Pan-genomic analysis of bovine monocyte-derived macrophage gene expression in response to in vitro infection with Mycobacterium avium subspecies paratuberculosis

Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infecti...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Veterinary research (Paris) Ročník 43; číslo 1; s. 25 - 158
Hlavní autoři: MacHugh, David E, Taraktsoglou, Maria, Killick, Kate E, Nalpas, Nicolas C, Browne, John A, DE Park, Stephen, Hokamp, Karsten, Gormley, Eamonn, Magee, David A
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 28.03.2012
BioMed Central Ltd
BMC
Témata:
Animals
apoptosis
Cattle
digestive system diseases
Female
females
gene expression
Gene Expression Profiling - veterinary
Gene Expression Regulation
Genes
Genetic aspects
Health aspects
Host-Pathogen Interactions
host-pathogen relationships
hosts
Immunology
immunopathology
Johne's disease
Macrophages
Macrophages - immunology
Macrophages - microbiology
Medicine
Medicine & Public Health
Microbiology
Mycobacterium avium
Mycobacterium avium subsp. paratuberculosis - physiology
Oligonucleotide Array Sequence Analysis - veterinary
paratuberculosis
Paratuberculosis - genetics
Paratuberculosis - immunology
Paratuberculosis - microbiology
Physiological aspects
Polymerase Chain Reaction - veterinary
Risk factors
systems analysis
Time Factors
transcription (genetics)
transcriptome
transcriptomics
Veterinary Medicine/Veterinary Science
Virology
Ireland
Paratuberculosis Infection
Mycobacterial Infection
Mycobacterium Avium Subspecies Paratuberculosis
Bovine Genome Array
Cytosolic PRRs
ISSN:1297-9716, 0928-4249, 1297-9716
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne’s disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P -value threshold ≤ 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.
AbstractList Abstract Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne’s disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P-value threshold ≤ 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne’s disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P-value threshold ≤ 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne?s disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne?s disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P-value threshold [less than or equal to] 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne’s disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P -value threshold ≤ 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne's disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne's disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P-value threshold ≤ 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne's disease, an intestinal disease of ruminants with major economic consequences. Infectious bacilli are phagocytosed by host macrophages upon exposure where they persist, resulting in lengthy subclinical phases of infection that can lead to immunopathology and disease dissemination. Consequently, analysis of the macrophage transcriptome in response to M. avium subsp. paratuberculosis infection can provide valuable insights into the molecular mechanisms that underlie Johne's disease. Here, we investigate pan-genomic gene expression in bovine monocyte-derived macrophages (MDM) purified from seven age-matched females, in response to in vitro infection with M. avium subsp. paratuberculosis (multiplicity of infection 2:1) at intervals of 2 hours, 6 hours and 24 hours post-infection (hpi). Differentially expressed genes were identified by comparing the transcriptomes of the infected MDM to the non-infected control MDM at each time point (adjusted P-value threshold ≤ 0.10). 1050 differentially expressed unique genes were identified 2 hpi, with 974 and 78 differentially expressed unique genes detected 6 and 24 hpi, respectively. Furthermore, in the infected MDM the number of upregulated genes exceeded the number of downregulated genes at each time point, with the fold-change in expression for the upregulated genes markedly higher than that for the downregulated genes. Inspection and systems biology analysis of the differentially expressed genes revealed an enrichment of genes involved in the inflammatory response, cell signalling pathways and apoptosis. The transcriptional changes associated with cellular signalling and the inflammatory response may reflect different immuno-modulatory mechanisms that underlie host-pathogen interactions during infection.
ArticleNumber 25
Audience Academic
Author Hokamp, Karsten
Magee, David A
DE Park, Stephen
Browne, John A
Killick, Kate E
MacHugh, David E
Nalpas, Nicolas C
Taraktsoglou, Maria
Gormley, Eamonn
AuthorAffiliation 2 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
4 Tuberculosis Diagnostics and Immunology Research Centre, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
3 Smurfit Institute of Genetics, Trinity College Dublin, Trinity College, Belfield, Dublin 2, Ireland
1 Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland
AuthorAffiliation_xml – name: 2 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
– name: 3 Smurfit Institute of Genetics, Trinity College Dublin, Trinity College, Belfield, Dublin 2, Ireland
– name: 1 Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin, Belfield, Dublin 4, Ireland
– name: 4 Tuberculosis Diagnostics and Immunology Research Centre, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland
Author_xml – sequence: 1
  givenname: David E
  surname: MacHugh
  fullname: MacHugh, David E
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin
– sequence: 2
  givenname: Maria
  surname: Taraktsoglou
  fullname: Taraktsoglou, Maria
  email: maria.taraktsoglou@hse.gsi.gov.uk
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin
– sequence: 3
  givenname: Kate E
  surname: Killick
  fullname: Killick, Kate E
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin
– sequence: 4
  givenname: Nicolas C
  surname: Nalpas
  fullname: Nalpas, Nicolas C
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin
– sequence: 5
  givenname: John A
  surname: Browne
  fullname: Browne, John A
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin
– sequence: 6
  givenname: Stephen
  surname: DE Park
  fullname: DE Park, Stephen
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin
– sequence: 7
  givenname: Karsten
  surname: Hokamp
  fullname: Hokamp, Karsten
  organization: Smurfit Institute of Genetics, Trinity College Dublin, Trinity College
– sequence: 8
  givenname: Eamonn
  surname: Gormley
  fullname: Gormley, Eamonn
  organization: Tuberculosis Diagnostics and Immunology Research Centre, UCD School of Veterinary Medicine, University College Dublin
– sequence: 9
  givenname: David A
  surname: Magee
  fullname: Magee, David A
  email: david.magee@ucd.ie
  organization: Animal Genomics Laboratory, UCD School of Agriculture and Food Science, University College Dublin
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22455317$$D View this record in MEDLINE/PubMed
BookMark eNqFkktv1DAUhSNURB-wZocssWGT1nb8SDZIVcWjUhEsYG059s2Mq8QOdjJlfg7_FIcpow7ioUjJzfV3jn3lc1oc-eChKJ4TfE5ILS4IbWTZSCJKVpWUPypO9p2jB_VxcZrSLcZEVJw9KY4pZZxXRJ4U3z9pX67Ah8EZpL3ut8klFDrUho3zgIbgg9lOUFqIbgMWDdrEMK71ClCWAYJvY4SUXPDIeZTLMfgEaArL78ZNcSk6MNNC3LlpjT5sTWi1mbLhPCC9Wd5pbtMIxkFCo456mluIZu5DPszT4nGn-wTP7r9nxZe3bz5fvS9vPr67vrq8KY3AeCoNthp3krbWSsYYYAm85tZ2jNq6kzUntdS0ZaLVdVOJ2rCqpmAoJqTVUovqrLje-dqgb9UY3aDjVgXt1M9GiCul4-RMD8rUlZSgG7AtY9LSxnaNaKHCnFlBoM1er3de49wOYA34Ker-wPRwxbu1WoWNqhghjPFs8OreIIavM6RJDS4Z6HvtIcxJZUhQKQit_4_iigqCOacZfblDVzpPka8l5M3NgqtL2tQc10LgTJ3_gcqPhRySnL_O5f6B4MXDafdj_kpZBi52QI5OShG6PUKwWnKslqSqJamKVYou8_PfFMZNeslQPovr_6HDO13KO_gVRHUb5phjnf4q-QE74wi4
CitedBy_id crossref_primary_10_1016_S2095_3119_21_63644_4
crossref_primary_10_1186_s12863_015_0247_3
crossref_primary_10_1111_jav_02734
crossref_primary_10_3389_fvets_2022_974444
crossref_primary_10_1371_journal_pone_0138770
crossref_primary_10_1093_jas_sky261
crossref_primary_10_1186_s12859_016_0971_3
crossref_primary_10_1186_s12864_021_07487_4
crossref_primary_10_1371_journal_pntd_0012882
crossref_primary_10_1186_1471_2164_14_230
crossref_primary_10_1186_s12863_024_01234_w
crossref_primary_10_3389_fimmu_2014_00536
crossref_primary_10_3389_fimmu_2015_00023
crossref_primary_10_3389_fimmu_2019_02874
crossref_primary_10_1016_j_vetimm_2015_10_009
crossref_primary_10_1093_femspd_ftv085
crossref_primary_10_1186_s13567_014_0096_5
crossref_primary_10_1371_journal_pone_0071502
crossref_primary_10_1016_j_tvjl_2017_02_007
crossref_primary_10_3390_vetsci6040080
crossref_primary_10_3168_jds_2015_9573
crossref_primary_10_1016_j_mimet_2019_105779
crossref_primary_10_1186_1471_2164_15_58
crossref_primary_10_1038_srep46695
crossref_primary_10_1016_j_prevetmed_2015_08_011
crossref_primary_10_1111_jpn_12968
crossref_primary_10_3389_fmicb_2022_1041314
crossref_primary_10_1111_pim_12779
crossref_primary_10_1016_j_dci_2013_02_004
crossref_primary_10_1016_j_molimm_2017_08_017
crossref_primary_10_1155_2013_908348
crossref_primary_10_3389_fgene_2021_668448
crossref_primary_10_1038_s41598_018_38141_x
crossref_primary_10_1038_srep24964
crossref_primary_10_1111_j_1600_048X_2011_05860_x
crossref_primary_10_3390_ncrna10040038
crossref_primary_10_1038_srep31014
crossref_primary_10_3390_ijms20112708
crossref_primary_10_1016_j_mito_2015_05_005
crossref_primary_10_1371_journal_pone_0104238
crossref_primary_10_1371_journal_pone_0153932
crossref_primary_10_3390_ani11020468
crossref_primary_10_1186_s13567_015_0185_0
crossref_primary_10_3389_fmicb_2021_796922
crossref_primary_10_1002_jcp_26942
crossref_primary_10_1016_j_vetimm_2020_110131
crossref_primary_10_1016_j_vetimm_2014_04_006
Cites_doi 10.1016/j.imbio.2008.07.009
10.2460/ajvr.69.6.804
10.1038/nrmicro2387
10.4049/jimmunol.156.6.2119
10.1016/j.tube.2011.07.002
10.1016/j.cytogfr.2011.02.001
10.1128/IAI.70.9.4961-4967.2002
10.2460/javma.1989.194.10.1423
10.3168/jds.S0022-0302(98)75577-8
10.1016/S0065-2660(07)00412-9
10.1155/2011/405310
10.1007/s00018-007-7012-3
10.1038/ng1201-365
10.1002/bies.20815
10.1038/mi.2011.3
10.1016/j.micinf.2008.02.005
10.1111/j.1600-065X.2010.00995.x
10.2460/ajvr.68.6.625
10.1093/bioinformatics/btm478
10.1016/S0898-6568(02)00075-X
10.1128/IAI.00614-07
10.1016/j.prevetmed.2008.07.003
10.1073/pnas.0807694106
10.1093/nar/gkr1184
10.1038/nm906
10.1128/iai.65.1.298-304.1997
10.1152/physiolgenomics.00098.2006
10.1016/j.vetimm.2010.12.002
10.1016/S0167-5877(99)00037-9
10.1016/S0076-6879(06)11019-8
10.1038/emboj.2008.31
10.1016/j.vetmic.2007.12.011
10.2460/ajvr.1995.56.10.1322
10.1016/j.cell.2004.11.038
10.2460/ajvr.2005.66.721
10.2202/1544-6115.1027
10.1038/ni.1863
10.1177/030098588802500205
10.1038/nri2161
10.1111/j.2517-6161.1995.tb02031.x
10.1093/bioinformatics/btl033
10.1016/0165-2427(93)90075-F
10.1128/IAI.70.10.5494-5502.2002
10.1186/gb-2007-8-2-r19
10.1016/j.febslet.2008.01.007
10.1093/nar/gkm306
10.4049/jimmunol.167.6.3339
10.1007/978-1-60761-247-6_13
10.1079/AHRR200134
10.1111/j.1365-2567.2004.01812.x
10.1111/j.1600-065X.2010.00984.x
10.1251/bpo126
10.1016/j.vetimm.2008.10.294
10.1186/1471-2164-12-611
10.1093/bfgp/elq009
10.1002/jlb.67.1.2
10.1371/journal.pone.0001403
10.1165/rcmb.2008-0219OC
10.1038/nrmicro840
10.1016/j.immuni.2011.05.003
10.1084/jem.183.5.2293
10.1186/1471-2164-8-400
10.1111/j.1365-2249.2006.03053.x
10.1016/j.dci.2011.01.001
10.1371/journal.ppat.1000665
10.1128/IAI.72.6.3089-3096.2004
10.1038/nrmicro2321
10.1093/bioinformatics/bti605
10.1371/journal.ppat.1000234
10.1186/gb-2004-5-10-r80
10.1007/978-1-61737-954-3_2
10.1126/science.1085536
10.3389/fmicb.2011.00002
ContentType Journal Article
Copyright MacHugh et al; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
COPYRIGHT 2012 BioMed Central Ltd.
Copyright ©2012 MacHugh et al; licensee BioMed Central Ltd. 2012 MacHugh et al; licensee BioMed Central Ltd.
Copyright_xml – notice: MacHugh et al; licensee BioMed Central Ltd. 2012 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
– notice: COPYRIGHT 2012 BioMed Central Ltd.
– notice: Copyright ©2012 MacHugh et al; licensee BioMed Central Ltd. 2012 MacHugh et al; licensee BioMed Central Ltd.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
DOA
DOI 10.1186/1297-9716-43-25
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList
AGRICOLA
CrossRef



MEDLINE - Academic
MEDLINE
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals (DOAJ)
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Veterinary Medicine
EISSN 1297-9716
EndPage 158
ExternalDocumentID oai_doaj_org_article_c8377ea9edb447d29df96be3054d61eb
PMC3411445
A298508660
22455317
10_1186_1297_9716_43_25
Genre Research Support, U.S. Gov't, Non-P.H.S
Research Support, U.S. Gov't, P.H.S
Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations Ireland
GeographicLocations_xml – name: Ireland
GroupedDBID ---
0R~
123
2VQ
2WC
4.4
53G
5VS
AAFWJ
AAHBH
AAJSJ
AASML
ACGFS
ACGOD
ADBBV
ADRAZ
ADUKV
AENEX
AFPKN
AHBYD
AHMBA
AHSBF
AHYZX
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AOIJS
BAWUL
BCNDV
BFQNJ
BMC
C6C
CS3
DIK
DU5
E3Z
EBLON
EBS
EJD
F5P
FRP
FYUFA
GROUPED_DOAJ
H13
HYE
IAG
IAO
INH
INR
IPNFZ
ITC
KQ8
M41
M48
O5R
O5S
OK1
PGMZT
RBZ
RED
RIG
RNS
ROL
RPM
RSV
SMD
SOJ
AAYXX
CITATION
ALIPV
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
5PM
ID FETCH-LOGICAL-c600t-c0da0f72bdd7444e07e585ddf42d8f785187a2b46ba89368c4382ec2011ba7a63
IEDL.DBID RSV
ISICitedReferencesCount 52
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000307291600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 1297-9716
0928-4249
IngestDate Fri Oct 03 12:49:21 EDT 2025
Tue Sep 30 16:42:29 EDT 2025
Sun Nov 09 13:49:49 EST 2025
Fri Sep 05 12:09:45 EDT 2025
Mon Oct 20 22:37:42 EDT 2025
Mon Oct 20 16:08:21 EDT 2025
Thu Apr 03 07:05:35 EDT 2025
Sat Nov 29 08:06:09 EST 2025
Tue Nov 18 22:18:57 EST 2025
Sat Sep 06 07:20:49 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Paratuberculosis Infection
Mycobacterial Infection
Mycobacterium Avium Subspecies Paratuberculosis
Bovine Genome Array
Cytosolic PRRs
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c600t-c0da0f72bdd7444e07e585ddf42d8f785187a2b46ba89368c4382ec2011ba7a63
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://link.springer.com/10.1186/1297-9716-43-25
PMID 22455317
PQID 1032610552
PQPubID 23479
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_c8377ea9edb447d29df96be3054d61eb
pubmedcentral_primary_oai_pubmedcentral_nih_gov_3411445
proquest_miscellaneous_1446276128
proquest_miscellaneous_1032610552
gale_infotracmisc_A298508660
gale_infotracacademiconefile_A298508660
pubmed_primary_22455317
crossref_primary_10_1186_1297_9716_43_25
crossref_citationtrail_10_1186_1297_9716_43_25
springer_journals_10_1186_1297_9716_43_25
PublicationCentury 2000
PublicationDate 2012-03-28
PublicationDateYYYYMMDD 2012-03-28
PublicationDate_xml – month: 03
  year: 2012
  text: 2012-03-28
  day: 28
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Veterinary research (Paris)
PublicationTitleAbbrev Vet Res
PublicationTitleAlternate Vet Res
PublicationYear 2012
Publisher BioMed Central
BioMed Central Ltd
BMC
Publisher_xml – name: BioMed Central
– name: BioMed Central Ltd
– name: BMC
References SS Nielsen (158_CR6) 2009; 88
JR Stabel (158_CR28) 2011; 18
W Talloen (158_CR34) 2007; 23
CD Souza (158_CR73) 2007; 9
CD Souza (158_CR20) 2008; 44
M Taraktsoglou (158_CR27) 2011; 140
JR Stabel (158_CR7) 1998; 81
K Over (158_CR2) 2011; 37
MC Tal (158_CR87) 2009; 106
SS Nielsen (158_CR5) 2008; 129
YL Zhang (158_CR71) 2005; 2
DA Magee (158_CR43) 1996; 183
M Florido (158_CR95) 2004; 111
UE Schaible (158_CR80) 2003; 9
J Hellemans (158_CR41) 2007; 8
DJ Weiss (158_CR60) 2002; 70
S Nicholson (158_CR42) 1996; 183
RF Silver (158_CR51) 2009; 40
M Yu (158_CR85) 2011; 22
S Widdison (158_CR50) 2011; 35
SJ Sasindran (158_CR65) 2011; 2
KG Meade (158_CR55) 2007; 8
GM Barton (158_CR69) 2003; 300
N Reiling (158_CR74) 2001; 167
ES Pierce (158_CR10) 2009; 5
SM Behar (158_CR78) 2011; 4
JB Singer (158_CR48) 2009; 573
J Keane (158_CR79) 1997; 65
A Koul (158_CR58) 2004; 2
PM Coussens (158_CR17) 2004; 72
DG Russell (158_CR84) 2011; 240
T Kawai (158_CR68) 2010; 11
VJ Timms (158_CR4) 2011; 85
A Tiwari (158_CR19) 2006; 47
EW Sayers (158_CR44) 2012; 40
SL Ott (158_CR8) 1999; 40
DJ Weiss (158_CR15) 2008; 45
PM Coussens (158_CR25) 2002; 70
Y Benjamini (158_CR37) 1995; 57
B Levine (158_CR90) 2007; 7
S Hochreiter (158_CR33) 2006; 22
JT Murphy (158_CR24) 2006; 28
T Basler (158_CR53) 2008; 213
RM Watanabe (158_CR47) 2011; 700
J Kleinnijenhuis (158_CR64) 2011; 2011
MF Romano (158_CR75) 1996; 156
MG Gutierrez (158_CR89) 2004; 119
S Sommer (158_CR94) 2009; 128
CN Jacobsen (158_CR26) 1993; 39
A Brazma (158_CR38) 2001; 29
CL Wilson (158_CR32) 2005; 21
GK Smyth (158_CR35) 2004; 3
V Deretic (158_CR91) 2011; 240
BC Tooker (158_CR21) 2002; 87
E Kabara (158_CR23) 2010; 9
S Widdison (158_CR83) 2006; 144
JJ Haddad (158_CR76) 2003; 15
E Lesho (158_CR56) 2011; 91
PM Coussens (158_CR13) 2004; 72
KM Monroe (158_CR92) 2009; 5
M Safran (158_CR45) 2010; 2010
CV Harding (158_CR63) 2010; 8
MA Delgado (158_CR88) 2008; 27
E Momotani (158_CR14) 1988; 25
PM Coussens (158_CR54) 2003; 71
E Elass (158_CR77) 2008; 582
L Tailleux (158_CR52) 2008; 3
A Blumenthal (158_CR72) 2002; 70
SM Behar (158_CR81) 2010; 8
National Research Council (USA) Committee on Diagnosis and Control of Johne's Disease (158_CR3) 2003
SE Seitz (158_CR12) 1989; 194
JS Morey (158_CR46) 2006; 8
Y Zhang (158_CR70) 2007; 64
S Józefowski (158_CR59) 2008; 30
RN Streeter (158_CR11) 1995; 56
K Nalubamba (158_CR62) 2008; 10
158_CR29
C van Kooten (158_CR93) 2000; 67
T Barrett (158_CR39) 2006; 411
YM Loo (158_CR86) 2011; 34
JR Stabel (158_CR9) 1998; 81
SL McKenna (158_CR18) 2006; 47
CP Verschoor (158_CR22) 2010; 137
RC Gentleman (158_CR30) 2004; 5
158_CR36
DJ Weiss (158_CR66) 2008; 69
DJ Weiss (158_CR16) 2005; 66
KE Killick (158_CR57) 2011; 12
TK Rice (158_CR49) 2008; 60
158_CR31
CD Souza (158_CR67) 2007; 68
A Untergasser (158_CR40) 2007; 35
DJ Weiss (158_CR61) 2008; 83
PM Coussens (158_CR1) 2001; 2
DM Kelly (158_CR82) 2008; 76
References_xml – volume: 213
  start-page: 879
  issue: 9–10
  year: 2008
  ident: 158_CR53
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2008.07.009
– volume: 70
  start-page: 5556
  issue: 10
  year: 2002
  ident: 158_CR60
  publication-title: Abrahamsen MS: Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Infect Immun
– volume: 69
  start-page: 804
  issue: 6
  year: 2008
  ident: 158_CR66
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.69.6.804
– volume: 8
  start-page: 668
  issue: 9
  year: 2010
  ident: 158_CR81
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2387
– volume: 156
  start-page: 2119
  issue: 6
  year: 1996
  ident: 158_CR75
  publication-title: J Immunol
  doi: 10.4049/jimmunol.156.6.2119
– volume-title: Diagnosis and Control of Johne's Disease
  year: 2003
  ident: 158_CR3
– volume: 137
  start-page: 1
  issue: 1–2
  year: 2010
  ident: 158_CR22
  publication-title: Karrow NA: Gene expression profiling of PBMCs from Holstein and Jersey cows sub-clinically infected with Mycobacterium avium ssp. paratuberculosis. Vet Immunol Immunopathol
– volume: 91
  start-page: 390
  issue: 5
  year: 2011
  ident: 158_CR56
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2011.07.002
– volume: 22
  start-page: 63
  issue: 2
  year: 2011
  ident: 158_CR85
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2011.02.001
– volume: 72
  start-page: 1409
  issue: 3
  year: 2004
  ident: 158_CR17
  publication-title: McNulty AM: Cytokine gene expression in peripheral blood mononuclear cells and tissues of cattle infected with Mycobacterium avium subsp. paratuberculosis: evidence for an inherent proinflammatory gene expression pattern. Infect Immun
– volume: 70
  start-page: 4961
  issue: 9
  year: 2002
  ident: 158_CR72
  publication-title: Infect Immun
  doi: 10.1128/IAI.70.9.4961-4967.2002
– volume: 194
  start-page: 1423
  issue: 10
  year: 1989
  ident: 158_CR12
  publication-title: J Am Vet Med Assoc
  doi: 10.2460/javma.1989.194.10.1423
– volume: 71
  start-page: 6487
  issue: 11
  year: 2003
  ident: 158_CR54
  publication-title: Elftman MD: Evidence for a novel gene expression program in peripheral blood mononuclear cells from Mycobacterium avium subsp. paratuberculosis-infected cattle. Infect Immun
– volume: 81
  start-page: 283
  issue: 1
  year: 1998
  ident: 158_CR9
  publication-title: J Dairy Sci
  doi: 10.3168/jds.S0022-0302(98)75577-8
– volume: 60
  start-page: 293
  year: 2008
  ident: 158_CR49
  publication-title: Adv Genet
  doi: 10.1016/S0065-2660(07)00412-9
– volume: 2011
  start-page: 405310
  year: 2011
  ident: 158_CR64
  publication-title: Clin Dev Immunol
  doi: 10.1155/2011/405310
– volume: 64
  start-page: 2771
  issue: 21
  year: 2007
  ident: 158_CR70
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-007-7012-3
– volume: 29
  start-page: 365
  issue: 4
  year: 2001
  ident: 158_CR38
  publication-title: Nat Genet
  doi: 10.1038/ng1201-365
– volume: 30
  start-page: 943
  issue: 10
  year: 2008
  ident: 158_CR59
  publication-title: Bioessays
  doi: 10.1002/bies.20815
– volume: 4
  start-page: 279
  issue: 3
  year: 2011
  ident: 158_CR78
  publication-title: Mucosal Immunol
  doi: 10.1038/mi.2011.3
– volume: 10
  start-page: 598
  issue: 6
  year: 2008
  ident: 158_CR62
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2008.02.005
– volume: 240
  start-page: 92
  issue: 1
  year: 2011
  ident: 158_CR91
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2010.00995.x
– ident: 158_CR29
– volume: 68
  start-page: 625
  issue: 6
  year: 2007
  ident: 158_CR67
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.68.6.625
– volume: 23
  start-page: 2897
  issue: 21
  year: 2007
  ident: 158_CR34
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btm478
– volume: 15
  start-page: 255
  issue: 3
  year: 2003
  ident: 158_CR76
  publication-title: Cell Signal
  doi: 10.1016/S0898-6568(02)00075-X
– volume: 76
  start-page: 351
  issue: 1
  year: 2008
  ident: 158_CR82
  publication-title: Infect Immun
  doi: 10.1128/IAI.00614-07
– volume: 88
  start-page: 1
  issue: 1
  year: 2009
  ident: 158_CR6
  publication-title: Prev Vet Med
  doi: 10.1016/j.prevetmed.2008.07.003
– volume: 106
  start-page: 2770
  issue: 8
  year: 2009
  ident: 158_CR87
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0807694106
– volume: 81
  start-page: 283
  issue: 1
  year: 1998
  ident: 158_CR7
  publication-title: J Dairy Sci
  doi: 10.3168/jds.S0022-0302(98)75577-8
– volume: 40
  start-page: D13
  issue: Database issue
  year: 2012
  ident: 158_CR44
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkr1184
– volume: 9
  start-page: 1039
  issue: 8
  year: 2003
  ident: 158_CR80
  publication-title: Nat Med
  doi: 10.1038/nm906
– volume: 65
  start-page: 298
  issue: 1
  year: 1997
  ident: 158_CR79
  publication-title: Infect Immun
  doi: 10.1128/iai.65.1.298-304.1997
– volume: 85
  start-page: 1
  issue: 1
  year: 2011
  ident: 158_CR4
  publication-title: How accurately can we detect Mycobacterium avium subsp. paratuberculosis infection? J Microbiol Methods
– volume: 28
  start-page: 67
  issue: 1
  year: 2006
  ident: 158_CR24
  publication-title: Physiol Genomics
  doi: 10.1152/physiolgenomics.00098.2006
– volume: 140
  start-page: 130
  issue: 1–2
  year: 2011
  ident: 158_CR27
  publication-title: Vet Immunol Immunopathol
  doi: 10.1016/j.vetimm.2010.12.002
– volume: 40
  start-page: 179
  issue: 3–4
  year: 1999
  ident: 158_CR8
  publication-title: Prev Vet Med
  doi: 10.1016/S0167-5877(99)00037-9
– volume: 411
  start-page: 352
  year: 2006
  ident: 158_CR39
  publication-title: Methods Enzymol
  doi: 10.1016/S0076-6879(06)11019-8
– volume: 27
  start-page: 1110
  issue: 7
  year: 2008
  ident: 158_CR88
  publication-title: The EMBO journal
  doi: 10.1038/emboj.2008.31
– volume: 129
  start-page: 217
  issue: 3–4
  year: 2008
  ident: 158_CR5
  publication-title: Vet Microbiol
  doi: 10.1016/j.vetmic.2007.12.011
– volume: 56
  start-page: 1322
  issue: 10
  year: 1995
  ident: 158_CR11
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.1995.56.10.1322
– ident: 158_CR31
– volume: 119
  start-page: 753
  issue: 6
  year: 2004
  ident: 158_CR89
  publication-title: Cell
  doi: 10.1016/j.cell.2004.11.038
– volume: 83
  start-page: 48
  issue: 1
  year: 2008
  ident: 158_CR61
  publication-title: Bovine monocyte TLR2 receptors differentially regulate the intracellular fate of Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. J Leukoc Biol
– volume: 2010
  start-page: baq020
  issue: Database issue
  year: 2010
  ident: 158_CR45
  publication-title: Database (Oxford)
– volume: 66
  start-page: 721
  issue: 4
  year: 2005
  ident: 158_CR16
  publication-title: Am J Vet Res
  doi: 10.2460/ajvr.2005.66.721
– volume: 87
  start-page: 429
  issue: 3–4
  year: 2002
  ident: 158_CR21
  publication-title: Coussens PM: Survival tactics of M. paratuberculosis in bovine macrophage cells. Vet Immunol Immunopathol
– volume: 3
  start-page: Article3
  year: 2004
  ident: 158_CR35
  publication-title: Stat Appl Genet Mol Biol
  doi: 10.2202/1544-6115.1027
– volume: 45
  start-page: 829
  issue: 6
  year: 2008
  ident: 158_CR15
  publication-title: Modulation of mononuclear phagocyte function by Mycobacterium avium subsp. paratuberculosis. Vet Pathol
– volume: 11
  start-page: 373
  issue: 5
  year: 2010
  ident: 158_CR68
  publication-title: Nat Immunol
  doi: 10.1038/ni.1863
– volume: 44
  start-page: 215
  issue: 3
  year: 2008
  ident: 158_CR20
  publication-title: Weiss DJ: Role of cell membrane receptors in the suppression of monocyte anti-microbial activity against Mycobacterium avium subsp. paratuberculosis. Microb Pathog
– volume: 25
  start-page: 131
  issue: 2
  year: 1988
  ident: 158_CR14
  publication-title: Vet Pathol
  doi: 10.1177/030098588802500205
– volume: 7
  start-page: 767
  issue: 10
  year: 2007
  ident: 158_CR90
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2161
– volume: 57
  start-page: 289
  issue: 1
  year: 1995
  ident: 158_CR37
  publication-title: J R Stat Soc Series B Stat Methodol
  doi: 10.1111/j.2517-6161.1995.tb02031.x
– volume: 2
  start-page: 20
  issue: 1
  year: 2005
  ident: 158_CR71
  publication-title: Cell Mol Immunol
– volume: 22
  start-page: 943
  issue: 8
  year: 2006
  ident: 158_CR33
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btl033
– volume: 39
  start-page: 461
  issue: 4
  year: 1993
  ident: 158_CR26
  publication-title: Vet Immunol Immunopathol
  doi: 10.1016/0165-2427(93)90075-F
– volume: 47
  start-page: 1089
  issue: 11
  year: 2006
  ident: 158_CR18
  publication-title: Can Vet J
– volume: 70
  start-page: 5494
  issue: 10
  year: 2002
  ident: 158_CR25
  publication-title: Infect Immun
  doi: 10.1128/IAI.70.10.5494-5502.2002
– volume: 8
  start-page: R19
  issue: 2
  year: 2007
  ident: 158_CR41
  publication-title: Genome Biol
  doi: 10.1186/gb-2007-8-2-r19
– volume: 582
  start-page: 445
  issue: 3
  year: 2008
  ident: 158_CR77
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2008.01.007
– volume: 35
  start-page: W71
  issue: Web Server issu
  year: 2007
  ident: 158_CR40
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkm306
– volume: 167
  start-page: 3339
  issue: 6
  year: 2001
  ident: 158_CR74
  publication-title: J Immunol
  doi: 10.4049/jimmunol.167.6.3339
– volume: 37
  start-page: 141
  issue: 2
  year: 2011
  ident: 158_CR2
  publication-title: Ricke SC:. Current perspectives on Mycobacterium avium subsp. paratuberculosis, Johne's disease, and Crohn's disease: a review. Crit Rev Microbiol
– volume: 573
  start-page: 223
  year: 2009
  ident: 158_CR48
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-60761-247-6_13
– ident: 158_CR36
– volume: 2
  start-page: 141
  issue: 2
  year: 2001
  ident: 158_CR1
  publication-title: Anim Health Res Rev
  doi: 10.1079/AHRR200134
– volume: 111
  start-page: 323
  issue: 3
  year: 2004
  ident: 158_CR95
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2004.01812.x
– volume: 240
  start-page: 252
  issue: 1
  year: 2011
  ident: 158_CR84
  publication-title: Immunol Rev
  doi: 10.1111/j.1600-065X.2010.00984.x
– volume: 8
  start-page: 175
  year: 2006
  ident: 158_CR46
  publication-title: Biol Proced Online
  doi: 10.1251/bpo126
– volume: 128
  start-page: 44
  issue: 1–3
  year: 2009
  ident: 158_CR94
  publication-title: Vet Immunol Immunopathol
  doi: 10.1016/j.vetimm.2008.10.294
– volume: 12
  start-page: 611
  year: 2011
  ident: 158_CR57
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-12-611
– volume: 9
  start-page: 220
  issue: 3
  year: 2010
  ident: 158_CR23
  publication-title: Brief Funct Genomics
  doi: 10.1093/bfgp/elq009
– volume: 67
  start-page: 2
  issue: 1
  year: 2000
  ident: 158_CR93
  publication-title: J Leukoc Biol
  doi: 10.1002/jlb.67.1.2
– volume: 3
  start-page: e1403
  issue: 1
  year: 2008
  ident: 158_CR52
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0001403
– volume: 40
  start-page: 491
  issue: 4
  year: 2009
  ident: 158_CR51
  publication-title: Am J Respir Cell Mol Biol
  doi: 10.1165/rcmb.2008-0219OC
– volume: 2
  start-page: 189
  issue: 3
  year: 2004
  ident: 158_CR58
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro840
– volume: 18
  start-page: 393
  issue: 3
  year: 2011
  ident: 158_CR28
  publication-title: Early immune markers associated with Mycobacterium avium subsp. paratuberculosis infection in a neonatal calf model. Clin Vaccine Immunol
– volume: 34
  start-page: 680
  issue: 5
  year: 2011
  ident: 158_CR86
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.05.003
– volume: 183
  start-page: 2293
  issue: 5
  year: 1996
  ident: 158_CR43
  publication-title: J Exp Med
  doi: 10.1084/jem.183.5.2293
– volume: 8
  start-page: 400
  year: 2007
  ident: 158_CR55
  publication-title: BMC Genomics
  doi: 10.1186/1471-2164-8-400
– volume: 144
  start-page: 281
  issue: 2
  year: 2006
  ident: 158_CR83
  publication-title: Clin Exp Immunol
  doi: 10.1111/j.1365-2249.2006.03053.x
– volume: 47
  start-page: 874
  issue: 9
  year: 2006
  ident: 158_CR19
  publication-title: Can Vet J
– volume: 35
  start-page: 580
  issue: 5
  year: 2011
  ident: 158_CR50
  publication-title: Dev Comp Immunol
  doi: 10.1016/j.dci.2011.01.001
– volume: 5
  start-page: e1000665
  issue: 11
  year: 2009
  ident: 158_CR92
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000665
– volume: 72
  start-page: 3089
  issue: 6
  year: 2004
  ident: 158_CR13
  publication-title: Infect Immun
  doi: 10.1128/IAI.72.6.3089-3096.2004
– volume: 8
  start-page: 296
  issue: 4
  year: 2010
  ident: 158_CR63
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2321
– volume: 21
  start-page: 3683
  issue: 18
  year: 2005
  ident: 158_CR32
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/bti605
– volume: 9
  start-page: 1545
  issue: 14–15
  year: 2007
  ident: 158_CR73
  publication-title: Weiss DJ: Role of the mitogen-activated protein kinase pathway in the differential response of bovine monocytes to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium. Microbes Infect
– volume: 5
  start-page: e1000234
  issue: 3
  year: 2009
  ident: 158_CR10
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1000234
– volume: 5
  start-page: R80
  issue: 10
  year: 2004
  ident: 158_CR30
  publication-title: Genome Biol
  doi: 10.1186/gb-2004-5-10-r80
– volume: 700
  start-page: 17
  year: 2011
  ident: 158_CR47
  publication-title: Methods Mol Biol
  doi: 10.1007/978-1-61737-954-3_2
– volume: 300
  start-page: 1524
  issue: 5625
  year: 2003
  ident: 158_CR69
  publication-title: Science
  doi: 10.1126/science.1085536
– volume: 183
  start-page: 2293
  issue: 5
  year: 1996
  ident: 158_CR42
  publication-title: J Exp Med
  doi: 10.1084/jem.183.5.2293
– volume: 2
  start-page: 2
  year: 2011
  ident: 158_CR65
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2011.00002
SSID ssj0016354
Score 2.2298675
Snippet Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences....
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic consequences....
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne's disease, an intestinal disease of ruminants with major economic consequences....
Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne?s disease, an intestinal disease of ruminants with major economic consequences....
Abstract Mycobacterium avium subspecies paratuberculosis is the causative agent of Johne’s disease, an intestinal disease of ruminants with major economic...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 25
SubjectTerms Animals
apoptosis
Cattle
digestive system diseases
Female
females
gene expression
Gene Expression Profiling - veterinary
Gene Expression Regulation
Genes
Genetic aspects
Health aspects
Host-Pathogen Interactions
host-pathogen relationships
hosts
Immunology
immunopathology
Johne's disease
Macrophages
Macrophages - immunology
Macrophages - microbiology
Medicine
Medicine & Public Health
Microbiology
Mycobacterium avium
Mycobacterium avium subsp. paratuberculosis - physiology
Oligonucleotide Array Sequence Analysis - veterinary
paratuberculosis
Paratuberculosis - genetics
Paratuberculosis - immunology
Paratuberculosis - microbiology
Physiological aspects
Polymerase Chain Reaction - veterinary
Risk factors
systems analysis
Time Factors
transcription (genetics)
transcriptome
transcriptomics
Veterinary Medicine/Veterinary Science
Virology
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQxYELgvIKFGQkJOAQmnW8dnIsiIoDrXqAqjfLr6iRugnKY0V_Dv-UGce72hQVLlyiZG2vbM-X8Yw9-YaQN9JamWXepiBvm3KkIdQ6h0telcZWeSSrPv8qT0-Li4vybCfVF8aETfTA08QdWvCgpNeld4Zz6VjpqlIYDzDlTiy8Qe0LVs_GmYrnB7CMBuKoEveOwMOIpD6LQhzCAidTJE6CnqWYIXtnPQq0_X8q553V6Wbk5I3j07AqHT8g96M5SY-mYTwkd3yzT_bPMcYlfGhLT-LZ-SPy60w3KVKyrmpLdeQioW1FDW4qeAp4bO314FMHbdfe0ZXG9F6XoHAoNPPU_4xBsw2tG9pNwbWeDi0-ruuhw5sptKuhuL9LT64tqItABz2uqF7jtQdNhTnvfU8D7fhofGfHqxY685h8P_787dOXNCZoSC3YSUNqM6ezSjLjnOSc-0x68D6cqzhzRSXBmCukZoYLo8EsEoXFU0dv0eYwWmqRPyF7Tdv4Z4QK1HZCa-OWglcgo-XCaV0uGMu4FHyZkA8bMSkb2csxicaVCl5MIRTKVaFcFc8Vgwbvtg1-TMQdt1f9iHLfVkPG7fAD4FBFHKp_4TAhbxE1CvUCdMzq-HkDDA8ZttQRKwswhoXIEnIwqwnvs50Vv97gTmERBsE1vh17hdyHAhOasr_UAfeeSTBbi4Q8nbC6HRdYa0tQuTIhcobi2cDnJU19GSjHwdaBf4aZer_Bu4q6rr9tVp__j1l9Qe4BWhgG_bHigOwN3ehfkrt2PdR99yq8878BP0JciQ
  priority: 102
  providerName: Directory of Open Access Journals
Title Pan-genomic analysis of bovine monocyte-derived macrophage gene expression in response to in vitro infection with Mycobacterium avium subspecies paratuberculosis
URI https://link.springer.com/article/10.1186/1297-9716-43-25
https://www.ncbi.nlm.nih.gov/pubmed/22455317
https://www.proquest.com/docview/1032610552
https://www.proquest.com/docview/1446276128
https://pubmed.ncbi.nlm.nih.gov/PMC3411445
https://doaj.org/article/c8377ea9edb447d29df96be3054d61eb
Volume 43
WOSCitedRecordID wos000307291600001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVADU
  databaseName: Open Access: BioMedCentral Open Access Titles
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: RBZ
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.biomedcentral.com/search/
  providerName: BioMedCentral
– providerCode: PRVAON
  databaseName: Directory of Open Access Journals (DOAJ)
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: DOA
  dateStart: 20110101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVAVX
  databaseName: SpringerLINK Contemporary 1997-Present
  customDbUrl:
  eissn: 1297-9716
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0016354
  issn: 1297-9716
  databaseCode: RSV
  dateStart: 20111201
  isFulltext: true
  titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22
  providerName: Springer Nature
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLa2gRAvXMqtMCojIQEPGanr2s7jhph4YNM0oKp4sXwLq7QmU5pW7OfwTznHTSoyGBK8RG1sR76c851j-_gzIS-lczJNg0tgvF3CkYbQmBE8RnlmXT5qyKonH-XxsZpOs5MtMmzPwsRo93ZLMiJ1VGsl3oJhkgkSHsEXEzbeJjfA1inUxdNPk83GAdhP3jD4_KFQx_hEjv7fkfgXU3Q1TPLKXmk0QYd3_6Py98idxt-k-2sBuU-2QtEjt46aHfUe6U0wHiYeyqXt2wfkx4kpEqRvnc8cNQ1vCS1zanEBIlCQ3dJd1iHxUHYVPJ0bvArsDMCJQrFAw_cmwLags4JW60DcQOsS_65mdYU_1mFgBcW1YHp06QBaInX0ck7NCp8LQLWLAOizoJGifGlD5ZbnJVTmIfly-P7zuw9Jc5lD4sCnqhOXepPmklnvJec8pDLATMX7nDOvcgmOn5KGWS6sARdKKIc7lMGhf2KNNGL0iOwUZRGeECoQGYUx1o8Fz6Frx0NvTDZkLOVS8HGf7LWjrF3DdI4XbpzrOONRQuNwaBwOzUeaQYHXmwIXa5KP67MeoNhssiE7d3xRVt90o-zawaxfBpMFbzmXnmU-z4QNAK3ci2GwffIKhU4jhkDFnGmOQkDzkI1L77NMgeMsRNonu52coPuuk_yiFVuNSRgwV4RyudDIkyjw8lP2lzycCybBxVV98ngt6pt2gWc3BniWfSI7StBpeDelmJ1FenLwi-DL0FNvWlXQDS4uruvVp_-Q9xm5DULBMA6QqV2yU1fL8JzcdKt6tqgGZFtO1SCurMDz9ODrIOLDTzh7YaI
linkProvider Springer Nature
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbGQMALl3IrDDASEuwhkLqOnTwOxDREW00wqr1ZvoVVWpMpTSv2c_innOMmFRkMCV6iJD6OfDn-znF8_JmQl9JaGcfeRtDfNuJIQ6j1EC7DPDM2HzZk1dORnEzS4-PscIsM2r0wIdq9XZIMSB2GdSregmGSERIewRcjllwhVzmYK4zi-_xlulk4APvJGwafP2TqGJ_A0f87Ev9iii6GSV5YKw0maP_2fxT-DrnV-Jt0b60gd8mWL3rk-rhZUe-R3hTjYcKmXNq-vUd-HOoiQvrW-cxS3fCW0DKnBn9AeAq6W9rz2kcO8q68o3ONR4GdADhRyOap_94E2BZ0VtBqHYjraV3i42pWV3izDgMrKP4LpuNzC9ASqKOXc6pXeF0Aqp15QJ8FDRTlS-MruzwtoTD3ydf9D0fvD6LmMIfIgk9VRzZ2Os4lM85JzrmPpYeZinM5Zy7NJTh-qdTMcGE0uFAitbhC6S36J0ZLLYYPyHZRFv4RoQKRUWhtXCJ4Dk2bDJzW2YCxmEvBkz550_aysg3TOR64carCjCcVCrtDYXcoPlQMMrzeZDhbk3xcLvoO1WYjhuzc4UVZfVPNYFcWZv3S68w7w7l0LHN5JowHaOVODLzpk1eodAoxBApmdbMVAqqHbFxqj2UpOM5CxH2y05GEsW87yS9atVWYhAFzhS-XC4U8iQIPP2V_keFcMAkubtonD9eqvqkXeHYJwLPsE9kZBJ2Kd1OK2UmgJwe_CL4MLbXbDgXV4OLislZ9_A-yz8mNg6PxSI0-Tj49ITdBQRjGBLJ0h2zX1dI_Jdfsqp4tqmcBGX4C6dlhmg
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdgoIkXPspXYYCRkICHbKnj2snj-KhAbFUloNqb5dgOq7QmVZJW7M_hP-UucSoyGBLiJWrjuyi2z787x-efCXkhjZFh6EwA_W0CjjSEWkdwibIkNVnkyarnR3I6jU9OkpnPzam6bPduSbLd04AsTXl9sLJZO8RjcQBOSgZIfgRPD9j4KrnG8cQgnKx_nm8XEcCXcs_m8welniNq-Pp_R-Vf3NLFlMkL66aNO5rc-s-K3CY3fRxKD1vDuUOuuHxAdo_9SvuADOaYJ9Ns1qXd3bvkx0znAdK6LheGas9nQouMpvhhwlGw6cKc1y6woLtxli41HhF2CqBFQc1R990n3uZ0kdOyTdB1tC7w72ZRl_ijTQ_LKX4jpsfnBiCnoZReL6ne4LUCtFs5QKWKNtTl69SVZn1WwMvcI18n77-8_RD4Qx4CA7FWHZjQ6jCTLLVWcs5dKB3MYKzNOLNxJiEgjKVmKRephtBKxAZXLp3BuCXVUovoPtnJi9w9JFQgYgqtUzsWPIOmHY-s1smIsZBLwcdDst_1uDKeAR0P4jhTzUwoFgq7Q2F3KB4pBgqvtgqrlvzjctE3aEJbMWTtbm4U5TflQUCZOJLS6cTZlHNpWWKzRKQOIJdbMXLpkLxEA1SILfBiRvstElA9ZOlShyyJIaAWIhySvZ4kYILpFT_vTFhhESbS5a5YVwr5EwUeisr-IsO5YBJC33hIHrRmv60XRHxjgG05JLI3IHoV75fki9OGthziJXgytNTrblgoj5fVZa366B9kn5Hd2buJOvo4_fSY3AD7YJgqyOI9slOXa_eEXDebelGVTxuQ-AkctGp-
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Pan-genomic+analysis+of+bovine+monocyte-derived+macrophage+gene+expression+in+response+to+in+vitro+infection+with+Mycobacterium+avium+subspecies+paratuberculosis&rft.jtitle=Veterinary+research+%28Paris%29&rft.au=Machugh%2C+David+E&rft.au=Taraktsoglou%2C+Maria&rft.au=Killick%2C+Kate+E&rft.au=Nalpas%2C+Nicolas+C&rft.date=2012-03-28&rft.issn=1297-9716&rft.eissn=1297-9716&rft.volume=43&rft.spage=25&rft_id=info:doi/10.1186%2F1297-9716-43-25&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1297-9716&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1297-9716&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1297-9716&client=summon