Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment

Rationale Identification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services. Objectives Given that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency h...

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Bibliographic Details
Published in:Psychopharmacologia Vol. 222; no. 1; pp. 17 - 26
Main Authors: Garland, Eric L., Franken, Ingmar H. A., Howard, Matthew O.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01.07.2012
Springer
Springer Nature B.V
Subjects:
Addiction
Addictive behaviors
Adult
Adult and adolescent clinical studies
Alcoholics
Alcoholism
Alcoholism - rehabilitation
Alcoholism and acute alcohol poisoning
Antibodies
Attention
Bias
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Care and treatment
Cognition
Cognitive Behavioral Therapy - methods
Cues
Diseases
Drug dependence
Ethanol
Female
Follow-Up Studies
Heart beat
Heart rate
Heart Rate - physiology
Humans
Male
Medical sciences
Neurosciences
Original Investigation
Pharmacology/Toxicology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Recurrence
Relapse
Self-Help Groups
Severity of Illness Index
Substance abuse
Substance abuse treatment
Toxicology
Treatment Outcome
Alcohol dependence
Attentional bias
Relapse
Cue-reactivity
Heart rate variability
Alcoholism
Attention
Heart rate
Alcoholic beverage
Treatment
Dependence
Predictive factor
Cognitive bias
ISSN:0033-3158, 1432-2072, 1432-2072
Online Access:Get full text
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Summary:Rationale Identification of malleable neurocognitive predictors of relapse among alcohol-dependent individuals is important for the optimization of health care delivery and clinical services. Objectives Given that alcohol cue-reactivity can predict relapse, we evaluated cue-elicited high-frequency heart rate variability (HFHRV) and alcohol attentional bias (AB) as potential relapse risk indices. Method Alcohol-dependent patients in long-term residential treatment who had participated in mindfulness-oriented therapy or an addiction support group completed a spatial cueing task as a measure of alcohol AB and an affect-modulated alcohol cue-reactivity protocol while HFHRV was assessed. Results Post-treatment HFHRV cue-reactivity and alcohol AB significantly predicted the occurrence and timing of relapse by 6-month follow-up, independent of treatment condition and after controlling for alcohol dependence severity. Alcohol-dependent patients who relapsed exhibited a significantly greater HFHRV reactivity to stress-primed alcohol cues than patients who did not relapse. Conclusions Cue-elicited HFHRV and alcohol AB can presage relapse and may therefore hold promise as prognostic indicators in clinical settings.
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ISSN:0033-3158
1432-2072
1432-2072
DOI:10.1007/s00213-011-2618-4