricted mutant IL7R , expressed at physiological lev...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 7268 - 16
Main Authors:	Almeida, Afonso R. M., Neto, João L., Cachucho, Ana, Euzébio, Mayara, Meng, Xiangyu, Kim, Rathana, Fernandes, Marta B., Raposo, Beatriz, Oliveira, Mariana L., Ribeiro, Daniel, Fragoso, Rita, Zenatti, Priscila P., Soares, Tiago, de Matos, Mafalda R., Corrêa, Juliana Ronchi, Duque, Mafalda, Roberts, Kathryn G., Gu, Zhaohui, Qu, Chunxu, Pereira, Clara, Pyne, Susan, Pyne, Nigel J., Barreto, Vasco M., Bernard-Pierrot, Isabelle, Clappier, Emannuelle, Mullighan, Charles G., Grosso, Ana R., Yunes, J. Andrés, Barata, João T.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 14.12.2021 Nature Publishing Group Nature Portfolio
Subjects:	1-Phosphatidylinositol 3-kinase 13/31 13/95 38 38/77 38/91 42/44 45 631/67/1990/283/2125 631/67/395 631/67/70 64/110 692/4017 692/4028/67/1990/283/2125 82/58 Acute lymphoblastic leukemia Animal models Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - genetics Cell viability Cytokines Gain of Function Mutation Heterozygote Homozygote Humanities and Social Sciences Humans Interleukin 7 Interleukin 7 receptors Interleukin-7 Receptor alpha Subunit - genetics Interleukin-7 Receptor alpha Subunit - metabolism Kinases Leukemia Leukemogenesis Life Sciences Lymphatic leukemia Lymphocytes B Malignancy Mice multidisciplinary Mutants Mutation Myc protein Pax5 protein Penetrance Precancerous Conditions - genetics Precancerous Conditions - pathology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Precursor Cells, B-Lymphoid - pathology Precursors Proto-Oncogene Proteins p21(ras) - genetics Receptors Science Science (multidisciplinary) Signal Transduction - drug effects Signaling Stat5 protein Subgroups Suppressors TOR protein Transcription Tumors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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