Network study of nasal transcriptome profiles reveals master regulator genes of asthma

Nasal transcriptomics can provide an accessible window into asthma pathobiology. Our goal was to move beyond gene signatures of asthma to identify master regulator genes that causally regulate genes associated with asthma phenotypes. We recruited 156 children with severe persistent asthma and contro...

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Vydáno v:	Journal of allergy and clinical immunology Ročník 147; číslo 3; s. 879 - 893
Hlavní autoři:	Do, Anh N., Chun, Yoojin, Grishina, Galina, Grishin, Alexander, Rogers, Angela J., Raby, Benjamin A., Weiss, Scott T., Vicencio, Alfin, Schadt, Eric E., Bunyavanich, Supinda
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.03.2021 Elsevier Limited
Témata:	Adolescent Age Asthma Asthma - genetics Child Children Cohort Studies Comparative analysis Digital Object Identifier Disease Family medical history Female Forkhead Transcription Factors - genetics Formins - genetics Gene expression Gene Expression Profiling Humans Inflammation Intracellular Signaling Peptides and Proteins - genetics Male master regulator mild persistent asthma Models, Statistical moderate persistent asthma nasal network Nose - physiology Phenotype Phenotypes probabilistic causal network Quality control severe persistent asthma Spirometry Transcriptome Transcriptomes New York log2 FC transcriptome GO KDA WGCNA Asthma network ATOM nasal master regulator moderate persistent asthma RNA-seq FDR mild persistent asthma ARIA probabilistic causal network severe persistent asthma gene expression
ISSN:	0091-6749, 1097-6825, 1097-6825
On-line přístup:	Získat plný text
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