Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells

The potential of the skin immune system to generate immune responses is well established, and the skin is actively exploited as a vaccination site. Human skin contains several antigen-presenting cell subsets with specialized functions. In particular, the capacity to cross-present exogenous antigens...

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Bibliographic Details
Published in:	Cellular & molecular immunology Vol. 14; no. 4; pp. 360 - 370
Main Authors:	Fehres, Cynthia M, Duinkerken, Sanne, Bruijns, Sven CM, Kalay, Hakan, van Vliet, Sandra J, Ambrosini, Martino, de Gruijl, Tanja D, Unger, Wendy WJ, Garcia-Vallejo, Juan J, van Kooyk, Yvette
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.04.2017 Nature Publishing Group
Subjects:	Antibodies Antibodies - metabolism Antigen presentation Antigen-presenting cells Antigens Antigens - metabolism Antigens, CD - metabolism Antiviral agents Biomedical and Life Sciences Biomedicine CD8 antigen Cell Compartmentation Cell Differentiation - drug effects Cross-Priming - drug effects Cross-Priming - immunology Cytotoxicity Endocytosis - drug effects Endosomes Endosomes - drug effects Endosomes - metabolism Humans Immunology Immunotherapy Internalization Langerhans cells Langerhans Cells - cytology Langerhans Cells - drug effects Langerhans Cells - metabolism Lectins, C-Type - metabolism Ligands Lymphocytes T Mannose-Binding Lectins - metabolism Medical Microbiology Microbiology Peptides Peptides - metabolism Poly I-C - pharmacology Proteolysis research-article Skin Skin - metabolism TLR3 protein Toll-like receptors Toll-Like Receptors - metabolism Toll样受体 Tumors Vaccination Vaccine 人类介导修饰内化抗原呈递早期细胞亚群 early endosomes langerin human Langerhans cells dectin-1 antigen cross-presentation
ISSN:	1672-7681, 2042-0226, 2042-0226
Online Access:	Get full text
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