Development of an RT-RPA assay for La Crosse virus detection provides insights into age-dependent neuroinvasion in mice

Background La Crosse virus (LACV) is a mosquito-borne arbovirus responsible for pediatric encephalitis in North America, predominantly affecting children under 16 years. Early and accurate diagnosis is critical to reducing morbidity in this vulnerable population. However, existing molecular and sero...

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Bibliographic Details
Published in:	Virology journal Vol. 22; no. 1; p. 95
Main Authors:	Lumkong, Lily, Alatrash, Reem, Sridhar, Sainetra, Tonto, Prince Baffour, Herrera, Bobby Brooke
Format:	Journal Article
Language:	English
Published:	London BioMed Central 09.04.2025 BioMed Central Ltd BMC
Subjects:	adults Age Factors Age factors in disease Age-susceptible mouse model Analysis animal models Animals Arbovirus diseases arboviruses at-risk population Biochemical assays Biomedical and Life Sciences Biomedicine California encephalitis orthobunyavirus Central nervous system diseases Complications and side effects detection limit Diagnosis Disease Models, Animal DNA Primers - genetics Encephalitis Encephalitis, California - diagnosis Encephalitis, California - virology Female Genetic transcription genome Genomics Health aspects La Crosse virus La Crosse virus - genetics La Crosse virus - isolation & purification Lateral flow assay Methods Mice Molecular diagnostic techniques morbidity Neuroinvasion North America Nucleic Acid Amplification Techniques - methods oligodeoxyribonucleotides point-of-care systems recombinase polymerase amplification reverse transcription Reverse transcription recombinase polymerase amplification Risk factors RNA RNA, Viral - genetics Sensitivity and Specificity therapeutics Virology weanlings United States North America Lateral flow assay Neuroinvasion La Crosse virus Reverse transcription recombinase polymerase amplification Age-susceptible mouse model
ISSN:	1743-422X, 1743-422X
Online Access:	Get full text
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