Long non-coding RNA expression profiles predict clinical phenotypes in glioma

Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-relat...

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Published in:	Neurobiology of disease Vol. 48; no. 1; pp. 1 - 8
Main Authors:	Zhang, Xiaoqin, Sun, Stella, Pu, Jenny Kan Suen, Tsang, Anderson Chun On, Lee, Derek, Man, Venus On Ying, Lui, Wai Man, Wong, Stanley Thian Sze, Leung, Gilberto Ka Kit
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.10.2012 Elsevier
Subjects:	Adult Astrocytoma Astrocytoma - genetics Astrocytoma - pathology Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Classification Data processing Differentiation Gene expression Gene Expression Profiling Glioma Humans LncRNA profiling Malignancy Nervous system Neurology non-coding RNA Oligodendroglioma Oligodendroglioma - genetics Oligodendroglioma - pathology Phenotype RNA, Long Noncoding - genetics Malignancy Glioma Astrocytoma LncRNA profiling Oligodendroglioma
ISSN:	0969-9961, 1095-953X, 1095-953X
Online Access:	Get full text
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Abstract	Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies. ► LncRNAs represented on Affymetrix HG-U133 Plus 2.0 array were identified. ► LncRNAs were aberrantly expressed in human glioma. ► Differential expressions of lncRNAs may correlate with malignant progression and histological differentiation in glioma.
AbstractList	Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies. Abstract Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies. Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies.Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies. Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcripts that have been shown to play important roles in cancer development. To discover novel tumor-related lncRNAs and determine their associations with glioma subtypes, we first applied a lncRNA classification pipeline to identify 1970 lncRNAs that were represented on Affymetrix HG-U133 Plus 2.0 array. We then analyzed the lncRNA expression patterns in a set of previously published glioma gene expression profiles of 268 clinical specimens, and identified sets of lncRNAs that were unique to different histological subtypes (astrocytic versus oligodendroglial tumors) and malignancy grades. These lncRNAs signatures were then subject to validation in another non-overlapping, independent data set that contained 157 glioma samples. This is the first reported study that correlates lncRNA expression profiles with malignancy grade and histological differentiation in human gliomas. Our findings indicate the potential roles of lncRNAs in the biogenesis, development and differentiation of gliomas, and provide an important platform for future studies. ► LncRNAs represented on Affymetrix HG-U133 Plus 2.0 array were identified. ► LncRNAs were aberrantly expressed in human glioma. ► Differential expressions of lncRNAs may correlate with malignant progression and histological differentiation in glioma.
Author	Sun, Stella Lui, Wai Man Leung, Gilberto Ka Kit Man, Venus On Ying Pu, Jenny Kan Suen Lee, Derek Tsang, Anderson Chun On Zhang, Xiaoqin Wong, Stanley Thian Sze
Author_xml	– sequence: 1 givenname: Xiaoqin surname: Zhang fullname: Zhang, Xiaoqin organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 2 givenname: Stella surname: Sun fullname: Sun, Stella organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 3 givenname: Jenny Kan Suen surname: Pu fullname: Pu, Jenny Kan Suen organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 4 givenname: Anderson Chun On surname: Tsang fullname: Tsang, Anderson Chun On organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 5 givenname: Derek surname: Lee fullname: Lee, Derek organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 6 givenname: Venus On Ying surname: Man fullname: Man, Venus On Ying organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 7 givenname: Wai Man surname: Lui fullname: Lui, Wai Man organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 8 givenname: Stanley Thian Sze surname: Wong fullname: Wong, Stanley Thian Sze organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong – sequence: 9 givenname: Gilberto Ka Kit surname: Leung fullname: Leung, Gilberto Ka Kit email: gilberto@hkucc.hku.hk organization: Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22709987$$D View this record in MEDLINE/PubMed
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Keywords	Malignancy Glioma Astrocytoma LncRNA profiling Oligodendroglioma
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Snippet	Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs) are a... Abstract Glioma is the commonest form of primary brain tumor in adults with varying malignancy grades and histological subtypes. Long non-coding RNAs (lncRNAs)...
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SubjectTerms	Adult Astrocytoma Astrocytoma - genetics Astrocytoma - pathology Brain Neoplasms - genetics Brain Neoplasms - pathology Brain tumors Classification Data processing Differentiation Gene expression Gene Expression Profiling Glioma Humans LncRNA profiling Malignancy Nervous system Neurology non-coding RNA Oligodendroglioma Oligodendroglioma - genetics Oligodendroglioma - pathology Phenotype RNA, Long Noncoding - genetics
Title	Long non-coding RNA expression profiles predict clinical phenotypes in glioma
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