Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma

Multiple molecular features, such as activation of specific oncogenes (e.g., MYC, BCL2) or a variety of gene expression signatures, have been associated with disease course in diffuse large B‐cell lymphoma (DLBCL), although their relationships and implications for targeted therapy remain to be fully...

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Bibliographic Details
Published in:	Molecular oncology Vol. 16; no. 5; pp. 1132 - 1152
Main Authors:	Donati, Giulio, Ravà, Micol, Filipuzzi, Marco, Nicoli, Paola, Cassina, Laura, Verrecchia, Alessandro, Doni, Mirko, Rodighiero, Simona, Parodi, Federica, Boletta, Alessandra, Vellano, Christopher P., Marszalek, Joseph R., Draetta, Giulio F., Amati, Bruno
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01.03.2022 John Wiley and Sons Inc Wiley
Subjects:	Apoptosis B-cell lymphoma BCL2 Chemotherapy DLBCL Drug development Electron transport chain Gene expression Glucose Humans Integrated Stress Response Leukemia Lymphocytes B Lymphoma Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - genetics Malignancy Medical prognosis Mitochondria MYC Myc protein Oncogenes Oxidative phosphorylation OxPhos Patients Phosphorylation Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Respiration Therapeutic targets Transcription factors Transplants & implants United States > US Italy Germany BCL2 DLBCL Integrated Stress Response OxPhos chemotherapy MYC
ISSN:	1574-7891, 1878-0261, 1878-0261
Online Access:	Get full text
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