Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease

Both the misfolding of α-synuclein and mitochondrial dysfunction are considered two major contributors to Parkinson's disease (PD). However, the relationship between the two in normal and PD states remains unclear. Here, we report that voltage-dependent anion channel 1 (VDAC1), a major componen...

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Vydáno v:	Neurobiology of disease Ročník 69; s. 1 - 14
Hlavní autoři:	Chu, Yaping, Goldman, Jennifer G., Kelly, Leo, He, Yinzhen, Waliczek, Tracy, Kordower, Jeffrey H.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.09.2014 Elsevier
Témata:	Aged Aged, 80 and over alpha-Synuclein - genetics alpha-Synuclein - metabolism Animals Brain - metabolism Brain - pathology Corpus Striatum - metabolism Corpus Striatum - pathology Down-Regulation Female Humans Male Middle Aged Mitochondria Mutation Neurology Neurons - metabolism Neurons - pathology Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Parkinsonian Disorders - metabolism Parkinsonian Disorders - pathology Rats, Sprague-Dawley Striatum Substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology Voltage-Dependent Anion Channel 1 - metabolism α-Synuclein α-Synuclein Striatum Mitochondria Parkinson's disease Substantia nigra
ISSN:	0969-9961, 1095-953X, 1095-953X
On-line přístup:	Získat plný text
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